Characterization of Oligometastatic Disease in a Real-World Nationwide Cohort of 3447 Patients With de Novo Metastatic Breast Cancer Article Swipe
Tessa G. Steenbruggen
,
Michael Schaapveld
,
Hugo M. Horlings
,
Joyce Sanders
,
Sander J Hogewoning
,
Esther H. Lips
,
Marie-Jeanne TFD Vrancken Peeters
,
Niels F.M. Kok
,
T. Wiersma
,
Laura J. Esserman
,
Laura van ’t Veer
,
Sabine C. Linn
,
Sabine Siesling
,
Gabe S. Sonke
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/jncics/pkab010
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/jncics/pkab010
Background Observational studies in metastatic breast cancer (MBC) show that long-term overall survival (OS) is associated with limited tumor burden, or oligo-MBC (OMBC). However, a uniform definition of OMBC is lacking. In this real-world nationwide cohort, we aimed to define the optimal OMBC threshold and factors associated with survival in patients with OMBC. Methods 3535 patients aged younger than 80 years at diagnosis of de novo MBC in the Netherlands between January 2000 and December 2007 were included. Detailed clinical, therapy, and outcome data were collected from medical records of a sample of the patients. Using inverse-sampling-probability weighting, the analysis cohort (n = 3447) was constructed. We assessed OS according to number of metastases at diagnosis to determine the optimal OMBC threshold. Next, we applied Cox regression models with inverse-sampling-probability weighting to study associations with OS and progression-free survival in OMBC. All statistical tests were 2-sided. Results Compared with more than 5 distant metastases, adjusted hazard ratios for OS (with 95% confidence interval [CI] based on robust standard errors) for 1, 2-3, and 4-5 metastases were 0.70 (95% CI = 0.52 to 0.96), 0.63 (95% CI = 0.45 to 0.89), and 0.91 (95% CI = 0.61 to 1.37), respectively. Ten-year OS estimates for patients with no more than 3 vs more than 3 metastases were 14.9% and 3.4% (P < .001). In multivariable analyses, premenopausal andperimenopausal status, absence of lung metastases, and local therapy of metastases (surgery and/or radiotherapy) added to systemic therapy were statistically significantly associated with better OS and progression-free survival in OMBC, independent of local therapy of the primary tumor. Conclusion OMBC defined as MBC limited to 1-3 metastases was associated with favorable OS. In OMBC, local therapy of metastases was associated with better OS, particularly if patients were premenopausal or perimenopausal without lung metastases.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/jncics/pkab010
- https://academic.oup.com/jncics/article-pdf/5/3/pkab010/37856131/pkab010.pdf
- OA Status
- gold
- Cited By
- 34
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3128619662
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3128619662Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/jncics/pkab010Digital Object Identifier
- Title
-
Characterization of Oligometastatic Disease in a Real-World Nationwide Cohort of 3447 Patients With de Novo Metastatic Breast CancerWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-01-24Full publication date if available
- Authors
-
Tessa G. Steenbruggen, Michael Schaapveld, Hugo M. Horlings, Joyce Sanders, Sander J Hogewoning, Esther H. Lips, Marie-Jeanne TFD Vrancken Peeters, Niels F.M. Kok, T. Wiersma, Laura J. Esserman, Laura van ’t Veer, Sabine C. Linn, Sabine Siesling, Gabe S. SonkeList of authors in order
- Landing page
-
https://doi.org/10.1093/jncics/pkab010Publisher landing page
- PDF URL
-
https://academic.oup.com/jncics/article-pdf/5/3/pkab010/37856131/pkab010.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/jncics/article-pdf/5/3/pkab010/37856131/pkab010.pdfDirect OA link when available
- Concepts
-
Medicine, Confidence interval, Hazard ratio, Cohort, Internal medicine, Proportional hazards model, Breast cancer, Metastatic breast cancer, Cancer registry, Oncology, Radiation therapy, Cancer, Inverse probability weighting, Propensity score matchingTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
34Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 8, 2023: 6, 2022: 12, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
53Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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