Chikungunya virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans Article Swipe
Rimjhim Agarwal
,
James Chang
,
Fernanda Heloise Côrtes
,
Calvin Ha
,
John Villalpando
,
Izabella N. Castillo
,
Rosa Isela Gálvez
,
Alba Grifoni
,
Alessandro Sette
,
Claudia M. Romero-Vivas
,
Mark T. Heise
,
Lakshmanane Premkumar
,
Andrew K. Falconar
,
Daniela Weiskopf
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.xcrm.2025.102134
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.xcrm.2025.102134
Chikungunya virus (CHIKV) is a mosquito-borne virus that can cause chronic chikungunya virus disease (CHIKVD), which is characterized by persistent incapacitating arthralgia. Despite recurring CHIKV outbreaks and recent approval of a vaccine, the breadth and target of T cell responses in CHIKVD remain largely understudied. Here, we tested peripheral blood mononuclear cells (PBMCs) collected from CHIKV-infected individuals against overlapping peptide pools sequentially spanning the entire CHIKV proteome. We detected robust CHIKV-specific CD4+, but not CD8+, T cell responses in infected individuals. Individuals with chronic arthralgia displayed significantly higher CD4+ T cell responses against nsP1, nsP2, and E2 proteins and exhibited a significantly lower Th1 CD4+ T cell population, compared to individuals who had recovered. Additionally, CD4+ T cells in chronic individuals were marked by a predominant production of tumor necrosis factor alpha (TNF-α). Overall, our work comprehensively characterizes T cell responses in CHIKVD in humans and provides insights into the role of T cells in CHIKVD.
Related Topics
Concepts
Chikungunya
Virology
Virus
Alphavirus
Disease
Chikungunya fever
Medicine
Biology
Immunology
Pathology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.xcrm.2025.102134
- OA Status
- gold
- Cited By
- 5
- References
- 65
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410541722
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410541722Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.xcrm.2025.102134Digital Object Identifier
- Title
-
Chikungunya virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humansWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-01Full publication date if available
- Authors
-
Rimjhim Agarwal, James Chang, Fernanda Heloise Côrtes, Calvin Ha, John Villalpando, Izabella N. Castillo, Rosa Isela Gálvez, Alba Grifoni, Alessandro Sette, Claudia M. Romero-Vivas, Mark T. Heise, Lakshmanane Premkumar, Andrew K. Falconar, Daniela WeiskopfList of authors in order
- Landing page
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https://doi.org/10.1016/j.xcrm.2025.102134Publisher landing page
- Open access
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.xcrm.2025.102134Direct OA link when available
- Concepts
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Chikungunya, Virology, Virus, Alphavirus, Disease, Chikungunya fever, Medicine, Biology, Immunology, PathologyTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 5Per-year citation counts (last 5 years)
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65Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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