Changed expression of placental transporters and disrupted epigenetic patterns in a rat model of schizophrenia Article Swipe
Péter Szatmári
,
Gabriella Kékesi
,
Gyöngyi Horváth
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2025.1673124
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2025.1673124
Introduction Generally, the pregnant women with schizophrenia have higher consumption of medicinal drugs. During pregnancy, placental ABC transporters regulate drug disposition and are involved in fetal and placental development. This study examined the expression and function of placental P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) transporters in vivo and evaluated the epigenetic impact of schizophrenia on the placenta in a rat model. Methods The expression of placental P-gp and BCRP was measured by RT-PCR and Western blot techniques in schizophrenia-like Wisket and control Wistar rats on gestation days 15, 18, 20, 21, and 22, while the histone acetyltransferase activity and global methylation state of the placenta were detected by colorimetric kits. Fexofenadine was administered per os (10 mg/kg) to pregnant rats and plasma concentrations of fexofenadine were determined with HPLC analysis on the 21 and 22 days of gestation. Results Reduced placental P-gp expression was identified in late pregnancy, while the placental BCRP expression upregulation was observed before term in schizophrenia. Significantly lower fetal fexofenadine plasma concentration was measured on the 21st and 22nd days of pregnancy compared to the mother; in contrast, the fexofenadine concentration was similar in the schizophrenia-like mother and fetus. Decreased placental histone acetyltransferase activity and DNA hypermethylation were revealed before term in schizophrenia-like rats. Conclusion Based on our results, we can conclude that the expression and function of the placental efflux proteins we examined are altered in schizophrenia, and possibly as a result, altered substrate concentrations were measured in the fetuses. We hypothesize that the altered protein expression may also be a result of the disease-induced epigenetic pattern changes. This study presents novel disease-associated placental ABC transporter alterations, which highlights the dangers of using transporter substrates, especially P-gp, during pregnancy.
Related Topics
Concepts
No concepts available.
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphar.2025.1673124
- https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1673124/pdf
- OA Status
- gold
- References
- 80
- OpenAlex ID
- https://openalex.org/W4416195684
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4416195684Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fphar.2025.1673124Digital Object Identifier
- Title
-
Changed expression of placental transporters and disrupted epigenetic patterns in a rat model of schizophreniaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-13Full publication date if available
- Authors
-
Péter Szatmári, Gabriella Kékesi, Gyöngyi HorváthList of authors in order
- Landing page
-
https://doi.org/10.3389/fphar.2025.1673124Publisher landing page
- PDF URL
-
https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1673124/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1673124/pdfDirect OA link when available
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
80Number of works referenced by this work
Full payload
| id | https://openalex.org/W4416195684 |
|---|---|
| doi | https://doi.org/10.3389/fphar.2025.1673124 |
| ids.doi | https://doi.org/10.3389/fphar.2025.1673124 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/41322281 |
| ids.openalex | https://openalex.org/W4416195684 |
| fwci | |
| type | article |
| title | Changed expression of placental transporters and disrupted epigenetic patterns in a rat model of schizophrenia |
| biblio.issue | |
| biblio.volume | 16 |
| biblio.last_page | 1673124 |
| biblio.first_page | 1673124 |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 2950 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2950 |
| language | en |
| locations[0].id | doi:10.3389/fphar.2025.1673124 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S132108250 |
| locations[0].source.issn | 1663-9812 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1663-9812 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Pharmacology |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_lineage_names | Frontiers Media |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1673124/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Pharmacology |
| locations[0].landing_page_url | https://doi.org/10.3389/fphar.2025.1673124 |
| locations[1].id | pmid:41322281 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in pharmacology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/41322281 |
| locations[2].id | pmh:oai:doaj.org/article:4f593436dfdf42a88db23c9439799ab3 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Frontiers in Pharmacology, Vol 16 (2025) |
| locations[2].landing_page_url | https://doaj.org/article/4f593436dfdf42a88db23c9439799ab3 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5040305477 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-1763-067X |
| authorships[0].author.display_name | Péter Szatmári |
| authorships[0].countries | HU |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I227486990 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary |
| authorships[0].institutions[0].id | https://openalex.org/I227486990 |
| authorships[0].institutions[0].ror | https://ror.org/01pnej532 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I227486990 |
| authorships[0].institutions[0].country_code | HU |
| authorships[0].institutions[0].display_name | University of Szeged |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Péter Szatmári |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary |
| authorships[1].author.id | https://openalex.org/A5055362431 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-0185-2155 |
| authorships[1].author.display_name | Gabriella Kékesi |
| authorships[1].countries | HU |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I227486990 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Physiology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary |
| authorships[1].institutions[0].id | https://openalex.org/I227486990 |
| authorships[1].institutions[0].ror | https://ror.org/01pnej532 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I227486990 |
| authorships[1].institutions[0].country_code | HU |
| authorships[1].institutions[0].display_name | University of Szeged |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Gabriella Kékesi |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Physiology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary |
| authorships[2].author.id | https://openalex.org/A5009424616 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-6025-4577 |
| authorships[2].author.display_name | Gyöngyi Horváth |
| authorships[2].countries | HU |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I227486990 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Physiology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary |
| authorships[2].institutions[0].id | https://openalex.org/I227486990 |
| authorships[2].institutions[0].ror | https://ror.org/01pnej532 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I227486990 |
| authorships[2].institutions[0].country_code | HU |
| authorships[2].institutions[0].display_name | University of Szeged |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Gyöngyi Horváth |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Physiology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1673124/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-11-13T00:00:00 |
| display_name | Changed expression of placental transporters and disrupted epigenetic patterns in a rat model of schizophrenia |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-28T07:30:46.452191 |
| primary_topic | |
| cited_by_count | 0 |
| locations_count | 3 |
| best_oa_location.id | doi:10.3389/fphar.2025.1673124 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S132108250 |
| best_oa_location.source.issn | 1663-9812 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1663-9812 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Pharmacology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_lineage_names | Frontiers Media |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1673124/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Pharmacology |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fphar.2025.1673124 |
| primary_location.id | doi:10.3389/fphar.2025.1673124 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S132108250 |
| primary_location.source.issn | 1663-9812 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1663-9812 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Pharmacology |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_lineage_names | Frontiers Media |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1673124/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Pharmacology |
| primary_location.landing_page_url | https://doi.org/10.3389/fphar.2025.1673124 |
| publication_date | 2025-11-13 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W3030764315, https://openalex.org/W2169296989, https://openalex.org/W2911396688, https://openalex.org/W2023340590, https://openalex.org/W2884080831, https://openalex.org/W3007227522, https://openalex.org/W2134812217, https://openalex.org/W3084259215, https://openalex.org/W2011530842, https://openalex.org/W4400293387, https://openalex.org/W2972824839, https://openalex.org/W351118931, https://openalex.org/W2596741853, https://openalex.org/W3134359440, https://openalex.org/W4392051437, https://openalex.org/W3001577803, https://openalex.org/W4205160876, https://openalex.org/W101048417, https://openalex.org/W2996472004, https://openalex.org/W2804552830, https://openalex.org/W3197426932, https://openalex.org/W1537856377, https://openalex.org/W2913049662, https://openalex.org/W4210291502, https://openalex.org/W4200346158, https://openalex.org/W4406274802, https://openalex.org/W3048717461, https://openalex.org/W4291020606, https://openalex.org/W2161787769, https://openalex.org/W4225885267, https://openalex.org/W2061191951, https://openalex.org/W2014746488, https://openalex.org/W4205731767, https://openalex.org/W2083418897, https://openalex.org/W2140677989, https://openalex.org/W3088859120, https://openalex.org/W3129841130, https://openalex.org/W3159555860, https://openalex.org/W4412494009, https://openalex.org/W4389625788, https://openalex.org/W4226139093, https://openalex.org/W4311086694, https://openalex.org/W4399851190, https://openalex.org/W4388837418, https://openalex.org/W1976583362, https://openalex.org/W1967638617, https://openalex.org/W3152045758, https://openalex.org/W4323348304, https://openalex.org/W1973033693, https://openalex.org/W2502871139, https://openalex.org/W3015736365, https://openalex.org/W4386775651, https://openalex.org/W2166153381, https://openalex.org/W2070029284, https://openalex.org/W3028203807, https://openalex.org/W2997020876, https://openalex.org/W2055437362, https://openalex.org/W4385307960, https://openalex.org/W2135077376, https://openalex.org/W2810450038, https://openalex.org/W2120908557, https://openalex.org/W4386092002, https://openalex.org/W4412516338, https://openalex.org/W4404126747, https://openalex.org/W2752442249, https://openalex.org/W2795999196, https://openalex.org/W4400843159, https://openalex.org/W1850975479, https://openalex.org/W4411288892, https://openalex.org/W2160655220, https://openalex.org/W2150479788, https://openalex.org/W4200082871, https://openalex.org/W2740094929, https://openalex.org/W4409149815, https://openalex.org/W2166181473, https://openalex.org/W2039877764, https://openalex.org/W3093377868, https://openalex.org/W4414037846, https://openalex.org/W2044935825, https://openalex.org/W2156157049 |
| referenced_works_count | 80 |
| abstract_inverted_index.a | 60, 237, 257 |
| abstract_inverted_index.21 | 134 |
| abstract_inverted_index.22 | 136 |
| abstract_inverted_index.We | 247 |
| abstract_inverted_index.as | 236 |
| abstract_inverted_index.be | 256 |
| abstract_inverted_index.by | 73, 109 |
| abstract_inverted_index.in | 24, 47, 59, 79, 147, 160, 182, 189, 207, 232, 244 |
| abstract_inverted_index.of | 10, 36, 54, 66, 104, 125, 138, 176, 223, 259, 278 |
| abstract_inverted_index.on | 56, 86, 132, 170, 212 |
| abstract_inverted_index.os | 116 |
| abstract_inverted_index.to | 119, 179 |
| abstract_inverted_index.we | 215, 228 |
| abstract_inverted_index.(10 | 117 |
| abstract_inverted_index.15, | 89 |
| abstract_inverted_index.18, | 90 |
| abstract_inverted_index.20, | 91 |
| abstract_inverted_index.21, | 92 |
| abstract_inverted_index.22, | 94 |
| abstract_inverted_index.ABC | 16, 271 |
| abstract_inverted_index.DNA | 201 |
| abstract_inverted_index.The | 64 |
| abstract_inverted_index.and | 21, 26, 34, 40, 49, 69, 75, 82, 93, 100, 122, 135, 173, 193, 200, 221, 234 |
| abstract_inverted_index.are | 22, 230 |
| abstract_inverted_index.can | 216 |
| abstract_inverted_index.may | 254 |
| abstract_inverted_index.our | 213 |
| abstract_inverted_index.per | 115 |
| abstract_inverted_index.rat | 61 |
| abstract_inverted_index.the | 2, 32, 51, 57, 96, 105, 133, 151, 171, 180, 184, 190, 219, 224, 245, 250, 260, 276 |
| abstract_inverted_index.was | 71, 113, 145, 156, 168, 187 |
| abstract_inverted_index.21st | 172 |
| abstract_inverted_index.22nd | 174 |
| abstract_inverted_index.BCRP | 70, 153 |
| abstract_inverted_index.HPLC | 130 |
| abstract_inverted_index.P-gp | 68, 143 |
| abstract_inverted_index.This | 29, 265 |
| abstract_inverted_index.also | 255 |
| abstract_inverted_index.blot | 77 |
| abstract_inverted_index.days | 88, 137, 175 |
| abstract_inverted_index.drug | 19 |
| abstract_inverted_index.have | 7 |
| abstract_inverted_index.late | 148 |
| abstract_inverted_index.rats | 85, 121 |
| abstract_inverted_index.term | 159, 206 |
| abstract_inverted_index.that | 218, 249 |
| abstract_inverted_index.vivo | 48 |
| abstract_inverted_index.were | 107, 127, 203, 242 |
| abstract_inverted_index.with | 5, 129 |
| abstract_inverted_index.Based | 211 |
| abstract_inverted_index.P-gp, | 283 |
| abstract_inverted_index.fetal | 25, 164 |
| abstract_inverted_index.kits. | 111 |
| abstract_inverted_index.lower | 163 |
| abstract_inverted_index.novel | 268 |
| abstract_inverted_index.rats. | 209 |
| abstract_inverted_index.state | 103 |
| abstract_inverted_index.study | 30, 266 |
| abstract_inverted_index.using | 279 |
| abstract_inverted_index.which | 274 |
| abstract_inverted_index.while | 95, 150 |
| abstract_inverted_index.women | 4 |
| abstract_inverted_index.(BCRP) | 45 |
| abstract_inverted_index.(P-gp) | 39 |
| abstract_inverted_index.During | 13 |
| abstract_inverted_index.RT-PCR | 74 |
| abstract_inverted_index.Wisket | 81 |
| abstract_inverted_index.Wistar | 84 |
| abstract_inverted_index.before | 158, 205 |
| abstract_inverted_index.breast | 41 |
| abstract_inverted_index.cancer | 42 |
| abstract_inverted_index.drugs. | 12 |
| abstract_inverted_index.during | 284 |
| abstract_inverted_index.efflux | 226 |
| abstract_inverted_index.fetus. | 194 |
| abstract_inverted_index.global | 101 |
| abstract_inverted_index.higher | 8 |
| abstract_inverted_index.impact | 53 |
| abstract_inverted_index.mg/kg) | 118 |
| abstract_inverted_index.model. | 62 |
| abstract_inverted_index.mother | 192 |
| abstract_inverted_index.plasma | 123, 166 |
| abstract_inverted_index.result | 258 |
| abstract_inverted_index.Methods | 63 |
| abstract_inverted_index.Reduced | 141 |
| abstract_inverted_index.Results | 140 |
| abstract_inverted_index.Western | 76 |
| abstract_inverted_index.altered | 231, 239, 251 |
| abstract_inverted_index.control | 83 |
| abstract_inverted_index.dangers | 277 |
| abstract_inverted_index.histone | 97, 197 |
| abstract_inverted_index.mother; | 181 |
| abstract_inverted_index.pattern | 263 |
| abstract_inverted_index.protein | 44, 252 |
| abstract_inverted_index.result, | 238 |
| abstract_inverted_index.similar | 188 |
| abstract_inverted_index.activity | 99, 199 |
| abstract_inverted_index.analysis | 131 |
| abstract_inverted_index.changes. | 264 |
| abstract_inverted_index.compared | 178 |
| abstract_inverted_index.conclude | 217 |
| abstract_inverted_index.detected | 108 |
| abstract_inverted_index.examined | 31, 229 |
| abstract_inverted_index.fetuses. | 246 |
| abstract_inverted_index.function | 35, 222 |
| abstract_inverted_index.involved | 23 |
| abstract_inverted_index.measured | 72, 169, 243 |
| abstract_inverted_index.observed | 157 |
| abstract_inverted_index.placenta | 58, 106 |
| abstract_inverted_index.possibly | 235 |
| abstract_inverted_index.pregnant | 3, 120 |
| abstract_inverted_index.presents | 267 |
| abstract_inverted_index.proteins | 227 |
| abstract_inverted_index.regulate | 18 |
| abstract_inverted_index.results, | 214 |
| abstract_inverted_index.revealed | 204 |
| abstract_inverted_index.Decreased | 195 |
| abstract_inverted_index.contrast, | 183 |
| abstract_inverted_index.evaluated | 50 |
| abstract_inverted_index.gestation | 87 |
| abstract_inverted_index.medicinal | 11 |
| abstract_inverted_index.placental | 15, 27, 37, 67, 142, 152, 196, 225, 270 |
| abstract_inverted_index.pregnancy | 177 |
| abstract_inverted_index.substrate | 240 |
| abstract_inverted_index.Conclusion | 210 |
| abstract_inverted_index.Generally, | 1 |
| abstract_inverted_index.determined | 128 |
| abstract_inverted_index.epigenetic | 52, 262 |
| abstract_inverted_index.especially | 282 |
| abstract_inverted_index.expression | 33, 65, 144, 154, 220, 253 |
| abstract_inverted_index.gestation. | 139 |
| abstract_inverted_index.highlights | 275 |
| abstract_inverted_index.identified | 146 |
| abstract_inverted_index.pregnancy, | 14, 149 |
| abstract_inverted_index.pregnancy. | 285 |
| abstract_inverted_index.resistance | 43 |
| abstract_inverted_index.techniques | 78 |
| abstract_inverted_index.consumption | 9 |
| abstract_inverted_index.disposition | 20 |
| abstract_inverted_index.hypothesize | 248 |
| abstract_inverted_index.methylation | 102 |
| abstract_inverted_index.substrates, | 281 |
| abstract_inverted_index.transporter | 272, 280 |
| abstract_inverted_index.Fexofenadine | 112 |
| abstract_inverted_index.Introduction | 0 |
| abstract_inverted_index.administered | 114 |
| abstract_inverted_index.alterations, | 273 |
| abstract_inverted_index.colorimetric | 110 |
| abstract_inverted_index.development. | 28 |
| abstract_inverted_index.fexofenadine | 126, 165, 185 |
| abstract_inverted_index.transporters | 17, 46 |
| abstract_inverted_index.upregulation | 155 |
| abstract_inverted_index.Significantly | 162 |
| abstract_inverted_index.concentration | 167, 186 |
| abstract_inverted_index.schizophrenia | 6, 55 |
| abstract_inverted_index.P-glycoprotein | 38 |
| abstract_inverted_index.concentrations | 124, 241 |
| abstract_inverted_index.schizophrenia, | 233 |
| abstract_inverted_index.schizophrenia. | 161 |
| abstract_inverted_index.disease-induced | 261 |
| abstract_inverted_index.hypermethylation | 202 |
| abstract_inverted_index.acetyltransferase | 98, 198 |
| abstract_inverted_index.disease-associated | 269 |
| abstract_inverted_index.schizophrenia-like | 80, 191, 208 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 3 |
| citation_normalized_percentile |