Characterization of Calflagin, a Flagellar Calcium-Binding Protein from Trypanosoma congolense Article Swipe

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Trypanosoma Biology Monoclonal antibody Antigen Recombinant DNA Trypanosoma brucei Antibody Antigenic variation Trypanosoma cruzi Immunofluorescence Molecular biology Virology Biochemistry Parasite hosting Genetics Gene World Wide Web Computer science

Brett A. Eyford , Laura Kaufman , Orly Salama-Alber , Bianca C. Loveless , Matthew E. Pope , Robert D. Burke , Enock Matovu , Martin J. Boulanger , Terry W. Pearson ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.1371/journal.pntd.0004510 · OA: W2334792964

While calflagin is conserved among different species of African trypanosomes, our results show that T. congolense calflagin possesses unique epitopes that differentiate this protein from homologues in other trypanosome species. MAb Tc6/42.6.4 has clear utility as a laboratory tool for identifying T. congolense. T. congolense calflagin has potential as a serodiagnostic antigen and should be explored further for its utility in antigen-detection assays for diagnosis of cattle infections.