Characterization of the “gut microbiota-immunity axis” and microbial lipid metabolites in atrophic and potential celiac disease Article Swipe
Federica Ricci
,
Edda Russo
,
Daniela Renzi
,
Simone Baldi
,
Giulia Nannini
,
G Lami
,
Marta Menicatti
,
Marco Pallecchi
,
Gianluca Bartolucci
,
Elena Niccolai
,
Matteo Cerboneschi
,
Serena Smeazzetto
,
Matteo Ramazzotti
,
Amedeo Amedei
,
Antonino Calabrò
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2022.886008
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2022.886008
Introduction Potential celiac disease (pCD) is characterized by genetic predisposition, positive anti-endomysial and anti-tissue transglutaminase antibodies, but a normal or almost normal jejunal mucosa (e.g., minor histological abnormalities without villous atrophy). To gain further insights into basic mechanisms involved in the development of intestinal villous atrophy, we evaluated and compared the microbial, lipid, and immunological signatures of pCD and atrophic CD (aCD). Materials and methods This study included 17 aCD patients, 10 pCD patients, and 12 healthy controls (HC). Serum samples from all participants were collected to analyze free fatty acids (FFAs). Duodenal mucosa samples of aCD and pCD patients were taken to evaluate histology, tissue microbiota composition, and mucosal immune response. Results We found no significant differences in the mucosa-associated microbiota composition of pCD and aCD patients. On the other hand, in pCD patients, the overall abundance of serum FFAs showed relevant and significant differences in comparison with aCD patients and HC. In detail, compared to HC, pCD patients displayed higher levels of propionic, butyric, valeric, 2-ethylhexanoic, tetradecanoic, hexadecanoic, and octadecanoic acids. Instead, aCD patients showed increased levels of propionic, isohexanoic, and 2-ethylhexanoic acids, and a lower abundance of isovaleric and 2-methylbutyricacids when compared to HC. In addition, compared to aCD patients, pCD patients showed a higher abundance of isobutyric and octadecanoic acid. Finally, the immunological analysis of duodenal biopsy revealed a lower percentage of CD4 + T lymphocytes in pCD infiltrate compared to that observed in aCD patients. The functional characterization of T cells documented a pro-inflammatory immune response in both aCD and pCD patients, but the pCD patients showed a higher percentage of Th0/Th17 and a lower percentage of Th1/Th17. Conclusion The results of the present study show, for the first time, that the duodenal microbiota of patients with pCD does not differ substantially from that of aCD; however, serum FFAs and local T cells displayed a distinctive profile between pCD, aCD, and HC. In conclusion, our result may help to shed new light on the “gut microbiota-immunity axis,” lipid metabolites, and duodenal immune response in overt CD and pCD patients, opening new paradigms in understanding the pathogenesis behind CD progression.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmicb.2022.886008
- OA Status
- gold
- Cited By
- 7
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4298144101
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4298144101Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fmicb.2022.886008Digital Object Identifier
- Title
-
Characterization of the “gut microbiota-immunity axis” and microbial lipid metabolites in atrophic and potential celiac diseaseWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-09-30Full publication date if available
- Authors
-
Federica Ricci, Edda Russo, Daniela Renzi, Simone Baldi, Giulia Nannini, G Lami, Marta Menicatti, Marco Pallecchi, Gianluca Bartolucci, Elena Niccolai, Matteo Cerboneschi, Serena Smeazzetto, Matteo Ramazzotti, Amedeo Amedei, Antonino CalabròList of authors in order
- Landing page
-
https://doi.org/10.3389/fmicb.2022.886008Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fmicb.2022.886008Direct OA link when available
- Concepts
-
Immune system, Atrophy, Tissue transglutaminase, Intestinal mucosa, Dysbiosis, Immunology, Histology, Gut flora, Biology, Internal medicine, Villous atrophy, Antibody, Gastroenterology, Medicine, Pathology, Disease, Coeliac disease, Enzyme, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 3, 2023: 3Per-year citation counts (last 5 years)
- References (count)
-
64Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.other | 130 |
| abstract_inverted_index.overt | 339 |
| abstract_inverted_index.serum | 139, 302 |
| abstract_inverted_index.show, | 280 |
| abstract_inverted_index.study | 66, 279 |
| abstract_inverted_index.taken | 101 |
| abstract_inverted_index.time, | 284 |
| abstract_inverted_index.(aCD). | 61 |
| abstract_inverted_index.(e.g., | 24 |
| abstract_inverted_index.acids, | 184 |
| abstract_inverted_index.acids. | 172 |
| abstract_inverted_index.almost | 20 |
| abstract_inverted_index.behind | 351 |
| abstract_inverted_index.biopsy | 220 |
| abstract_inverted_index.celiac | 2 |
| abstract_inverted_index.differ | 295 |
| abstract_inverted_index.higher | 161, 207, 263 |
| abstract_inverted_index.immune | 110, 249, 336 |
| abstract_inverted_index.levels | 162, 178 |
| abstract_inverted_index.lipid, | 52 |
| abstract_inverted_index.mucosa | 23, 93 |
| abstract_inverted_index.normal | 18, 21 |
| abstract_inverted_index.result | 320 |
| abstract_inverted_index.showed | 141, 176, 205, 261 |
| abstract_inverted_index.tissue | 105 |
| abstract_inverted_index.“gut | 329 |
| abstract_inverted_index.(FFAs). | 91 |
| abstract_inverted_index.Results | 112 |
| abstract_inverted_index.analyze | 87 |
| abstract_inverted_index.between | 312 |
| abstract_inverted_index.detail, | 154 |
| abstract_inverted_index.disease | 3 |
| abstract_inverted_index.further | 33 |
| abstract_inverted_index.genetic | 8 |
| abstract_inverted_index.healthy | 76 |
| abstract_inverted_index.jejunal | 22 |
| abstract_inverted_index.methods | 64 |
| abstract_inverted_index.mucosal | 109 |
| abstract_inverted_index.opening | 344 |
| abstract_inverted_index.overall | 136 |
| abstract_inverted_index.present | 278 |
| abstract_inverted_index.profile | 311 |
| abstract_inverted_index.results | 275 |
| abstract_inverted_index.samples | 80, 94 |
| abstract_inverted_index.villous | 29, 44 |
| abstract_inverted_index.without | 28 |
| abstract_inverted_index.Duodenal | 92 |
| abstract_inverted_index.Finally, | 214 |
| abstract_inverted_index.Instead, | 173 |
| abstract_inverted_index.Th0/Th17 | 266 |
| abstract_inverted_index.analysis | 217 |
| abstract_inverted_index.atrophic | 59 |
| abstract_inverted_index.atrophy, | 45 |
| abstract_inverted_index.axis,” | 331 |
| abstract_inverted_index.butyric, | 165 |
| abstract_inverted_index.compared | 49, 155, 194, 199, 233 |
| abstract_inverted_index.controls | 77 |
| abstract_inverted_index.duodenal | 219, 287, 335 |
| abstract_inverted_index.evaluate | 103 |
| abstract_inverted_index.however, | 301 |
| abstract_inverted_index.included | 67 |
| abstract_inverted_index.insights | 34 |
| abstract_inverted_index.involved | 38 |
| abstract_inverted_index.observed | 236 |
| abstract_inverted_index.patients | 99, 150, 159, 175, 204, 260, 290 |
| abstract_inverted_index.positive | 10 |
| abstract_inverted_index.relevant | 142 |
| abstract_inverted_index.response | 250, 337 |
| abstract_inverted_index.revealed | 221 |
| abstract_inverted_index.valeric, | 166 |
| abstract_inverted_index.Materials | 62 |
| abstract_inverted_index.Potential | 1 |
| abstract_inverted_index.Th1/Th17. | 272 |
| abstract_inverted_index.abundance | 137, 188, 208 |
| abstract_inverted_index.addition, | 198 |
| abstract_inverted_index.atrophy). | 30 |
| abstract_inverted_index.collected | 85 |
| abstract_inverted_index.displayed | 160, 308 |
| abstract_inverted_index.evaluated | 47 |
| abstract_inverted_index.increased | 177 |
| abstract_inverted_index.paradigms | 346 |
| abstract_inverted_index.patients, | 70, 73, 134, 202, 256, 343 |
| abstract_inverted_index.patients. | 127, 239 |
| abstract_inverted_index.response. | 111 |
| abstract_inverted_index.Conclusion | 273 |
| abstract_inverted_index.comparison | 147 |
| abstract_inverted_index.documented | 246 |
| abstract_inverted_index.functional | 241 |
| abstract_inverted_index.histology, | 104 |
| abstract_inverted_index.infiltrate | 232 |
| abstract_inverted_index.intestinal | 43 |
| abstract_inverted_index.isobutyric | 210 |
| abstract_inverted_index.isovaleric | 190 |
| abstract_inverted_index.mechanisms | 37 |
| abstract_inverted_index.microbial, | 51 |
| abstract_inverted_index.microbiota | 106, 121, 288 |
| abstract_inverted_index.percentage | 224, 264, 270 |
| abstract_inverted_index.propionic, | 164, 180 |
| abstract_inverted_index.signatures | 55 |
| abstract_inverted_index.anti-tissue | 13 |
| abstract_inverted_index.antibodies, | 15 |
| abstract_inverted_index.composition | 122 |
| abstract_inverted_index.conclusion, | 318 |
| abstract_inverted_index.development | 41 |
| abstract_inverted_index.differences | 117, 145 |
| abstract_inverted_index.distinctive | 310 |
| abstract_inverted_index.lymphocytes | 229 |
| abstract_inverted_index.significant | 116, 144 |
| abstract_inverted_index.Introduction | 0 |
| abstract_inverted_index.composition, | 107 |
| abstract_inverted_index.histological | 26 |
| abstract_inverted_index.isohexanoic, | 181 |
| abstract_inverted_index.metabolites, | 333 |
| abstract_inverted_index.octadecanoic | 171, 212 |
| abstract_inverted_index.participants | 83 |
| abstract_inverted_index.pathogenesis | 350 |
| abstract_inverted_index.progression. | 353 |
| abstract_inverted_index.abnormalities | 27 |
| abstract_inverted_index.characterized | 6 |
| abstract_inverted_index.hexadecanoic, | 169 |
| abstract_inverted_index.immunological | 54, 216 |
| abstract_inverted_index.substantially | 296 |
| abstract_inverted_index.understanding | 348 |
| abstract_inverted_index.tetradecanoic, | 168 |
| abstract_inverted_index.2-ethylhexanoic | 183 |
| abstract_inverted_index.anti-endomysial | 11 |
| abstract_inverted_index.predisposition, | 9 |
| abstract_inverted_index.2-ethylhexanoic, | 167 |
| abstract_inverted_index.characterization | 242 |
| abstract_inverted_index.pro-inflammatory | 248 |
| abstract_inverted_index.transglutaminase | 14 |
| abstract_inverted_index.mucosa-associated | 120 |
| abstract_inverted_index.microbiota-immunity | 330 |
| abstract_inverted_index.2-methylbutyricacids | 192 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5082342925 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| corresponding_institution_ids | https://openalex.org/I45084792 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6899999976158142 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.78339893 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |