Characteristics, temporal trends and outcomes of intravenous thrombolysis in Chinese patients aged>80 years who had a stroke Article Swipe
Changsheng Li
,
Yingyu Jiang
,
Hongqiu Gu
,
Meng Wang
,
Zimo Chen
,
Xin Yang
,
Qi Zhou
,
Xia Meng
,
Chunjuan Wang
,
Zixiao Li
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1136/svn-2024-003427
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1136/svn-2024-003427
Background and purpose To date, no large cohort study has investigated the effects of intravenous thrombolysis (IVT) in Chinese patients aged over 80 years who had a stroke. This study aimed to assess the trends in the use of alteplase, the clinical characteristics and the outcomes of Chinese patients aged above 80 years who had an acute ischaemic stroke. Methods Data for this analysis were obtained from the China Stroke Center Alliance programme, a nationwide, multicentre, prospective registry encompassing 1751 hospitals across 31 provinces, covering the period from 1 January 2018 to 14 December 2022. The primary outcome was defined as a modified Rankin Scale (mRS) Score of 0–2 at discharge. Secondary outcomes included an mRS Score of 0–1 and independent ambulation on discharge. Safety outcomes assessed were in-hospital mortality and symptomatic intracranial haemorrhage (sICH). Results Out of 30 902 patients over 80 years old who qualified for thrombolysis, 8673 (median age (IQR), 84 (82–87) years) received alteplase treatment. Patients administered alteplase demonstrated improved short-term functional outcomes, such as an mRS Score of 0–2 (adjusted OR (aOR) 1.12, 95% CI, 1.06 to 1.18, p<0.001), an mRS Score of 0–1 (aOR 1.14, 95% CI, 1.08 to 1.19, p<0.001) and independent ambulation at discharge (aOR 1.14, 95% CI, 1.08 to 1.20, p<0.001). Moreover, no significant increase was observed in the risk of in-hospital mortality (aOR 1.12, 95% CI, 0.93 to 1.35; p=0.23). However, the risk of sICH was significantly higher among patients treated with alteplase (aOR 3.22, 95% CI, 2.77 to 3.75; p<0.001). Conclusions IVT with alteplase in elderly patients who had a stroke resulted in improved short-term functional outcomes without elevating the risk of in-hospital mortality. Nonetheless, this population remains at a higher risk of sICH.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/svn-2024-003427
- OA Status
- gold
- Cited By
- 2
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403945138
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4403945138Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1136/svn-2024-003427Digital Object Identifier
- Title
-
Characteristics, temporal trends and outcomes of intravenous thrombolysis in Chinese patients aged>80 years who had a strokeWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
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2024-10-31Full publication date if available
- Authors
-
Changsheng Li, Yingyu Jiang, Hongqiu Gu, Meng Wang, Zimo Chen, Xin Yang, Qi Zhou, Xia Meng, Chunjuan Wang, Zixiao LiList of authors in order
- Landing page
-
https://doi.org/10.1136/svn-2024-003427Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1136/svn-2024-003427Direct OA link when available
- Concepts
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Medicine, Thrombolysis, Modified Rankin Scale, Stroke (engine), Ischaemic stroke, Cohort, Internal medicine, Pediatrics, Emergency medicine, Ischemic stroke, Myocardial infarction, Ischemia, Mechanical engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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35Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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