Changes in Thyroid Function and Autoimmunity in Older Individuals: Longitudinal Analysis of the Whickham Cohort Article Swipe
Salman Razvi
,
H. Munro
,
Lorna Ingoe
,
Jonathan Vernazza
,
Mark Vanderpump
,
Simon H. S. Pearce
,
Marian Ludgate
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1210/clinem/dgae875
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1210/clinem/dgae875
Background Longitudinal studies of thyroid function have demonstrated differing results. It remains unclear whether changes in thyroid function affect the diagnosis of subclinical thyroid dysfunction with aging. Methods Survivors of the Whickham cohort study were evaluated on 2 occasions between the years 2008 and 2012 and 2016 and 2019. Serum TSH, free T4 (FT4), free T3 (FT3), and thyroid peroxidase antibody (TPOAb) were measured on both occasions using the same assay under similar conditions. Individuals with known thyroid disease or on medications affecting thyroid function were excluded. Comorbidities were noted, functional mobility was assessed by the timed up-and-go test, and muscle function was evaluated by the hand grip strength test. Results In 204 individuals (mean age 77.0 [±6.6] years, 114 [56%] female), followed over a median (interquartile range) of 7.8 (7.3-8.2) years, serum TSH increased by 0.29 mU/L (12.4%), FT3 and TPOAb reduced by 0.1 pmol/L (−2.1%) and 0.6 U/L (−11.2%), and there were no significant changes in FT4 levels. The calculated upper limit of serum TSH increased over the follow-up period from 4.74 mU/L to 6.28 mU/L. The relationship between serum TSH and FT4 at both time points was not significantly different. Utilizing standard laboratory reference ranges, the prevalence of subclinical hypothyroidism increased from 3.5% at baseline to 9.0% at follow-up. However, adopting a visit-specific TSH reference range reduced the prevalence of subclinical hypothyroidism at both time points to 2.0%. Discussion Thyroid function demonstrates subtle but significant changes with age. Utilizing standard reference ranges tends to increase the diagnosis of subclinical hypothyroidism in older euthyroid individuals. Our data suggest that adopting age-appropriate TSH reference ranges may reduce the risk of diagnosing and (potentially unnecessarily) treating subclinical hypothyroidism.
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Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1210/clinem/dgae875
- OA Status
- hybrid
- Cited By
- 1
- References
- 31
- Related Works
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- OpenAlex ID
- https://openalex.org/W4405393500
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405393500Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1210/clinem/dgae875Digital Object Identifier
- Title
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Changes in Thyroid Function and Autoimmunity in Older Individuals: Longitudinal Analysis of the Whickham CohortWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-12-14Full publication date if available
- Authors
-
Salman Razvi, H. Munro, Lorna Ingoe, Jonathan Vernazza, Mark Vanderpump, Simon H. S. Pearce, Marian LudgateList of authors in order
- Landing page
-
https://doi.org/10.1210/clinem/dgae875Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1210/clinem/dgae875Direct OA link when available
- Concepts
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Subclinical infection, Medicine, Thyroid function, Thyroid peroxidase, Internal medicine, Thyroid function tests, Cohort, Triiodothyronine, Thyroid, Endocrinology, Thyroid disease, Free thyroxine, Reference range, Cohort studyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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31Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.disease | 79 |
| abstract_inverted_index.levels. | 160 |
| abstract_inverted_index.ranges, | 198 |
| abstract_inverted_index.reduced | 143, 220 |
| abstract_inverted_index.remains | 12 |
| abstract_inverted_index.similar | 73 |
| abstract_inverted_index.studies | 3 |
| abstract_inverted_index.suggest | 260 |
| abstract_inverted_index.thyroid | 5, 17, 24, 59, 78, 84 |
| abstract_inverted_index.unclear | 13 |
| abstract_inverted_index.whether | 14 |
| abstract_inverted_index.(12.4%), | 139 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.However, | 213 |
| abstract_inverted_index.Whickham | 32 |
| abstract_inverted_index.adopting | 214, 262 |
| abstract_inverted_index.antibody | 61 |
| abstract_inverted_index.assessed | 94 |
| abstract_inverted_index.baseline | 208 |
| abstract_inverted_index.female), | 122 |
| abstract_inverted_index.followed | 123 |
| abstract_inverted_index.function | 6, 18, 85, 102, 234 |
| abstract_inverted_index.increase | 248 |
| abstract_inverted_index.measured | 64 |
| abstract_inverted_index.mobility | 92 |
| abstract_inverted_index.results. | 10 |
| abstract_inverted_index.standard | 195, 243 |
| abstract_inverted_index.strength | 109 |
| abstract_inverted_index.treating | 276 |
| abstract_inverted_index.(7.3-8.2) | 131 |
| abstract_inverted_index.(−2.1%) | 147 |
| abstract_inverted_index.Survivors | 29 |
| abstract_inverted_index.Utilizing | 194, 242 |
| abstract_inverted_index.affecting | 83 |
| abstract_inverted_index.diagnosis | 21, 250 |
| abstract_inverted_index.differing | 9 |
| abstract_inverted_index.euthyroid | 256 |
| abstract_inverted_index.evaluated | 36, 104 |
| abstract_inverted_index.excluded. | 87 |
| abstract_inverted_index.follow-up | 171 |
| abstract_inverted_index.increased | 135, 168, 204 |
| abstract_inverted_index.occasions | 39, 67 |
| abstract_inverted_index.reference | 197, 218, 244, 265 |
| abstract_inverted_index.up-and-go | 98 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Discussion | 232 |
| abstract_inverted_index.calculated | 162 |
| abstract_inverted_index.diagnosing | 272 |
| abstract_inverted_index.different. | 193 |
| abstract_inverted_index.follow-up. | 212 |
| abstract_inverted_index.functional | 91 |
| abstract_inverted_index.laboratory | 196 |
| abstract_inverted_index.peroxidase | 60 |
| abstract_inverted_index.prevalence | 200, 222 |
| abstract_inverted_index.(−11.2%), | 151 |
| abstract_inverted_index.Individuals | 75 |
| abstract_inverted_index.conditions. | 74 |
| abstract_inverted_index.dysfunction | 25 |
| abstract_inverted_index.individuals | 114 |
| abstract_inverted_index.medications | 82 |
| abstract_inverted_index.significant | 156, 238 |
| abstract_inverted_index.subclinical | 23, 202, 224, 252, 277 |
| abstract_inverted_index.(potentially | 274 |
| abstract_inverted_index.Longitudinal | 2 |
| abstract_inverted_index.demonstrated | 8 |
| abstract_inverted_index.demonstrates | 235 |
| abstract_inverted_index.individuals. | 257 |
| abstract_inverted_index.relationship | 180 |
| abstract_inverted_index.Comorbidities | 88 |
| abstract_inverted_index.significantly | 192 |
| abstract_inverted_index.(interquartile | 127 |
| abstract_inverted_index.hypothyroidism | 203, 225, 253 |
| abstract_inverted_index.unnecessarily) | 275 |
| abstract_inverted_index.visit-specific | 216 |
| abstract_inverted_index.age-appropriate | 263 |
| abstract_inverted_index.hypothyroidism. | 278 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7400000095367432 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.72995432 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |