Characterisation of colorectal cancer by hierarchical clustering analyses for five stroma‐related markers Article Swipe
Sunao Ito
,
Akira Koshino
,
Chengbo Wang
,
Takahiro Otani
,
Masayuki Komura
,
Akane Ueki
,
Shunsuke Kato
,
Hiroki Takahashi
,
Masahide Ebi
,
Naotaka Ogasawara
,
Toyonori Tsuzuki
,
Kenji Kasai
,
Kunio Kasugai
,
Shuji Takiguchi
,
Satoru Takahashi
,
Shingo Inaguma
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/2056-4538.12386
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/2056-4538.12386
Evidence for the tumour‐supporting capacities of the tumour stroma has accumulated rapidly in colorectal cancer (CRC). Tumour stroma is composed of heterogeneous cells and components including cancer‐associated fibroblasts (CAFs), small vessels, immune cells, and extracellular matrix proteins. The present study examined the characteristics of CAFs and collagen, major components of cancer stroma, by immunohistochemistry and Sirius red staining. The expression status of five independent CAF‐related or stromal markers, decorin (DCN), fibroblast activation protein (FAP), podoplanin (PDPN), alpha‐smooth muscle actin (ACTA2), and collagen, and their association with clinicopathological features and clinical outcomes were analysed. Patients with DCN‐high tumours had a significantly worse 5‐year survival rate (57.3% versus 79.0%; p = 0.044). Furthermore, hierarchical clustering analyses for these five markers identified three groups that showed specific characteristics: a solid group (cancer cell‐rich, DCN Low PDPN Low ); a PDPN‐dominant group (DCN Mid PDPN High ); and a DCN‐dominant group (DCN High PDPN Low ), with a significant association with patient survival ( p = 0.0085). Cox proportional hazards model identified the PDPN‐dominant group (hazard ratio = 0.50, 95% CI = 0.26–0.96, p = 0.037) as a potential favourable factor compared with the DCN‐dominant group. Of note, DCN‐dominant tumours showed the most advanced pT stage and contained the lowest number of CD8+ and FOXP3+ immune cells. This study has revealed that immunohistochemistry and special staining of five stromal factors with hierarchical clustering analyses could be used for the prognostication of patients with CRC. Cancer stroma‐targeting therapies may be candidate treatments for patients with CRC.
Related Topics
Concepts
Stroma
Podoplanin
Decorin
Stromal cell
Cancer-Associated Fibroblasts
Colorectal cancer
Immunohistochemistry
Extracellular matrix
Cancer
Pathology
Cancer research
Biology
Oncology
Cancer cell
Internal medicine
Medicine
Cell biology
Proteoglycan
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/2056-4538.12386
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2056-4538.12386
- OA Status
- gold
- Cited By
- 3
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399820824
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4399820824Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/2056-4538.12386Digital Object Identifier
- Title
-
Characterisation of colorectal cancer by hierarchical clustering analyses for five stroma‐related markersWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-06-18Full publication date if available
- Authors
-
Sunao Ito, Akira Koshino, Chengbo Wang, Takahiro Otani, Masayuki Komura, Akane Ueki, Shunsuke Kato, Hiroki Takahashi, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Kenji Kasai, Kunio Kasugai, Shuji Takiguchi, Satoru Takahashi, Shingo InagumaList of authors in order
- Landing page
-
https://doi.org/10.1002/2056-4538.12386Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2056-4538.12386Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2056-4538.12386Direct OA link when available
- Concepts
-
Stroma, Podoplanin, Decorin, Stromal cell, Cancer-Associated Fibroblasts, Colorectal cancer, Immunohistochemistry, Extracellular matrix, Cancer, Pathology, Cancer research, Biology, Oncology, Cancer cell, Internal medicine, Medicine, Cell biology, ProteoglycanTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3Per-year citation counts (last 5 years)
- References (count)
-
58Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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