Childhood Asthma and Type 1 Diabetes Mellitus: A Meta-analysis and Bidirectional Mendelian Randomization Study Article Swipe
Xiaowen Zhang
,
Junyang Xie
,
Chen Gui
,
Tianhao Liang
,
Ang Li
,
Weixing Liu
,
Yiyan Wang
,
Xiaofen Wang
,
Xiaoxuan Kuang
,
Wenjing Liao
,
Lijuan Song
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.22541/au.170668095.59081440/v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.22541/au.170668095.59081440/v1
Objectives: World-wide incidence and prevalence of both asthma and type 1 diabetes mellitus (T1DM) has been increasing in past decades. Association between the two diseases has been found in some but not other studies. We conducted a meta-analysis to verify such an association, and bidirectional Mendelian randomization analysis to examine the potential cause-effect relationships. Methods: Three databases(PubMed, Embase and Web of Science) were searched from their inception to February 1, 2021. Pooled hazard ratios (HR) or odds ratios (OR), and 95% confidence intervals, were calculated. Associations between single-nucleotide polymorphisms with childhood asthma and T1DM were selected based on genome-wide association studies. The outcome datasets were obtained from FinnGen study. We used the inverse variance-weighted, weighted median and MR-Egger methods to estimate causal effects. To assess robustness and horizontal pleiotropy, MR-Egger regression and MR pleiotropy residual sum and outlier test was conducted. Results: In meta-analysis, childhood asthma was associated with an increased risk of T1DM (HR=1.30, 95% CI 1.05–1.61, P =0.014), whereas T1DM was not associated with the risk of asthma (HR=0.98, 95% CI 0.64–1.51, P =0.941; OR=0.84, 95% CI 0.65–1.08, P =0.168). MR analysis indicated increased genetic risk of T1DM in children with asthma (OR=1.308; 95% CI 1.030-1.661; P =0.028). Analysis using the IVW method indicated decreased genetic risk of asthma in children with T1DM (OR = 0.937, 95%CI 0.881-0.996, P = 0.037). Conclusions: Childhood asthma is a risk factor for T1DM; T1DM is a possible protective factor for childhood asthma.
Related Topics
Concepts
Mendelian randomization
Medicine
Meta-analysis
Asthma
Odds ratio
Hazard ratio
Confidence interval
Publication bias
Internal medicine
Single-nucleotide polymorphism
Genetics
Biology
Genotype
Genetic variants
Gene
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.22541/au.170668095.59081440/v1
- https://www.authorea.com/doi/pdf/10.22541/au.170668095.59081440
- OA Status
- gold
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391392867
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391392867Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.22541/au.170668095.59081440/v1Digital Object Identifier
- Title
-
Childhood Asthma and Type 1 Diabetes Mellitus: A Meta-analysis and Bidirectional Mendelian Randomization StudyWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-01-31Full publication date if available
- Authors
-
Xiaowen Zhang, Junyang Xie, Chen Gui, Tianhao Liang, Ang Li, Weixing Liu, Yiyan Wang, Xiaofen Wang, Xiaoxuan Kuang, Wenjing Liao, Lijuan SongList of authors in order
- Landing page
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https://doi.org/10.22541/au.170668095.59081440/v1Publisher landing page
- PDF URL
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https://www.authorea.com/doi/pdf/10.22541/au.170668095.59081440Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.authorea.com/doi/pdf/10.22541/au.170668095.59081440Direct OA link when available
- Concepts
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Mendelian randomization, Medicine, Meta-analysis, Asthma, Odds ratio, Hazard ratio, Confidence interval, Publication bias, Internal medicine, Single-nucleotide polymorphism, Genetics, Biology, Genotype, Genetic variants, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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39Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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