Chemical Profiling, Antioxidant, Antiproliferative, and Antibacterial Potentials of Chemically Characterized Extract of Citrullus colocynthis L. Seeds Article Swipe
Mohammed Bourhia
,
Kaoutar Bouothmany
,
Hanane Bakrim
,
Safaa Hadrach
,
Ahmad Mohammad Salamatullah
,
Abdulhakeem Alzahrani
,
Heba Khalil Alyahya
,
Nawal A. Albadr
,
Said Gmοuh
,
Amin Laglaoui
,
Mohammed El Mzibri
,
Laïla Benbacer
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/separations8080114
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/separations8080114
Background: Citrullus colocynthis L. (C. colocynthis) is commonly known as colocynth. It belongs to the family Cucurbitaceae that is frequently used in alternative medicine in the north of Africa. The aim of the study: the present research was undertaken to investigate the chemical composition, antioxidant, antiproliferative, and antibacterial potentials of C. colocynthis seed extract. Material and methods: the chemical composition of C. colocynthis seed organic extract was characterized using gas chromatography/mass spectrometry (GC-MS). The antioxidant property was carried out using both β-carotene bleaching and DPPH assays. The antibacterial effect was effectuated using the agar disc diffusion method. The antiproliferative activity vs. human colorectal adenocarcinoma cell line (HT-29) and human breast adenocarcinoma cell line (MDA MB 231) were carried by WST-1 test. The chemical analysis showed the presence of interesting potentially bioactive compounds. The studied plant extract exhibited antioxidant potential with IC50 value of 2. 22 mg/mL (β-carotene bleaching) and 8.98 ± 0.619 mg/mL (DPPH). Concerning the antiproliferative activity, the seed extract was effective in MDA-MB-231 and HT-29 cancer cells with IC50 values 86.89 ± 3.395 and 242.1 ± 17.9 μg/mL, respectively, whilst the extract of Citrullus colocynthis seeds was non-toxic in healthy human dermal fibroblasts. Regarding the antibacterial test, the extract was effective in Gram-positive bacteria only. Conclusion: The outcome of this research indicated that the extracts from C. colocynthis seeds may compose a promising source with interesting compounds that can be used to fight cancer, free radicals damage, and bacterial infections.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/separations8080114
- https://www.mdpi.com/2297-8739/8/8/114/pdf?version=1628477529
- OA Status
- gold
- Cited By
- 38
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3190585132
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3190585132Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/separations8080114Digital Object Identifier
- Title
-
Chemical Profiling, Antioxidant, Antiproliferative, and Antibacterial Potentials of Chemically Characterized Extract of Citrullus colocynthis L. SeedsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-08-04Full publication date if available
- Authors
-
Mohammed Bourhia, Kaoutar Bouothmany, Hanane Bakrim, Safaa Hadrach, Ahmad Mohammad Salamatullah, Abdulhakeem Alzahrani, Heba Khalil Alyahya, Nawal A. Albadr, Said Gmοuh, Amin Laglaoui, Mohammed El Mzibri, Laïla BenbacerList of authors in order
- Landing page
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https://doi.org/10.3390/separations8080114Publisher landing page
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https://www.mdpi.com/2297-8739/8/8/114/pdf?version=1628477529Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2297-8739/8/8/114/pdf?version=1628477529Direct OA link when available
- Concepts
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Citrullus colocynthis, DPPH, Traditional medicine, Chemistry, Antioxidant, IC50, Antibacterial activity, Bacteria, Botany, Food science, Biochemistry, In vitro, Biology, Medicine, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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38Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8, 2024: 4, 2023: 14, 2022: 11, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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50Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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