Cerium Oxide Nanoparticles Achieve Long‐Lasting Senescence Inhibition in an Aging Mouse Model of Sarcopenia via Reactive Oxygen Species Scavenging and CILP2 Downregulation Article Swipe
Wei‐Chih Lien
,
Yu‐Ling Yu
,
Ya‐Jyun Liang
,
Chia‐Yih Wang
,
Yang‐Chen Lin
,
Huei‐Cih Chang
,
Feng‐Huei Lin
,
Huimin Wang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/smsc.202500208
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/smsc.202500208
Most drugs used to treat sarcopenia are ineffective. Herein, the long‐acting anti‐sarcopenic properties of cerium oxide nanoparticles (CeNPs) and their underlying mechanisms of action are investigated in aging mice (treated with 4‐hydroperoxy cyclophosphamide (4‐HC)). CeNPs (size, 27.5 nm) with a fluorite crystallization structure are synthesized and subjected to X‐ray diffraction and gas adsorption analyzes. Synthesized CeNPs exhibit Ce 3+ and Ce 4+ on their surfaces, a specific surface area within the standard range, and self‐regenerative antioxidative functions. Synthesized CeNPs reduce reactive oxygen species (ROS) levels and exhibit good biocompatibility in muscle satellite (C2C12) cells. According to Rotarod, tensile, and histological analyzes, CeNP treatment once per week in 4‐HC‐treated mice markedly increases muscle strength and the cross‐sectional muscle tissue area relative to that in control mice. Next‐generation sequencing identifies CILP2 as a key differentially upregulated gene common to aging muscle tissues and satellite cells in the presence of ROS. Quantitative polymerase chain reaction and western blotting confirm CILP2, Serpine1, phospho‐p21, Atrogin‐1, and Cxcl10 downregulation in CeNP‐treated mice (compared with 4‐HC‐treated mice); in vitro CILP2 knockdown results in Serpine1 and phospho‐p21 downregulation. These findings confirm the long‐acting effects of CeNPs against sarcopenia in older individuals.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/smsc.202500208
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/smsc.202500208
- OA Status
- gold
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411674847
All OpenAlex metadata
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https://openalex.org/W4411674847Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/smsc.202500208Digital Object Identifier
- Title
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Cerium Oxide Nanoparticles Achieve Long‐Lasting Senescence Inhibition in an Aging Mouse Model of Sarcopenia via Reactive Oxygen Species Scavenging and CILP2 DownregulationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-06-26Full publication date if available
- Authors
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Wei‐Chih Lien, Yu‐Ling Yu, Ya‐Jyun Liang, Chia‐Yih Wang, Yang‐Chen Lin, Huei‐Cih Chang, Feng‐Huei Lin, Huimin WangList of authors in order
- Landing page
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https://doi.org/10.1002/smsc.202500208Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/smsc.202500208Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/smsc.202500208Direct OA link when available
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Reactive oxygen species, Downregulation and upregulation, Sarcopenia, Chemistry, Cell biology, Biochemistry, Endocrinology, Biology, GeneTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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52Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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