CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cells Article Swipe
Katja Koeppen
,
Amanda Nymon
,
Roxanna Barnaby
,
Zhongyou Li
,
Thomas H. Hampton
,
Alix Ashare
,
Bruce A. Stanton
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1152/ajplung.00621.2020
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1152/ajplung.00621.2020
Mutations in CFTR alter macrophage responses, for example, by reducing their ability to phagocytose and kill bacteria. Altered macrophage responses may facilitate bacterial infection and inflammation in the lungs, contributing to morbidity and mortality in cystic fibrosis (CF). Extracellular vesicles (EVs) are secreted by multiple cell types in the lungs and participate in the host immune response to bacterial infection, but the effect of EVs secreted by CF airway epithelial cells (AEC) on CF macrophages is unknown. This report examines the effect of EVs secreted by primary AEC on monocyte-derived macrophages (MDM) and contrasts responses of CF and wild type (WT) MDM. We found that EVs generally increase pro-inflammatory cytokine secretion and expression of innate immune genes in MDM, especially when EVs are derived from AEC exposed to Pseudomonas aeruginosa and that this effect is attenuated in CF MDM. Specifically, EVs secreted by P. aeruginosa exposed AEC (EV-PA) induced immune response genes and increased secretion of proinflammatory cytokines, chemoattractants, and chemokines involved in tissue repair by WT MDM, but these effects were less robust in CF MDM. We attribute attenuated responses by CF MDM to differences between CF and WT macrophages because EVs secreted by CF AEC or WT AEC elicited similar responses in CF MDM. Our findings demonstrate the importance of AEC EVs in macrophage responses and show that the Phe508del mutation in CFTR attenuates the innate immune response of MDM to EVs.
Related Topics
Concepts
Chemokine
Innate immune system
Immune system
Secretion
Inflammation
Proinflammatory cytokine
Macrophage
Biology
Immunology
Monocyte
Cell biology
Extracellular vesicle
CCL2
Cytokine
Cystic fibrosis
Microbiology
Microvesicles
In vitro
Gene
Biochemistry
microRNA
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1152/ajplung.00621.2020
- OA Status
- green
- Cited By
- 16
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3122894006
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3122894006Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1152/ajplung.00621.2020Digital Object Identifier
- Title
-
CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cellsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-01-20Full publication date if available
- Authors
-
Katja Koeppen, Amanda Nymon, Roxanna Barnaby, Zhongyou Li, Thomas H. Hampton, Alix Ashare, Bruce A. StantonList of authors in order
- Landing page
-
https://doi.org/10.1152/ajplung.00621.2020Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/8238154Direct OA link when available
- Concepts
-
Chemokine, Innate immune system, Immune system, Secretion, Inflammation, Proinflammatory cytokine, Macrophage, Biology, Immunology, Monocyte, Cell biology, Extracellular vesicle, CCL2, Cytokine, Cystic fibrosis, Microbiology, Microvesicles, In vitro, Gene, Biochemistry, microRNA, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
16Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 3, 2023: 6, 2022: 3, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
60Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Our | 206 |
| abstract_inverted_index.and | 14, 24, 32, 50, 92, 97, 111, 130, 152, 159, 188, 217 |
| abstract_inverted_index.are | 41, 122 |
| abstract_inverted_index.but | 60, 168 |
| abstract_inverted_index.for | 6 |
| abstract_inverted_index.may | 20 |
| abstract_inverted_index.the | 27, 48, 53, 61, 80, 209, 220, 226 |
| abstract_inverted_index.(WT) | 100 |
| abstract_inverted_index.CFTR | 2, 224 |
| abstract_inverted_index.EVs. | 233 |
| abstract_inverted_index.MDM, | 118, 167 |
| abstract_inverted_index.MDM. | 101, 138, 176, 205 |
| abstract_inverted_index.This | 77 |
| abstract_inverted_index.cell | 45 |
| abstract_inverted_index.from | 124 |
| abstract_inverted_index.host | 54 |
| abstract_inverted_index.kill | 15 |
| abstract_inverted_index.less | 172 |
| abstract_inverted_index.show | 218 |
| abstract_inverted_index.that | 104, 131, 219 |
| abstract_inverted_index.this | 132 |
| abstract_inverted_index.type | 99 |
| abstract_inverted_index.were | 171 |
| abstract_inverted_index.when | 120 |
| abstract_inverted_index.wild | 98 |
| abstract_inverted_index.(AEC) | 71 |
| abstract_inverted_index.(CF). | 37 |
| abstract_inverted_index.(EVs) | 40 |
| abstract_inverted_index.(MDM) | 91 |
| abstract_inverted_index.alter | 3 |
| abstract_inverted_index.cells | 70 |
| abstract_inverted_index.found | 103 |
| abstract_inverted_index.genes | 116, 151 |
| abstract_inverted_index.lungs | 49 |
| abstract_inverted_index.their | 10 |
| abstract_inverted_index.these | 169 |
| abstract_inverted_index.types | 46 |
| abstract_inverted_index.airway | 68 |
| abstract_inverted_index.cystic | 35 |
| abstract_inverted_index.effect | 62, 81, 133 |
| abstract_inverted_index.immune | 55, 115, 149, 228 |
| abstract_inverted_index.innate | 114, 227 |
| abstract_inverted_index.lungs, | 28 |
| abstract_inverted_index.repair | 164 |
| abstract_inverted_index.report | 78 |
| abstract_inverted_index.robust | 173 |
| abstract_inverted_index.tissue | 163 |
| abstract_inverted_index.(EV-PA) | 147 |
| abstract_inverted_index.Altered | 17 |
| abstract_inverted_index.ability | 11 |
| abstract_inverted_index.because | 191 |
| abstract_inverted_index.between | 186 |
| abstract_inverted_index.derived | 123 |
| abstract_inverted_index.effects | 170 |
| abstract_inverted_index.exposed | 126, 145 |
| abstract_inverted_index.induced | 148 |
| abstract_inverted_index.primary | 86 |
| abstract_inverted_index.similar | 201 |
| abstract_inverted_index.cytokine | 109 |
| abstract_inverted_index.elicited | 200 |
| abstract_inverted_index.examines | 79 |
| abstract_inverted_index.example, | 7 |
| abstract_inverted_index.fibrosis | 36 |
| abstract_inverted_index.findings | 207 |
| abstract_inverted_index.increase | 107 |
| abstract_inverted_index.involved | 161 |
| abstract_inverted_index.multiple | 44 |
| abstract_inverted_index.mutation | 222 |
| abstract_inverted_index.reducing | 9 |
| abstract_inverted_index.response | 56, 150, 229 |
| abstract_inverted_index.secreted | 42, 65, 84, 141, 193 |
| abstract_inverted_index.unknown. | 76 |
| abstract_inverted_index.vesicles | 39 |
| abstract_inverted_index.Mutations | 0 |
| abstract_inverted_index.Phe508del | 221 |
| abstract_inverted_index.attribute | 178 |
| abstract_inverted_index.bacteria. | 16 |
| abstract_inverted_index.bacterial | 22, 58 |
| abstract_inverted_index.contrasts | 93 |
| abstract_inverted_index.generally | 106 |
| abstract_inverted_index.increased | 153 |
| abstract_inverted_index.infection | 23 |
| abstract_inverted_index.morbidity | 31 |
| abstract_inverted_index.mortality | 33 |
| abstract_inverted_index.responses | 19, 94, 180, 202, 216 |
| abstract_inverted_index.secretion | 110, 154 |
| abstract_inverted_index.aeruginosa | 129, 144 |
| abstract_inverted_index.attenuated | 135, 179 |
| abstract_inverted_index.attenuates | 225 |
| abstract_inverted_index.chemokines | 160 |
| abstract_inverted_index.cytokines, | 157 |
| abstract_inverted_index.epithelial | 69 |
| abstract_inverted_index.especially | 119 |
| abstract_inverted_index.expression | 112 |
| abstract_inverted_index.facilitate | 21 |
| abstract_inverted_index.importance | 210 |
| abstract_inverted_index.infection, | 59 |
| abstract_inverted_index.macrophage | 4, 18, 215 |
| abstract_inverted_index.responses, | 5 |
| abstract_inverted_index.Pseudomonas | 128 |
| abstract_inverted_index.demonstrate | 208 |
| abstract_inverted_index.differences | 185 |
| abstract_inverted_index.macrophages | 74, 90, 190 |
| abstract_inverted_index.participate | 51 |
| abstract_inverted_index.phagocytose | 13 |
| abstract_inverted_index.contributing | 29 |
| abstract_inverted_index.inflammation | 25 |
| abstract_inverted_index.Extracellular | 38 |
| abstract_inverted_index.Specifically, | 139 |
| abstract_inverted_index.proinflammatory | 156 |
| abstract_inverted_index.monocyte-derived | 89 |
| abstract_inverted_index.pro-inflammatory | 108 |
| abstract_inverted_index.chemoattractants, | 158 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5006474038 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I107672454 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8700000047683716 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.76883373 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |