Journal of Neuro-Oncology • Vol 165 • No 1
Cerebrospinal fluid circulating tumour DNA genotyping and survival analysis in lung adenocarcinoma with leptomeningeal metastases
October 2023 • Kaixuan Bai, Xin Chen, Xuejiao Qi, Yu Zhang, Yueli Zou, Jian Li, Lili Yu, Yuanyuan Li, Jiajia Jiang, Yi Yang, Yajing Liu, Shuanghao Feng, Hui Bu
Abstract Purpose The prognosis of patients with leptomeningeal metastasis (LM) remains poor. Circulating tumour DNA (ctDNA) has been proven to be abundantly present in cerebrospinal fluid (CSF); hence, its clinical implication as a biomarker needs to be further verified. Methods We conducted a retrospective study of 35 lung adenocarcinoma (LUAD) patients with LM, and matched CSF and plasma samples were collected from all patients. All paired samples underwent next-generation sequencing (NGS) of 139 lung cancer-ass…