Chamomile and Urtica dioica extracts improve immunological and histological alterations associated with polycystic ovarian syndrome in DHEA -induced mice Article Swipe
Maryam Shamsi
,
Ali Ganji
,
Ghasem Mosayebi
,
Ensieh Seif Amirhoseiny
,
Sepideh Shohani
,
Ali Ghazavi
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1186/s12906-023-03936-7
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1186/s12906-023-03936-7
Background One of the novel mechanisms in the pathogenesis of Polycystic ovary syndrome (PCOS) is low-grade chronic inflammation. Chamomile (Matricaria recutita L.) and Nettle (Urtica dioica), with phytoestrogenic and antioxidant properties, are traditionally used to treat gynecological diseases. This study investigated the immune-modulating effects of these two plants. Methods Following the induction of PCOS by subcutaneous injection (SC) of Dehydroepiandrosterone (DHEA) in BALB / C mice. Mice were treated in five groups: Sham, PCOS, PCOS + Chamomile, PCOS + Nettle, and PCOS + Chamomile and Nettle for 21 days. Ovarian morphology, blood antioxidant capacity, the abundance of Treg cells, and expression of matrix metalloproteinase-9 (MMP-9), transforming growth factor-ß (TGF-ß), cyclooxygenase-2 genes (COX-2), and tumor necrosis factor-alpha (TNF-α) were measured. Results Folliculogenesis, Cystic follicles, and corpus luteum improved in the treatment groups (P < 0. 05). Treg cells in the DHEA group were significantly reduced compared to the Sham group (P < 0. 01). However, this decrease was not corrected in treatment groups (P > 0. 05). Total serum antioxidant capacity was significantly increased in the treatment group of Nettle and Chamomile + Nettle (P < 0. 05). The expression of MMP9 and TGFβ genes in the PCOS group was significantly higher than the Sham group (P < 0. 05), which the expression of MMP9 was corrected by treatment with Chamomile + Nettle extract (P < 0. 05). Conclusion Chamomile and Nettle extract may be an effective supplement in improving the histological and immunological changes of PCOS. However, more research is needed to confirm its effectiveness in humans.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12906-023-03936-7
- https://bmccomplementmedtherapies.biomedcentral.com/counter/pdf/10.1186/s12906-023-03936-7
- OA Status
- gold
- Cited By
- 9
- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W4362522351
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4362522351Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s12906-023-03936-7Digital Object Identifier
- Title
-
Chamomile and Urtica dioica extracts improve immunological and histological alterations associated with polycystic ovarian syndrome in DHEA -induced miceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-04-03Full publication date if available
- Authors
-
Maryam Shamsi, Ali Ganji, Ghasem Mosayebi, Ensieh Seif Amirhoseiny, Sepideh Shohani, Ali GhazaviList of authors in order
- Landing page
-
https://doi.org/10.1186/s12906-023-03936-7Publisher landing page
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https://bmccomplementmedtherapies.biomedcentral.com/counter/pdf/10.1186/s12906-023-03936-7Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://bmccomplementmedtherapies.biomedcentral.com/counter/pdf/10.1186/s12906-023-03936-7Direct OA link when available
- Concepts
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Urtica dioica, Polycystic ovary, Endocrinology, Internal medicine, Medicine, Matricaria chamomilla, Anti-Müllerian hormone, Hormone, Traditional medicine, Diabetes mellitus, Insulin resistanceTop concepts (fields/topics) attached by OpenAlex
- Cited by
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9Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 4, 2023: 2Per-year citation counts (last 5 years)
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59Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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