Characterization of Somatostatin Receptor 2 Gene Expression and Immune Landscape in Sinonasal Malignancies Article Swipe
Elisabetta Xue
,
Dara Bracken‐Clarke
,
Harris Benjamin Krause
,
Tolulope Adeyelu
,
Mark G. Evans
,
Dilara Akbulut
,
Martha Quezado
,
Nishant Gandhi
,
Alex Farrell
,
Heloisa P. Soares
,
Emil Lou
,
Minh Phan
,
Rusha Patel
,
Ari M. Vanderwalde
,
Andrew Elliott
,
Conor Steuer
,
Nabil F. Saba
,
Daniel Lubin
,
Nyall R. London
,
James L. Gulley
,
Charalampos S. Floudas
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cancers16233931
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cancers16233931
Olfactory neuroblastoma (ONB), sinonasal undifferentiated carcinoma (SNUC), and sinonasal neuroendocrine carcinoma (SNEC) are rare malignancies arising from the sinonasal tract with limited therapeutic options. The expression of the somatostatin receptor 2 gene (SSTR2), which is expressed in other neuroendocrine neoplasms and is therapeutically actionable, has been reported in these tumors. Here, we analyzed SSTR2 gene expression and its associations with genomic features, established biomarkers predicting of immune response, and the tumor immune microenvironment in a cohort of ONB, SNUC, and SNEC tumor samples (26, 13, and 8 samples, respectively) from a real-world database. SSTR2 gene expression was high in neural-type ONB and low in basal-type ONB and in most of the SNUC and SNEC cases; there was no difference in expression between primary and metastatic tumors. The T cell-inflamed (TCI) score analysis classified 38.5% of SNUC cases as T cell-inflamed compared to only 3.9% of ONB and 0% of SNEC cases; 26.9% of ONB cases were classified as intermediate TCI; and SNEC had the lowest relative immune cell infiltration by deconvolution. In high SSTR2-expressing ONB, there was a higher proportion of infiltrating of Natural Killer cells and dendritic cells by deconvolution. Additionally, high SSTR2-expressing ONB was enriched for proliferation pathways, including E2F and Myc targets and G2M checkpoints. In conclusion, our findings delineate significant differences between these three types of sinonasal malignancies that were examined. In ONB, relative to SNUC and SNEC, the SSTR2 expression profile, combined with its immune profiles, indicates potential novel therapeutic strategies and combinations for this unmet clinical need. Conversely, the inflammatory microenvironment of SNUC may be targetable using immuno-oncologic therapies.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers16233931
- OA Status
- gold
- Cited By
- 1
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404695604
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404695604Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cancers16233931Digital Object Identifier
- Title
-
Characterization of Somatostatin Receptor 2 Gene Expression and Immune Landscape in Sinonasal MalignanciesWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-11-24Full publication date if available
- Authors
-
Elisabetta Xue, Dara Bracken‐Clarke, Harris Benjamin Krause, Tolulope Adeyelu, Mark G. Evans, Dilara Akbulut, Martha Quezado, Nishant Gandhi, Alex Farrell, Heloisa P. Soares, Emil Lou, Minh Phan, Rusha Patel, Ari M. Vanderwalde, Andrew Elliott, Conor Steuer, Nabil F. Saba, Daniel Lubin, Nyall R. London, James L. Gulley, Charalampos S. FloudasList of authors in order
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https://doi.org/10.3390/cancers16233931Publisher landing page
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3390/cancers16233931Direct OA link when available
- Concepts
-
Somatostatin receptor, Immune system, Gene, Somatostatin, Cancer research, Gene expression, Biology, Receptor, Medicine, Computational biology, Bioinformatics, Genetics, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
-
51Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| primary_location.landing_page_url | https://doi.org/10.3390/cancers16233931 |
| publication_date | 2024-11-24 |
| publication_year | 2024 |
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