Choreography of budding yeast chromosomes during the cell cycle Article Swipe
Luciana Lazar‐Stefanita
,
Vittore F. Scolari
,
Guillaume Mercy
,
Agnès Thierry
,
Héloïse Muller
,
Julien Mozziconacci
,
Romain Koszul
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1101/096826
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1101/096826
To ensure the proper transmission of the genetic information, DNA molecules must be faithfully duplicated and segregated. These processes involve dynamic modifications of chromosomes internal structure to promote their individualization, as well as their global repositioning into daughter cells (Guacci et al., 1994; Kleckner et al., 2014; Mizuguchi et al., 2014). In eukaryotes, these events are regulated by conserved architectural proteins, such as structural maintenance of chromosomes (SMC i.e. cohesin and condensin) complexes (Aragon et al., 2013a; Uhlmann, 2016). Although the roles of these factors have been actively investigated, the genome-wide chromosomal architecture and dynamics both at small and large-scales during cell division remains elusive. Here we report a comprehensive Hi-C (Dekker et al., 2002; Lieberman-Aiden et al., 2009) analysis of the dynamic changes of chromosomes structure over the Saccharomyces cerevisiae cell cycle. We uncover specific SMC-dependent structural transitions between the different phases of the mitotic cycle. During replication, cohesion establishment promotes the increase of long-range intra-chromosomal contacts. This process correlates with the individualization of chromosomes, which culminates at metaphase. Mitotic chromosomes are then abruptly reorganized in anaphase by the mechanical forces exerted by the mitotic spindle on the centromere cluster. The formation of a condensin-dependent loop, that bridges centromere cluster with the cenproximal flanking region of the rDNA, suggests that these forces may directly facilitate nucleolus segregation. This work provides a comprehensive overview of chromosome dynamics during the cell cycle of a unicellular eukaryote that recapitulates and unveils new features of highly conserved stages of the cell division.
Related Topics
Concepts
Cohesin
Biology
Centromere
Chromosome segregation
Mitosis
Condensin
Anaphase
Genetics
Cell cycle
Chromatin
Cell biology
Metaphase
Cell division
Genome
Chromosome
DNA
Cell
Gene
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/096826
- https://www.biorxiv.org/content/biorxiv/early/2016/12/30/096826.full.pdf
- OA Status
- green
- Cited By
- 7
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2561883008
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W2561883008Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/096826Digital Object Identifier
- Title
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Choreography of budding yeast chromosomes during the cell cycleWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2016Year of publication
- Publication date
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2016-12-30Full publication date if available
- Authors
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Luciana Lazar‐Stefanita, Vittore F. Scolari, Guillaume Mercy, Agnès Thierry, Héloïse Muller, Julien Mozziconacci, Romain KoszulList of authors in order
- Landing page
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https://doi.org/10.1101/096826Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2016/12/30/096826.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2016/12/30/096826.full.pdfDirect OA link when available
- Concepts
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Cohesin, Biology, Centromere, Chromosome segregation, Mitosis, Condensin, Anaphase, Genetics, Cell cycle, Chromatin, Cell biology, Metaphase, Cell division, Genome, Chromosome, DNA, Cell, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
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2025: 1, 2022: 1, 2019: 2, 2018: 1, 2017: 2Per-year citation counts (last 5 years)
- References (count)
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36Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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