Chemical composition, acute and sub-acute toxicity of Satureja khuzestanica essential oil in mice Article Swipe
Shirzad Fallahi
,
Maryam Beyranvand
,
Hossein Mahmoudvand
,
Hassan Nayebzadeh
,
Farnaz Kheirandish
,
Sareh Jahanbakhsh
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.12991/marupj.318614
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.12991/marupj.318614
Bitkilerin çeşitli hastalıkların tedavisi için ilaç geliştirmeamacıyla kullanılan önemli kaynaklar olduğu bilinmektedirancak bitkisel ilaçların tedavi amacıyla kullanılabilmesi için yanetki profillerinin belirlenmesi gereklidir. Bu çalışmada, Saturejakhuzestanica uçucu yağının (SKEO) kimyasal bileşiminintespiti ve bir fare modelinde akut ve sub-akut toksisitesiningösterilmesi amaçlanmıştır. Satureja khuzestanica örnekleriİran’ın batısındaki Lorestan bölgesinin kırsal alanlarındantoplanmıştır. SKEO’nun kimyasal bileşimi gaz kromatografisi/kütle spektrometrisi (GC/MS) yöntemiyle belirlenmiştir.Akut toksisitesinin belirlenmesi amacıyla SKEO, 0.5, 1, 2 and4 ml/kg dozlarda 6’şar fareden oluşan 4 gruba intraperitonealenjeksiyonla uygulanmıştır. Uygulamadan 24 saat sonra ölenfareler sayılmıştır. SKEO’nun sub-akut toksik etkilerininbelirlenmesi için 14 gün boyunca oral yoldan 0.2, 0.4 and 0.8ml/kg dozlarda SKEO uygulanan farelerin biyokimyasal vehemotolojik parametreleri incelenmiştir.GC-MS yöntemiyle yapılan çalışmada SKEO içeriğindebulunan 23 bileşik tespit edilmiş ve bu bileşikler içerisinde enyüksek miktarda bulunan türevin %64.4 oranıyla karvakrololduğu görülmüştür. İntraperitoneal enjeksiyon yoluylauygulanan SKEO’nun LD50 değeri 1.79 ml/kg, maksimumöldürücü olmayan dozu ise 1.13 ml/kg olarak bildirilmiştir.SKEO’nun; 0.2 and 0.4 ml/kg dozlarda uygulandığı gruplardaölüm tespit edilmezken bileşiğe 0.8 ml/kg dozda maruz falanfarelerden sadece biri ölmüştür (%12.5). Oral yoldan 0.2, 0.4and 0.8 ml/kg dozlarda SKEO uygulanan farelerin biyokimyasalve hemotolojik parametreleri kontrol grubuna ait değerlerlekarşılaştırıldığında anlamlı bir farklılık tespit edilmemiştir(P>0.05). Bu çalışma sonucunda elde edilen veriler; SKEO’nun,farelerin karaciğer, böbrek dokuları ve kan parametreleriüzerinde belirgin bir toksistesi olmadığını göstermiştir. Bunedenle SKEO’nun belirtilen dozlarda diğer memeliler için degüvenli olduğu düşünülmektedir.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.12991/marupj.318614
- https://dergipark.org.tr/en/download/article-file/317096
- OA Status
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- Cited By
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- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W2610032109Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.12991/marupj.318614Digital Object Identifier
- Title
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Chemical composition, acute and sub-acute toxicity of Satureja khuzestanica essential oil in miceWork title
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articleOpenAlex work type
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enPrimary language
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2017Year of publication
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2017-06-20Full publication date if available
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Shirzad Fallahi, Maryam Beyranvand, Hossein Mahmoudvand, Hassan Nayebzadeh, Farnaz Kheirandish, Sareh JahanbakhshList of authors in order
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https://doi.org/10.12991/marupj.318614Publisher landing page
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https://dergipark.org.tr/en/download/article-file/317096Direct link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://dergipark.org.tr/en/download/article-file/317096Direct OA link when available
- Concepts
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Acute toxicity, Carvacrol, Satureja, Medicine, Toxicity, Essential oil, Traditional medicine, Pharmacology, Toxicology, Chemistry, Chromatography, Internal medicine, BiologyTop concepts (fields/topics) attached by OpenAlex
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14Total citation count in OpenAlex
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2025: 4, 2024: 3, 2023: 2, 2022: 1, 2021: 1Per-year citation counts (last 5 years)
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23Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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