Changes in CD4+ T cells subsets in patients with alcohol-related cirrhosis Article Swipe
Paola Zuluaga
,
Coral Zurera-Egea
,
Daniel G. Fuster
,
Anna Hernández‐Rubio
,
Aina Teniente‐Serra
,
Eva Martínez‐Cáceres
,
Roberto Muga
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s10238-024-01548-0
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s10238-024-01548-0
Alcohol-related cirrhosis (AC) is a condition that impacts in immunity. We analyzed changes over time in CD4 + subsets in AC-patients. We included patients with alcohol use disorder admitted at least twice for treatment. Patients without evidence of liver disease were the control group (CG). We analyzed naïve, memory, TEMRA, Th1, Th2, Th17, early activated, and late activated subsets. During the follow-up, TEMRA T cells were increased (1.2 ± 1.1% vs. 2.1 ± 1.1%, p = 0.03) in AC-patients ( n = 5) and Th17 cells were decreased (14.1 ± 4.3% vs. 12.3 ± 6.4%, p = 0.03) in the CG ( n = 22). Late activated cells were associated with a decrease in memory cells in both the groups. This association was stronger in AC-patients ( r = − 0.90, p = 0.04). The proportion of memory cells was correlated with an increased of Th1/Th2/Th17 cells in the CG ( r = 0.70, r = 0.68, r = 0.63; p < 0.01, respectively), whereas in AC-patients was correlated with a decrease in Th17 cells ( r = − 0.90, p = 0.03). AC-patients showed an increase in the proportion of TEMRA T cells, loss of heterogeneity and decreased CD4 + differentiation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s10238-024-01548-0
- https://link.springer.com/content/pdf/10.1007/s10238-024-01548-0.pdf
- OA Status
- hybrid
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406070495
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406070495Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1007/s10238-024-01548-0Digital Object Identifier
- Title
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Changes in CD4+ T cells subsets in patients with alcohol-related cirrhosisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-05Full publication date if available
- Authors
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Paola Zuluaga, Coral Zurera-Egea, Daniel G. Fuster, Anna Hernández‐Rubio, Aina Teniente‐Serra, Eva Martínez‐Cáceres, Roberto MugaList of authors in order
- Landing page
-
https://doi.org/10.1007/s10238-024-01548-0Publisher landing page
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https://link.springer.com/content/pdf/10.1007/s10238-024-01548-0.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://link.springer.com/content/pdf/10.1007/s10238-024-01548-0.pdfDirect OA link when available
- Concepts
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Hematology, Cirrhosis, Internal medicine, Alcohol, Alcoholic liver disease, Medicine, Immunology, Immunity, Gastroenterology, Endocrinology, Immune system, Chemistry, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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26Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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