Characterizing 24-Hour Skeletal Muscle Gene Expression Alongside Metabolic and Endocrine Responses Under Diurnal Conditions Article Swipe
Harry Smith
,
Iain Templeman
,
Max E. Davis
,
Tommy Slater
,
David J. Clayton
,
Ian Varley
,
Lewis J. James
,
Benita Middleton
,
Jonathan D. Johnston
,
Leonidas G. Karagounis
,
Kostas Tsintzas
,
Dylan Thompson
,
Javier T. Gonzalez
,
Jean‐Philippe Walhin
,
James A. Betts
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1210/clinem/dgae350
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1210/clinem/dgae350
Context Skeletal muscle plays a central role in the storage, synthesis, and breakdown of nutrients, yet little research has explored temporal responses of this human tissue, especially with concurrent measures of systemic biomarkers of metabolism. Objective To characterize temporal profiles in skeletal muscle expression of genes involved in carbohydrate metabolism, lipid metabolism, circadian clocks, and autophagy and descriptively relate them to systemic metabolites and hormones during a controlled laboratory protocol. Methods Ten healthy adults (9M/1F, [mean ± SD] age 30 ± 10 years; BMI 24.1 ± 2.7 kg·m−2) rested in the laboratory for 37 hours with all data collected during the final 24 hours (08:00–08:00 hours). Participants ingested hourly isocaloric liquid meal replacements alongside appetite assessments during waking before a sleep opportunity from 22:00 to 07:00 hours. Blood samples were collected hourly for endocrine and metabolite analyses, with muscle biopsies occurring every 4 hours from 12:00 to 08:00 hours the following day to quantify gene expression. Results Plasma insulin displayed diurnal rhythmicity peaking at 18:04 hours. Expression of skeletal muscle genes involved in carbohydrate metabolism (Name, Acrophase [hours]: GLUT4, 14:40; PPARGC1A, 16:13; HK2, 18:24) and lipid metabolism (FABP3, 12:37; PDK4, 05:30; CPT1B, 12:58) displayed 24-hour rhythmicity that reflected the temporal rhythm of insulin. Equally, circulating glucose (00:19 hours), nonesterified fatty acids (04:56), glycerol (04:32), triglyceride (23:14), urea (00:46), C-terminal telopeptide (05:07), and cortisol (22:50) concentrations also all displayed diurnal rhythmicity. Conclusion Diurnal rhythms were present in human skeletal muscle gene expression as well systemic metabolites and hormones under controlled diurnal conditions. The temporal patterns of genes relating to carbohydrate and lipid metabolism alongside circulating insulin are consistent with diurnal rhythms being driven in part by the diurnal influence of cyclic feeding and fasting.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1210/clinem/dgae350
- https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgae350/57837294/dgae350.pdf
- OA Status
- hybrid
- Cited By
- 5
- References
- 145
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4398246714
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4398246714Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1210/clinem/dgae350Digital Object Identifier
- Title
-
Characterizing 24-Hour Skeletal Muscle Gene Expression Alongside Metabolic and Endocrine Responses Under Diurnal ConditionsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-22Full publication date if available
- Authors
-
Harry Smith, Iain Templeman, Max E. Davis, Tommy Slater, David J. Clayton, Ian Varley, Lewis J. James, Benita Middleton, Jonathan D. Johnston, Leonidas G. Karagounis, Kostas Tsintzas, Dylan Thompson, Javier T. Gonzalez, Jean‐Philippe Walhin, James A. BettsList of authors in order
- Landing page
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https://doi.org/10.1210/clinem/dgae350Publisher landing page
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https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgae350/57837294/dgae350.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgae350/57837294/dgae350.pdfDirect OA link when available
- Concepts
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Skeletal muscle, Endocrine system, Endocrinology, Gene expression, Internal medicine, Biology, Gene, Genetics, Medicine, HormoneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
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2025: 3, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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145Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| publication_date | 2024-05-22 |
| publication_year | 2024 |
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