Characterization of CD41+ cells in the lymph node Article Swipe
Li Dai
,
Mayuko Uehara
,
Xiaofei Li
,
Brenna A. LaBarre
,
Naima Banouni
,
Takaharu Ichimura
,
Melissa M. Lee‐Sundlov
,
Vivek Kasinath
,
Jade A. Sullivan
,
Heyu Ni
,
Francesca Barone
,
Silvia Giannini
,
Baharak Bahmani
,
Peter T. Sage
,
Nikolaos A. Patsopoulos
,
George C. Tsokos
,
Jonathan S. Bromberg
,
Karin M. Hoffmeister
,
Liwei Jiang
,
Reza Abdi
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2022.801945
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2022.801945
Lymph nodes (LNs) are the critical sites of immunity, and the stromal cells of LNs are crucial to their function. Our understanding of the stromal compartment of the LN has deepened recently with the characterization of nontraditional stromal cells. CD41 (integrin αIIb) is known to be expressed by platelets and hematolymphoid cells. We identified two distinct populations of CD41 + Lyve1 + and CD41 + Lyve1 - cells in the LNs. CD41 + Lyve1 - cells appear in the LN mostly at the later stages of the lives of mice. We identified CD41 + cells in human LNs as well. We demonstrated that murine CD41 + cells express mesodermal markers, such as Sca-1, CD105 and CD29, but lack platelet markers. We did not observe the presence of platelets around the HEVs or within proximity to fibroblastic reticular cells of the LN. Examination of thoracic duct lymph fluid showed the presence of CD41 + Lyve1 - cells, suggesting that these cells recirculate throughout the body. FTY720 reduced their trafficking to lymph fluid, suggesting that their egress is controlled by the S1P1 pathway. CD41 + Lyve1 - cells of the LNs were sensitive to radiation, suggestive of their replicative nature. Single cell RNA sequencing data showed that the CD41 + cell population in naïve mouse LNs expressed largely stromal cell markers. Further studies are required to examine more deeply the role of CD41 + cells in the function of LNs.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2022.801945
- OA Status
- gold
- Cited By
- 1
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4290804022
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4290804022Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2022.801945Digital Object Identifier
- Title
-
Characterization of CD41+ cells in the lymph nodeWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-08-11Full publication date if available
- Authors
-
Li Dai, Mayuko Uehara, Xiaofei Li, Brenna A. LaBarre, Naima Banouni, Takaharu Ichimura, Melissa M. Lee‐Sundlov, Vivek Kasinath, Jade A. Sullivan, Heyu Ni, Francesca Barone, Silvia Giannini, Baharak Bahmani, Peter T. Sage, Nikolaos A. Patsopoulos, George C. Tsokos, Jonathan S. Bromberg, Karin M. Hoffmeister, Liwei Jiang, Reza AbdiList of authors in order
- Landing page
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https://doi.org/10.3389/fimmu.2022.801945Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fimmu.2022.801945Direct OA link when available
- Concepts
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Reticular cell, Lymph node stromal cell, Stromal cell, Lymph, Population, Cell biology, Chemistry, Immunophenotyping, Lymph node, Immunology, Biology, Pathology, Flow cytometry, Medicine, Cancer research, Environmental health, SpleenTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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56Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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