Changes in the Use of Antibiotics for Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Children: A 5-Year Retrospective, Single Center Study Article Swipe
Maria Sole Valentino
,
Paola Borgia
,
Virginia Deut
,
Ines Lorenzi
,
Paola Barabino
,
Elisabetta Ugolotti
,
Marcello Mariani
,
Francesca Bagnasco
,
Elio Castagnola
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/antibiotics12020216
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/antibiotics12020216
Monitoring antibiotic use in the pediatric population is a challenge, especially when determining a relationship between specific pathogens, infections, and antibiotic use. We retrospectively analyzed the consumption of anti-methicillin-resistant Staphylococcus aureus (MRSA) drugs from 2017 to 2021 at Istituto Giannina Gaslini by means of defined daily dose (DDD) adopted for adults by World Health Organization. We observed a statistically significant increase in the use of daptomycin and ceftaroline, combined with a decrease in the use of vancomycin. In the same period, we observed an increase in the proportion of bloodstream infections due to MRSA with vancomycin minimally inhibitory concentration (MIC mg/L) = 1, that represented the 100% of cases in 2021. This aspect was combined with the observation that in the 59% of cases, where vancomycin plasma concentrations were evaluated, it was not possible to achieve a ratio of the 24-h area under the concentration–time curve and MIC (AUC0–24/MIC) of vancomycin ≥ 400 mg/L. This study confirms that DDD can be used in pediatrics to monitor antibiotic consumption in relationship with infections epidemiology. Moreover, it describes the presence of vancomycin MIC creep for MRSA also in pediatrics and the difficulties in obtaining effective vancomycin plasma concentrations in children.
Related Topics
Concepts
Vancomycin
Medicine
Daptomycin
Antibiotics
Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus
Minimum inhibitory concentration
Epidemiology
Bacteremia
Retrospective cohort study
Population
Microbiology
Pediatrics
Internal medicine
Biology
Bacteria
Environmental health
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antibiotics12020216
- https://www.mdpi.com/2079-6382/12/2/216/pdf?version=1674184008
- OA Status
- gold
- Cited By
- 4
- References
- 20
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4317608736
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4317608736Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/antibiotics12020216Digital Object Identifier
- Title
-
Changes in the Use of Antibiotics for Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Children: A 5-Year Retrospective, Single Center StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-20Full publication date if available
- Authors
-
Maria Sole Valentino, Paola Borgia, Virginia Deut, Ines Lorenzi, Paola Barabino, Elisabetta Ugolotti, Marcello Mariani, Francesca Bagnasco, Elio CastagnolaList of authors in order
- Landing page
-
https://doi.org/10.3390/antibiotics12020216Publisher landing page
- PDF URL
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https://www.mdpi.com/2079-6382/12/2/216/pdf?version=1674184008Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2079-6382/12/2/216/pdf?version=1674184008Direct OA link when available
- Concepts
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Vancomycin, Medicine, Daptomycin, Antibiotics, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, Minimum inhibitory concentration, Epidemiology, Bacteremia, Retrospective cohort study, Population, Microbiology, Pediatrics, Internal medicine, Biology, Bacteria, Environmental health, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
20Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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