Characteristics of the structural and functional state of the cardiovascular system in carriers of the HFE gene mutations Article Swipe
YOU?
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· 2025
· Open Access
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· DOI: https://doi.org/10.38109/2225-1685-2025-4-74-80
Objectives. To characterize the state of the cardiovascular system in patients carrying the HFE gene mutations in the Russian Federation. Materials and methods. An evaluation of 39 cases of HFE gene mutations confirmed by biochemical and genetic methods was carried out. Results. When analyzing the medical records of 39 patients with HFE gene mutations, changes in the structural and functional state of the cardiovascular system were detected in 20 (51.3%) patients. There was a history of arterial hypertension in 11 (28.21%) patients. Acute cerebrovascular accident was indicated in the anamnesis in 2 (5.13%) patients. A history of myocardial infarction was detected in 3 (7.69%) patients. Heart failure of non-ischemic genesis was diagnosed in 5 (12.82%) patients. In 14 (35.9%) patients in the form of atrioventricular block, left bundle branch block, right bundle branch block, intraventricular conduction disturbances, shortening of the PQ interval and prolongation of the QT interval, in 1 (2.56%) patient a paroxysmal form of atrial fibrillation was noted. Conclusion. Half patients with HFE gene mutations had various changes in the cardiovascular system. In this regard, patients with cardiac pathology of unclear etiology require screening for timely diagnosis of hemochromatosis and joint management of patients with confirmed hemochromatosis by hematologists, cardiologists and hepatologists to prevent cardiovascular complications.
Related Topics
- Type
- article
- Landing Page
- https://doi.org/10.38109/2225-1685-2025-4-74-80
- https://www.heartj.asia/jour/article/download/6560/6427
- OA Status
- diamond
- References
- 16
- OpenAlex ID
- https://openalex.org/W7106648171
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7106648171Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.38109/2225-1685-2025-4-74-80Digital Object Identifier
- Title
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Characteristics of the structural and functional state of the cardiovascular system in carriers of the HFE gene mutationsWork title
- Type
-
articleOpenAlex work type
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-26Full publication date if available
- Authors
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Mohamed Houcem E. Laouar, N. D. Musaev, I. S. Rodyukova, A. S. Grigorievskaya, S. N. Marshala, I.V. Semenyakin, E V ReznikList of authors in order
- Landing page
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https://doi.org/10.38109/2225-1685-2025-4-74-80Publisher landing page
- PDF URL
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https://www.heartj.asia/jour/article/download/6560/6427Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
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https://www.heartj.asia/jour/article/download/6560/6427Direct OA link when available
- Concepts
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Medicine, Hemochromatosis, Internal medicine, Cardiology, Atrial fibrillation, Hereditary hemochromatosis, Myocardial infarction, Gene mutation, Etiology, Heart failure, Electrical conduction system of the heart, Cardiomyopathy, Sudden cardiac death, Mutation, Anamnesis, Electrocardiography, Bioinformatics, Medical history, Troponin, Left bundle branch block, Pathology, QT interval, Family historyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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16Number of works referenced by this work
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| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-sa |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Eurasian heart journal |
| primary_location.landing_page_url | https://doi.org/10.38109/2225-1685-2025-4-74-80 |
| publication_date | 2025-11-26 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4225999476, https://openalex.org/W2801132106, https://openalex.org/W3116164355, https://openalex.org/W2005384029, https://openalex.org/W4211070211, https://openalex.org/W4327760309, https://openalex.org/W3182903151, https://openalex.org/W2910310746, https://openalex.org/W4404821190, https://openalex.org/W3202875508, https://openalex.org/W2964239140, https://openalex.org/W2730438192, https://openalex.org/W3159333219, https://openalex.org/W2115891976, https://openalex.org/W2129135378, https://openalex.org/W3212130041 |
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| abstract_inverted_index.(2.56%) | 150 |
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| abstract_inverted_index.(51.3%) | 69 |
| abstract_inverted_index.(7.69%) | 103 |
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