Characterization of the Tumor Microenvironment in Jaw Osteosarcomas, towards Prognostic Markers and New Therapeutic Targets Article Swipe
Hélios Bertin
,
Sophie Peries
,
Jérôme Amiaud
,
Nathalie Van Acker
,
Bastien Perrot
,
Corinne Bouvier
,
Sébastien Aubert
,
Béatrice Marie
,
Frédérique Larousserie
,
Gonzague de Pinieux
,
Vincent Crenn
,
Françoise Rédiní
,
Anne Gomez‐Brouchet
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/cancers15041004
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/cancers15041004
Background—The purpose of this study was to investigate the bone resorption, as well as the vascular and immune microenvironment, of jaw osteosarcomas (JO) and to correlate these features with patient clinical outcomes. Methods—We studied 50 JO biopsy samples by immunohistochemical analysis of tissue microarrays (TMAs). We investigated the bone remodeling markers RANK/RANKL/OPG, the endothelial glycoprotein CD146, and biomarkers of the immune environment (CD163 and CD68 of macrophages, CD4+ and CD8+ of tumor-infiltrating lymphocytes (TILs), and an immune checkpoint PD-1/PD-L1). The biomarkers were analyzed for their influence on progression (recurrence and metastasis), overall survival (OS), and disease-free survival (DFS). Results—A strong and significant correlation has been found between CD163 staining and lower OS and DFS. The level of CD4+ and CD8+ staining was low and non-significantly associated with survival outcomes. High levels of RANK and RANKL were found in the tumor samples and correlated with lower DFS. Conclusion—Our findings suggest that CD163+ TAMs represent markers of poor prognosis in JO. Targeting TAMs could represent a valuable therapeutic strategy in JO.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers15041004
- https://www.mdpi.com/2072-6694/15/4/1004/pdf?version=1675645094
- OA Status
- gold
- Cited By
- 7
- References
- 67
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4319319969
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4319319969Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cancers15041004Digital Object Identifier
- Title
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Characterization of the Tumor Microenvironment in Jaw Osteosarcomas, towards Prognostic Markers and New Therapeutic TargetsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-02-04Full publication date if available
- Authors
-
Hélios Bertin, Sophie Peries, Jérôme Amiaud, Nathalie Van Acker, Bastien Perrot, Corinne Bouvier, Sébastien Aubert, Béatrice Marie, Frédérique Larousserie, Gonzague de Pinieux, Vincent Crenn, Françoise Rédiní, Anne Gomez‐BrouchetList of authors in order
- Landing page
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https://doi.org/10.3390/cancers15041004Publisher landing page
- PDF URL
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https://www.mdpi.com/2072-6694/15/4/1004/pdf?version=1675645094Direct link to full text PDF
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-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2072-6694/15/4/1004/pdf?version=1675645094Direct OA link when available
- Concepts
-
Tumor microenvironment, Cancer research, Medicine, Tumor cellsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 5Per-year citation counts (last 5 years)
- References (count)
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67Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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