Characteristics and phenotypes of a COPD cohort in Uganda Article Swipe
Patricia Alupo
,
Levicatus Mugenyi
,
Winceslaus Katagira
,
K. Ittyavirah Alex
,
Nalunjogi Joanitah
,
Trishul Siddharthan
,
John R. Hurst
,
Bruce Kirenga
,
Rupert Jones
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.05.11.23289559
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.05.11.23289559
Introduction Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous condition with varied clinical and pathophysiologic characteristics. Although there is increasing evidence that COPD in low- and middle-income countries may have different clinical characteristics from that in high income countries, little is known about COPD phenotypes in these settings. We describe the clinical characteristics and risk factor profile of a COPD population in Uganda. Methods We cross sectionally analyzed the baseline clinical characteristics of 323 COPD patients aged 30 years and above who were attending two national referral outpatient facilities in Kampala, Uganda between July 2019 and March 2021. Logistic regression was used to determine factors associated with spirometric disease severity. Results The median age was 62 years; 51.1% females; 93.5% scored CAT >10; 63.8% mMRC >2; 71.8% had wheezing; 16.7% HIV positive; 20.4% had a history of pulmonary tuberculosis; 50% with blood eosinophilic count >3%, 51.7% had 3 or more exacerbations in the past year. Greater severity by GOLD stage was inversely related to age, (aOR=0.95, 95%CI=0.92, 0.97), and obesity compared to underweight (aOR=0.25, 95%CI=0.07, 0.82). Regarding clinical factors, more severe airflow obstruction was associated with SPO2<93% (aOR=3.79, 95%CI=2.05, 7.00), mMMRC≥2 (aOR=2.21, 95%CI=1.08, 4.53), and a history of severe exacerbations (aOR=2.64, 95%CI=1.32, 5.26). Conclusion COPD patients in this population had specific characteristics and risk factor profiles including HIV and TB meriting tailored preventative approaches. Further studies are needed to better understand the pathophysiological mechanisms at play and the therapeutic implications of these findings. Key messages What is already known on this topic. COPD is a heterogeneous condition with the greatest burden in LMICs yet there is limited understanding of disease characteristics in this setting. What this study adds A cohort of patients with COPD recruited in hospital clinics in Uganda showed a high burden of disease with frequent exacerbations – 86% were GOLD category D. The cohort had a high exposure to biomass smoke and only 38% were past or present smokers. How this study might affect research, practice, or policy There is need for more research into effective strategies to prevent and treat COPD in LMICs - it cannot be assumed that guidelines derived in high-income countries will apply.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.05.11.23289559
- https://www.medrxiv.org/content/medrxiv/early/2023/05/15/2023.05.11.23289559.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4376604166
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4376604166Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2023.05.11.23289559Digital Object Identifier
- Title
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Characteristics and phenotypes of a COPD cohort in UgandaWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-05-15Full publication date if available
- Authors
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Patricia Alupo, Levicatus Mugenyi, Winceslaus Katagira, K. Ittyavirah Alex, Nalunjogi Joanitah, Trishul Siddharthan, John R. Hurst, Bruce Kirenga, Rupert JonesList of authors in order
- Landing page
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https://doi.org/10.1101/2023.05.11.23289559Publisher landing page
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https://www.medrxiv.org/content/medrxiv/early/2023/05/15/2023.05.11.23289559.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.medrxiv.org/content/medrxiv/early/2023/05/15/2023.05.11.23289559.full.pdfDirect OA link when available
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Medicine, COPD, Underweight, Internal medicine, Population, Cohort, Referral, Outpatient clinic, Pediatrics, Obesity, Overweight, Environmental health, Family medicineTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2024: 1, 2023: 1Per-year citation counts (last 5 years)
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39Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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