Implicit solvent models are widely used because they are advantageous to speed up simulations by drastically decreasing the number of solvent degrees of freedom, which allows one to achieve long simulation time scales for large system sizes. CHARMM-GUI, a web-based platform, has been developed to support the setup of complex multicomponent molecular systems and prepare input files. This study describes an <i>Implicit Solvent Modeler</i> (ISM) in CHARMM-GUI for various generalized Born (GB) implicit solvent simulat…