Charting a path for prioritization of novel agents for clinical trials in osteosarcoma: A report from the Children's Oncology Group New Agents for Osteosarcoma Task Force Article Swipe
Sarah Burkhead Whittle
,
Katharine Offer
,
Ryan D. Roberts
,
Amy K. LeBlanc
,
Cheryl A. London
,
Robbie G. Majzner
,
Alex Y. Huang
,
Peter J. Houghton
,
Esteban Cordero
,
Patrick J. Grohar
,
Michael S. Isakoff
,
Michael W. Bishop
,
Elizabeth Stewart
,
Emily K. Slotkin
,
Emily Greengard
,
Scott C. Borinstein
,
Fariba Navid
,
Richard Görlick
,
Katherine A. Janeway
,
Damon R. Reed
,
Pooja Hingorani
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1002/pbc.29188
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1002/pbc.29188
Osteosarcoma is the most common bone tumor in children and young adults. Metastatic and relapsed disease confer poor prognosis, and there have been no improvements in outcomes for several decades. The disease's biological complexity, lack of drugs developed specifically for osteosarcoma, imperfect preclinical models, and limits of existing clinical trial designs have contributed to lack of progress. The Children's Oncology Group Bone Tumor Committee established the New Agents for Osteosarcoma Task Force to identify and prioritize agents for inclusion in clinical trials. The group identified multitargeted tyrosine kinase inhibitors, immunotherapies targeting B7‐H3, CD47‐SIRPα inhibitors, telaglenastat, and epigenetic modifiers as the top agents of interest. Only multitargeted tyrosine kinase inhibitors met all criteria for frontline evaluation and have already been incorporated into an upcoming phase III study concept. The task force will continue to reassess identified agents of interest as new data become available and evaluate novel agents using this method.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/pbc.29188
- OA Status
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- Cited By
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- References
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- Related Works
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3169589126Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/pbc.29188Digital Object Identifier
- Title
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Charting a path for prioritization of novel agents for clinical trials in osteosarcoma: A report from the Children's Oncology Group New Agents for Osteosarcoma Task ForceWork title
- Type
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articleOpenAlex work type
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-06-16Full publication date if available
- Authors
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Sarah Burkhead Whittle, Katharine Offer, Ryan D. Roberts, Amy K. LeBlanc, Cheryl A. London, Robbie G. Majzner, Alex Y. Huang, Peter J. Houghton, Esteban Cordero, Patrick J. Grohar, Michael S. Isakoff, Michael W. Bishop, Elizabeth Stewart, Emily K. Slotkin, Emily Greengard, Scott C. Borinstein, Fariba Navid, Richard Görlick, Katherine A. Janeway, Damon R. Reed, Pooja HingoraniList of authors in order
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https://doi.org/10.1002/pbc.29188Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/8316376Direct OA link when available
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Medicine, Osteosarcoma, Clinical trial, Oncology, Disease, Internal medicine, Cancer researchTop concepts (fields/topics) attached by OpenAlex
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14Total citation count in OpenAlex
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2025: 2, 2024: 5, 2023: 4, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
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76Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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