Checkpoint CD47 expression in classical Hodgkin lymphoma
Article Swipe
Alex Reza Gholiha
,
Peter Hollander
,
Liza Löf
,
Ingrid Glimelius
,
Gustaf Hedström
,
Daniel Molin
,
Henrik Hjalgrim
,
Karin E. Smedby
,
Jamileh Hashemi
,
Rose‐Marie Amini
,
Gunilla Enblad
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1111/bjh.18137
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1111/bjh.18137
Summary The glycoprotein CD47 regulates antiphagocytic activity via signal regulatory protein alpha (SIRPa). This study investigated CD47 expression on Hodgkin and Reed–Sternberg (HRS) cells in the classical Hodgkin lymphoma (cHL) tumour microenvironment and its correlation with prognosis, programmed‐death (PD) immune markers, and SIRPa + leukocytes. We conducted immunohistochemistry with CD47 and SIRPa antibodies on diagnostic biopsies (tissue microarrays) from cHL patients from two cohorts ( n = 178). In cohort I ( n = 136) patients with high expression of CD47 on HRS cells ( n = 48) had a significantly inferior event‐free survival [hazard ratio (HR) = 5.57; 95% confidence interval (CI), 2.78–11.20; p < 0 .001] and overall survival (OS) (HR = 8.54; 95% CI, 3.19–22.90; p < 0.001) compared with patients with low expression ( n = 88). The survival results remained statistically significant in multivariable Cox regression adjusted for known prognostic factors. In cohort II ( n = 42) high HRS cell CD47 expression also carried shorter event‐free survival (EFS) (HR = 5.96; 95% CI, 1.20–29.59; p = 0.029) and OS (HR = 5.61; 95% CI, 0.58–54.15; p = 0.136), although it did not retain statistical significance in the multivariable analysis. Further, high CD47 expression did not correlate with SIRPa + leukocytes or PD‐1, PD‐L1 and PD‐L2 expression. This study provides a deeper understanding of the role of CD47 in cHL during an era of emerging CD47 therapies.
Related Topics
Concepts
Lymphoma
CD47
Classical Hodgkin lymphoma
Hodgkin lymphoma
Cancer research
Medicine
Virology
Immunology
Phagocytosis
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/bjh.18137
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.18137
- OA Status
- hybrid
- Cited By
- 19
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4220710353
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4220710353Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/bjh.18137Digital Object Identifier
- Title
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Checkpoint
CD47 expression in classical Hodgkin lymphomaWork title - Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-03-17Full publication date if available
- Authors
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Alex Reza Gholiha, Peter Hollander, Liza Löf, Ingrid Glimelius, Gustaf Hedström, Daniel Molin, Henrik Hjalgrim, Karin E. Smedby, Jamileh Hashemi, Rose‐Marie Amini, Gunilla EnbladList of authors in order
- Landing page
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https://doi.org/10.1111/bjh.18137Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.18137Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.18137Direct OA link when available
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Lymphoma, CD47, Classical Hodgkin lymphoma, Hodgkin lymphoma, Cancer research, Medicine, Virology, Immunology, PhagocytosisTop concepts (fields/topics) attached by OpenAlex
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19Total citation count in OpenAlex
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2025: 3, 2024: 5, 2023: 6, 2022: 5Per-year citation counts (last 5 years)
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49Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5078312452 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I123387679 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.4699999988079071 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.84424844 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |