Characteristics and outcomes of hospitalized adult COVID-19 patients in Georgia Article Swipe
Tengiz Tsertsvadze
,
Marina Ezugbaia
,
Marina Endeladze
,
L Ratiani
,
Neli Javakhishvili
,
Lika Mumladze
,
Manana Khotchava
,
Maiko Janashia
,
Diana Zviadadze
,
Levan Gopodze
,
Alex Gokhelashvili
,
Revaz Metchurchtlishvili
,
Akaki Abutidze
,
Nikoloz Chkhartishvili
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.10.23.20218255
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.10.23.20218255
Objective Describe presenting characteristics of hospitalized patients and explore factors associated with in-hospital mortality during the first wave of pandemic in Georgia. Methods This retrospective study included 582 adult patients admitted to 9 dedicated COVID-19 hospitals as of July 30, 2020 (72% of all hospitalizations). Data were abstracted from medical charts. Factors associated with mortality were evaluated in multivariable Poisson regression analysis. Results Among 582 adults included in this analysis 14.9% were 65+ years old, 49.1% were women, 59.3% had uni- or bi-lateral lung involvement on chest computed tomography, 27.1% had any co-morbidity, 13.2% patients had lymphopenia, 4.1% had neutophilosis, 4.8% had low platelet count, 37.6% had d-dimer levels of >0.5 mcg/l. Overall mortality was 2.1% (12/582). After excluding mild infections, mortality among patients with moderate-to-critical disease was 3.0% (12/399), while among patients with severe-to-critical disease mortality was 12.7% (8/63). Baseline characteristics associated with increased risk of mortality in multivariate regression analysis included: age ≥65 years (RR: 10.38, 95% CI: 1.30-82.75), presence of any chronic co-morbidity (RR: 20.71, 95% CI: 1.58-270.99), lymphopenia (RR: 4.76, 95% CI: 1.52-14.93), neutrophilosis (RR: 7.22, 95% CI: 1.27-41.12), low platelet count (RR: 6.92, 95% CI: 1.18-40.54), elevated d-dimer (RR: 4.45, 95% CI: 1.48-13.35), elevated AST (RR: 6.33, 95% CI: 1.18-33.98). Conclusion In-hospital mortality during the first wave of pandemic in Georgia was low. We identified several risk factors (older age, co-morbidities and laboratory abnormalities) associated with poor outcome that should provide guidance for planning health sector response as pandemic continues to evolve.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.10.23.20218255
- https://www.medrxiv.org/content/medrxiv/early/2020/10/27/2020.10.23.20218255.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 15
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3097362364
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3097362364Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2020.10.23.20218255Digital Object Identifier
- Title
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Characteristics and outcomes of hospitalized adult COVID-19 patients in GeorgiaWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-10-27Full publication date if available
- Authors
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Tengiz Tsertsvadze, Marina Ezugbaia, Marina Endeladze, L Ratiani, Neli Javakhishvili, Lika Mumladze, Manana Khotchava, Maiko Janashia, Diana Zviadadze, Levan Gopodze, Alex Gokhelashvili, Revaz Metchurchtlishvili, Akaki Abutidze, Nikoloz ChkhartishviliList of authors in order
- Landing page
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https://doi.org/10.1101/2020.10.23.20218255Publisher landing page
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https://www.medrxiv.org/content/medrxiv/early/2020/10/27/2020.10.23.20218255.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.medrxiv.org/content/medrxiv/early/2020/10/27/2020.10.23.20218255.full.pdfDirect OA link when available
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Medicine, Poisson regression, Internal medicine, Retrospective cohort study, Multivariate analysis, Relative risk, Medical record, Pediatrics, Confidence interval, Population, Environmental healthTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2021: 1Per-year citation counts (last 5 years)
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15Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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