Chitosan Hydrogels Crosslinked with Oxidized Sucrose for Antimicrobial Applications Article Swipe
Sayaka Fujita
,
Hijiri Takeda
,
Junki Noda
,
Haruki Wakamori
,
Hiroyuki Kono
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/gels9100786
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/gels9100786
Oxidized sucrose (OS) reacts with amino-group-containing polysaccharides, including chitosan, without catalyst, resulting in hydrogels entirely composed of carbohydrates. The presence of imine bonds with low structural stabilities and unreacted aldehydes in the structures of these hydrogels hinder their application as biomaterials. Therefore, herein, the chitosan hydrogels (CTSGs) obtained after the crosslinking of chitosan with OS were reduced using sodium borohydride to convert imine bonds to secondary amines and aldehydes to alcohols. The structures of CTSGs were comprehensively characterized using Fourier transform infrared and 13C nuclear magnetic resonance spectroscopies, and the results implied that the degree of crosslinking (CR) depended on the OS feed amount used during CTSG preparation. The properties of CTSGs were significantly dependent on CR; with an increase in CR, the thermal stabilities and dynamic moduli of CTSGs increased, whereas their swelling properties decreased. CTSGs exhibited antimicrobial properties against the gram-negative bacterium Escherichia coli, and their performances were also dependent on CR. The results indicated the potentials of CTSGs completely based on carbohydrates as antimicrobial hydrogels for various medical and pharmaceutical applications. We believe that this study will contribute to the development of hydrogels for application in the food, medical, and pharmaceutical fields.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/gels9100786
- https://www.mdpi.com/2310-2861/9/10/786/pdf?version=1695977463
- OA Status
- gold
- Cited By
- 4
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387187650
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387187650Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/gels9100786Digital Object Identifier
- Title
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Chitosan Hydrogels Crosslinked with Oxidized Sucrose for Antimicrobial ApplicationsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-09-29Full publication date if available
- Authors
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Sayaka Fujita, Hijiri Takeda, Junki Noda, Haruki Wakamori, Hiroyuki KonoList of authors in order
- Landing page
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https://doi.org/10.3390/gels9100786Publisher landing page
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https://www.mdpi.com/2310-2861/9/10/786/pdf?version=1695977463Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2310-2861/9/10/786/pdf?version=1695977463Direct OA link when available
- Concepts
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Self-healing hydrogels, Chitosan, Sodium borohydride, Antimicrobial, Chemistry, Swelling, Imine, Polysaccharide, Polymer chemistry, Fourier transform infrared spectroscopy, Chemical engineering, Organic chemistry, Nuclear chemistry, Catalysis, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 1Per-year citation counts (last 5 years)
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47Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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