Characterization of Nocardithiocin Derivatives Produced by Amino Acid Substitution of Precursor Peptide notG Article Swipe
Kanae Sakai
,
Yasumasa Hara
,
Masami Ishibashi
,
Mai Sakai
,
Seiya Kawahara
,
Susumu Y. Imanishi
,
Ken‐ichi Harada
,
Yasutaka Hoshino
,
Hisayuki Komaki
,
Akira Mukai
,
Tohru Gonoi
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1007/s10989-019-09836-0
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1007/s10989-019-09836-0
Nocardithiocin is a thiopeptide compound produced by the pathogenic actinomycete Nocardia pseudobrasiliensis that displays activity against Gram-positive bacteria including drug-resistant Mycobacterium tuberculosis. However, the clinical use of nocardithiocin is hampered by light sensitivity and low water solubility. To improve these properties, the sixth amino acid of core peptide was substituted for other 19 amino acids by modifying the gene sequence of precursor peptide. Ten amino acids were successfully substituted to produce 1–3 novel compounds, of which six were the expected nocardithiocin derivatives. The compounds were tested for their stability, solubility, and antimicrobial activity. Of the 17 compounds produced, ten displayed antibiotic activity and two of them improved MIC value to bacteria. Furthermore, nocardithiocin and all derivatives were stable to the light. The substitution of amino acid sequence in precursor peptide could lead the successful production of nocardithiocin derivatives and alter its property. This report represents the first step of nocardithiocin utilization, and amino acid substitution technique can be used to create desirable nocardithiocin derivatives.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s10989-019-09836-0
- https://link.springer.com/content/pdf/10.1007/s10989-019-09836-0.pdf
- OA Status
- hybrid
- Cited By
- 6
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2923563292
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2923563292Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1007/s10989-019-09836-0Digital Object Identifier
- Title
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Characterization of Nocardithiocin Derivatives Produced by Amino Acid Substitution of Precursor Peptide notGWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-03-25Full publication date if available
- Authors
-
Kanae Sakai, Yasumasa Hara, Masami Ishibashi, Mai Sakai, Seiya Kawahara, Susumu Y. Imanishi, Ken‐ichi Harada, Yasutaka Hoshino, Hisayuki Komaki, Akira Mukai, Tohru GonoiList of authors in order
- Landing page
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https://doi.org/10.1007/s10989-019-09836-0Publisher landing page
- PDF URL
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https://link.springer.com/content/pdf/10.1007/s10989-019-09836-0.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
- OA URL
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https://link.springer.com/content/pdf/10.1007/s10989-019-09836-0.pdfDirect OA link when available
- Concepts
-
Peptide, Amino acid, Antimicrobial, Solubility, Chemistry, Peptide sequence, Bacteria, Amino acid substitution, Combinatorial chemistry, Stereochemistry, Biochemistry, Organic chemistry, Biology, Gene, Genetics, MutantTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
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2025: 1, 2024: 1, 2022: 2, 2020: 2Per-year citation counts (last 5 years)
- References (count)
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26Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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