Challenges of Targeting Tumor Microenvironment in Prostate Cancer Article Swipe
Guoliang Li
,
Zhenbang Chen
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.5772/intechopen.1005744
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.5772/intechopen.1005744
Prostate cancer (PCa) is one of the leading causes of cancer-related deaths in American men. PCa patients often die of the aggressive forms of the malignancy at advanced stages such as distant metastasis. There are urgent need to understand the molecular mechanisms driving PCa progression and subsequently develop efficient therapeutics to improve men’s health in the US as well as the world. Tumor microenvironment (TME) has been realized to play a critical role in PCa progression and metastasis, and targeting key factors of the TME has become the logical strategy for efficiently controlling PCa malignancy. Stromal cells in prostate tumors secrete growth factors, cytokines, and extracellular matrix (ECM) proteins that provide the TME to fuel cell proliferation, invasion, and metastasis. This review will focus on several key factors influencing TME, which include cancer-associated fibroblasts (CAFs), ECM remodeling, androgen receptor (AR) signaling, inflammation, and hypoxia. We will explain and analyze the biological roles of these factors and their important contributions to PCa malignancy, targeted therapeutics, and drug resistance. Furthermore, we will discuss the contributions of the dysregulation of epigenetic regulators to the complexity of the TME in PCa.
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Metadata
- Type
- book-chapter
- Language
- en
- Landing Page
- https://doi.org/10.5772/intechopen.1005744
- https://www.intechopen.com/citation-pdf-url/1188103
- OA Status
- hybrid
- Cited By
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- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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- DOI
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https://doi.org/10.5772/intechopen.1005744Digital Object Identifier
- Title
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Challenges of Targeting Tumor Microenvironment in Prostate CancerWork title
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book-chapterOpenAlex work type
- Language
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enPrimary language
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2024Year of publication
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2024-08-14Full publication date if available
- Authors
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Guoliang Li, Zhenbang ChenList of authors in order
- Landing page
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https://doi.org/10.5772/intechopen.1005744Publisher landing page
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https://www.intechopen.com/citation-pdf-url/1188103Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://www.intechopen.com/citation-pdf-url/1188103Direct OA link when available
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Prostate cancer, Tumor microenvironment, Metastasis, Stromal cell, Cancer research, Malignancy, Extracellular matrix, Cancer, Tumor progression, Epigenetics, Androgen receptor, Medicine, Biology, Internal medicine, Cell biology, Tumor cells, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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