Cervical spine arthritis as initial manifestation in Juvenile Idiopathic Arthritis: a multicenter retrospective study Article Swipe
Estefanía Quesada‐Masachs
,
Jaime de Inocencio Arocena
,
Juan Carlos Nieto‐González
,
Indalecio Monteagudo Sáez
,
Sara Murías
,
Marta Medrano San Ildefonso
,
Joan Calzada‐Hernández
,
Inmaculada Calvo Penadés
,
Rocío Galindo Zavala
,
Mireia López-Corbeto
,
Jordi Antón
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s12969-025-01161-9
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s12969-025-01161-9
Objective To describe the clinical characteristics, diagnostic findings, treatment, and outcomes of patients with Juvenile Idiopathic Arthritis (JIA) whose initial manifestation was cervical spine arthritis. Methods This retrospective multicenter study reviewed medical records of JIA patients who presented with cervical spine arthritis as the first and only symptom of the disease. Data collected included clinical presentation, imaging findings at diagnosis and follow-up, age at onset, JIA subtype, disease activity, treatment strategies, and clinical outcomes. Results Nine patients were identified, five of whom were classified as having oligoarticular-persistent JIA. The mean age at symptom onset was 4.98 ± 3.08 years, with an average diagnostic delay of 6.98 ± 9.78 months. The most common presenting symptom was torticollis (88.9%), followed by limited cervical range of motion (77.8%) and neck pain (55.6%). Cervical MRI was performed in all cases, demonstrating C1–C2 synovitis in every patient and subluxation in four. Initial treatments included nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, and methotrexate. Seven patients required escalation to biologic therapy with tumor necrosis factor inhibitors (TNFi), and one underwent surgical arthrodesis. Conclusions Cervical spine arthritis may be the sole initial manifestation of JIA and should be considered in children with persistent torticollis. Early MRI evaluation is critical for timely diagnosis and monitoring. The frequent need for TNFi therapy highlights the potentially aggressive nature of this presentation and the importance of early recognition and intervention.
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- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12969-025-01161-9
- https://ped-rheum.biomedcentral.com/counter/pdf/10.1186/s12969-025-01161-9
- OA Status
- gold
- References
- 31
- OpenAlex ID
- https://openalex.org/W4416092995
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https://openalex.org/W4416092995Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s12969-025-01161-9Digital Object Identifier
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Cervical spine arthritis as initial manifestation in Juvenile Idiopathic Arthritis: a multicenter retrospective studyWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
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2025-11-10Full publication date if available
- Authors
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Estefanía Quesada‐Masachs, Jaime de Inocencio Arocena, Juan Carlos Nieto‐González, Indalecio Monteagudo Sáez, Sara Murías, Marta Medrano San Ildefonso, Joan Calzada‐Hernández, Inmaculada Calvo Penadés, Rocío Galindo Zavala, Mireia López-Corbeto, Jordi AntónList of authors in order
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https://doi.org/10.1186/s12969-025-01161-9Publisher landing page
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https://ped-rheum.biomedcentral.com/counter/pdf/10.1186/s12969-025-01161-9Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://ped-rheum.biomedcentral.com/counter/pdf/10.1186/s12969-025-01161-9Direct OA link when available
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