Changes in the Use of Fresh-Frozen Plasma Transfusions in Preterm Neonates: A Single Center Experience Article Swipe
Nina A. M. Houben
,
Lisanne E. Heeger
,
Simon Stanworth
,
Helen V. New
,
Johanna G. van der Bom
,
Suzanne Fustolo‐Gunnink
,
Enrico Lopriore
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/jcm9113789
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/jcm9113789
The aim of this study was to evaluate changes in the use of fresh-frozen plasma (FFP) transfusions and the use of clotting tests in preterm neonates in our center over the past two decades. In this retrospective cohort analysis, we included all consecutive neonates with a gestational age at birth between 24 + 0 and 31 + 6 weeks admitted to our neonatal intensive care unit (NICU) between 2004 and 2019. We divided all included neonates into three consecutive time epochs according to date of birth: January 2004 to April 2009, May 2009 to August 2014 and September 2014 to December 2019. The main outcomes were the use of FFP transfusion, coagulation testing and the indications for FFP transfusion. The percentage of preterm neonates receiving FFP transfusion decreased from 5.7% (47/824) to 3.7% (30/901) to 2.0% (17/852) from the first epoch to the last epoch (p < 0.001). Additionally, the rate of neonates undergoing coagulation testing decreased from 24.3% (200/824) to 14.5% (131/901) to 8% (68/852) over the epochs (p < 0.001). Most FFP transfusions were prescribed prophylactically based on prolongation of activated partial thromboplastin time (aPTT) or prothrombin time (PT) (56%). In conclusion, both the use of FFP transfusions and the use of coagulation tests decreased significantly over the years. The majority of the FFP transfusions were administrated prophylactically for abnormal coagulation tests.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm9113789
- https://www.mdpi.com/2077-0383/9/11/3789/pdf?version=1606278833
- OA Status
- gold
- Cited By
- 14
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3109849314
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3109849314Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/jcm9113789Digital Object Identifier
- Title
-
Changes in the Use of Fresh-Frozen Plasma Transfusions in Preterm Neonates: A Single Center ExperienceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-11-23Full publication date if available
- Authors
-
Nina A. M. Houben, Lisanne E. Heeger, Simon Stanworth, Helen V. New, Johanna G. van der Bom, Suzanne Fustolo‐Gunnink, Enrico LoprioreList of authors in order
- Landing page
-
https://doi.org/10.3390/jcm9113789Publisher landing page
- PDF URL
-
https://www.mdpi.com/2077-0383/9/11/3789/pdf?version=1606278833Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2077-0383/9/11/3789/pdf?version=1606278833Direct OA link when available
- Concepts
-
Medicine, Fresh frozen plasma, Center (category theory), Single Center, Obstetrics, Surgery, Internal medicine, Crystallography, Chemistry, PlateletTop concepts (fields/topics) attached by OpenAlex
- Cited by
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14Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2, 2023: 3, 2022: 7, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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43Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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