Charge site manipulation to enhance top‐down fragmentation efficiency Article Swipe
Tanja Habeck
,
Edvaldo Vasconcelos Soares Maciel
,
Kevin Kretschmer
,
Frederik Lermyte
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/pmic.202300082
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/pmic.202300082
In recent years, top‐down mass spectrometry has become a widely used approach to study proteoforms; however, improving sequence coverage remains an important goal. Here, two different proteins, α‐synuclein and bovine carbonic anhydrase, were subjected to top‐down collision‐induced dissociation (CID) after electrospray ionisation. Two high‐boiling solvents, DMSO and propylene carbonate, were added to the protein solution in low concentration (2%) and the effects on the top‐down fragmentation patterns of the proteins were systematically investigated. Each sample was measured in triplicate, which revealed highly reproducible differences in the top‐down CID fragmentation patterns in the presence of a solution additive, even if the same precursor charge state was isolated in the quadrupole of the instrument. Further investigation supports the solution condition‐dependent selective formation of different protonation site isomers as the underlying cause of these differences. Higher sequence coverage was often observed in the presence of additives, and the benefits of this approach became even more evident when datasets from different solution conditions were combined, as increases up to 35% in cleavage coverage were obtained. Overall, this approach therefore represents a promising opportunity to increase top‐down fragmentation efficiency.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/pmic.202300082
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmic.202300082
- OA Status
- hybrid
- Cited By
- 4
- References
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- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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https://doi.org/10.1002/pmic.202300082Digital Object Identifier
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Charge site manipulation to enhance top‐down fragmentation efficiencyWork title
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articleOpenAlex work type
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enPrimary language
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2023Year of publication
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2023-04-12Full publication date if available
- Authors
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Tanja Habeck, Edvaldo Vasconcelos Soares Maciel, Kevin Kretschmer, Frederik LermyteList of authors in order
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https://doi.org/10.1002/pmic.202300082Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmic.202300082Direct OA link when available
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Fragmentation (computing), Nanotechnology, Chemistry, Biology, Materials science, EcologyTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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