Changes of oscillatory and aperiodic neuronal activity in working memory following anaesthesia: a prospective observational study Article Swipe
Janna D. Lendner
,
Ulrich Harler
,
Jonathan Daume
,
Andreas K. Engel
,
Christian Zöllner
,
Till R. Schneider
,
Marlene Fischer
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.05.13.491765
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.05.13.491765
Background Anaesthesia and surgery can lead to cognitive decline, especially in the elderly. However, to date, the neurophysiological underpinnings of perioperative cognitive decline remain unknown. Methods We included male patients, who were 60 years or older scheduled for elective radical prostatectomy under general anaesthesia. We obtained neuropsychological (NP) tests as well as a visual match-to-sample working memory (WM) task with concomitant 62-channel scalp electroencephalography (EEG) before and after surgery. Results A total number of 26 patients completed neuropsychological assessments and EEG pre- and postoperatively. Behavioural performance declined in the neuropsychological assessment after anaesthesia (total recall; t-tests: t 25 = -3.25, Bonferroni-corrected p = 0.015 d = -0.902), while WM performance showed a dissociation between match and mis-match accuracy ( rmANOVA : match*session F 1,25 = 3.866, p = 0.060). Distinct EEG signatures tracked behavioural performance: Better performance in the NP assessment was correlated with an increase of non-oscillatory (aperiodic) activity, reflecting increased cortical activity ( cluster permutation tests: total recall r = 0.66, p = 0.029, learning slope r = 0.66, p = 0.015), while WM accuracy was tracked by distinct temporally-structured oscillatory theta/alpha (7 – 9 Hz), low beta (14 – 18 Hz) and high beta/gamma (34 – 38 Hz) activity ( cluster permutation tests: matches: p < 0.001, mis-matches: p = 0.022). Conclusions Oscillatory and non-oscillatory (aperiodic) activity in perioperative scalp EEG recordings track distinct features of perioperative cognition. Aperiodic activity provides a novel electrophysiological biomarker to identify patients at risk for developing perioperative neurocognitive decline.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.05.13.491765
- https://www.biorxiv.org/content/biorxiv/early/2022/05/13/2022.05.13.491765.full.pdf
- OA Status
- green
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4280586137
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4280586137Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2022.05.13.491765Digital Object Identifier
- Title
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Changes of oscillatory and aperiodic neuronal activity in working memory following anaesthesia: a prospective observational studyWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-05-13Full publication date if available
- Authors
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Janna D. Lendner, Ulrich Harler, Jonathan Daume, Andreas K. Engel, Christian Zöllner, Till R. Schneider, Marlene FischerList of authors in order
- Landing page
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https://doi.org/10.1101/2022.05.13.491765Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2022/05/13/2022.05.13.491765.full.pdfDirect link to full text PDF
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2022/05/13/2022.05.13.491765.full.pdfDirect OA link when available
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Electroencephalography, Perioperative, Audiology, Anesthesia, Neuropsychology, Cognition, General anaesthesia, Psychology, Effects of sleep deprivation on cognitive performance, Recall, Neurocognitive, Medicine, Neuroscience, Cognitive psychologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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