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Characterizing the human hippocampus in aging and Alzheimer’s disease using a computational atlas derived from ex vivo MRI and histology
March 2018 • Daniel Adler, Laura E.M. Wisse, Ranjit Ittyerah, John Pluta, Song‐Lin Ding, Long Xie, Jiancong Wang, Salmon Kadivar, John Robinson, Theresa Schuck, J…
Significance There has been increasing interest in hippocampal subfield morphometry in aging and disease using in vivo MRI. However, research on in vivo morphometry is hampered by the lack of a definitive reference model describing regional effects of aging and disease pathology on the hippocampus. To address this limitation, we built a 3D probabilistic atlas of the hippocampus combining postmortem MRI with histology, allowing us to investigate Alzheimer’s disease (AD)-related effects on hippocampal subfield morph…