Choroidal Patterns in Stargardt Disease: Correlations with Visual Acuity and Disease Progression Article Swipe
Alessandro Arrigo
,
Alessio Grazioli
,
Francesco Romano
,
Emanuela Aragona
,
Alessandro Bordato
,
Carlo Di Nunzio
,
Andrea Sperti
,
Francesco Bandello
,
Maurízio Battaglia Parodi
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/jcm8091388
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/jcm8091388
Background: To identify different choroidal patterns in Stargardt disease (STGD) and to assess their clinical correlates. Methods: 100 STGD eyes (29 males; mean age 42.6 ± 16.5 years) and 100 control eyes (29 males; mean age 43.2 ± 8.5 years) were included. Optical coherence tomography (OCT) and OCT angiography (OCTA) images were obtained. Four different choroidal patterns, quantitative OCT and OCTA parameters were assessed and statistically analyzed. The main outcome was the correlation between each choroidal pattern and anatomical and functional retinal status. Furthermore, we assessed structural and best corrected visual acuity (BCVA) changes of each STGD subgroup after one-year. Results: Mean BCVA was 0.63 ± 0.44 LogMAR for STGD patients and 0.0 ± 0.0 LogMAR for controls (p < 0.01). All quantitative parameters appeared deteriorated in STGD compared to controls (p < 0.01). Choroidal patterns were distributed as follows: Pattern 1 (normal appearing choroid) (15%), Pattern 2 (reduced Sattler or Haller layer) (29%), Pattern 3 (reduced Sattler and Haller layers) (26%), Pattern 4 (Pattern 3 + choroidal caverns) (30%). More advanced patterns significantly correlated with a more severe loss of retinal structural integrity. Furthermore, only Pattern 3 and Pattern 4 showed remarkable signs of progression after one year. Conclusions: Choroidal patterns were related with retinal structural status and BCVA loss, and with different disease progression.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm8091388
- https://www.mdpi.com/2077-0383/8/9/1388/pdf?version=1567672225
- OA Status
- gold
- Cited By
- 21
- References
- 13
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2971484574
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2971484574Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jcm8091388Digital Object Identifier
- Title
-
Choroidal Patterns in Stargardt Disease: Correlations with Visual Acuity and Disease ProgressionWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-09-05Full publication date if available
- Authors
-
Alessandro Arrigo, Alessio Grazioli, Francesco Romano, Emanuela Aragona, Alessandro Bordato, Carlo Di Nunzio, Andrea Sperti, Francesco Bandello, Maurízio Battaglia ParodiList of authors in order
- Landing page
-
https://doi.org/10.3390/jcm8091388Publisher landing page
- PDF URL
-
https://www.mdpi.com/2077-0383/8/9/1388/pdf?version=1567672225Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2077-0383/8/9/1388/pdf?version=1567672225Direct OA link when available
- Concepts
-
Medicine, Stargardt disease, Visual acuity, Disease, Optometry, Ophthalmology, Macular degeneration, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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21Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 2, 2023: 4, 2022: 5, 2021: 5Per-year citation counts (last 5 years)
- References (count)
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13Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.subgroup | 97 |
| abstract_inverted_index.Choroidal | 134, 200 |
| abstract_inverted_index.Stargardt | 7 |
| abstract_inverted_index.analyzed. | 66 |
| abstract_inverted_index.appearing | 143 |
| abstract_inverted_index.choroidal | 4, 55, 75, 167 |
| abstract_inverted_index.coherence | 43 |
| abstract_inverted_index.corrected | 89 |
| abstract_inverted_index.different | 3, 54, 213 |
| abstract_inverted_index.included. | 41 |
| abstract_inverted_index.obtained. | 52 |
| abstract_inverted_index.one-year. | 99 |
| abstract_inverted_index.patterns, | 56 |
| abstract_inverted_index.anatomical | 78 |
| abstract_inverted_index.correlated | 174 |
| abstract_inverted_index.functional | 80 |
| abstract_inverted_index.integrity. | 183 |
| abstract_inverted_index.parameters | 61, 123 |
| abstract_inverted_index.remarkable | 192 |
| abstract_inverted_index.structural | 86, 182, 206 |
| abstract_inverted_index.tomography | 44 |
| abstract_inverted_index.Background: | 0 |
| abstract_inverted_index.angiography | 48 |
| abstract_inverted_index.correlates. | 15 |
| abstract_inverted_index.correlation | 72 |
| abstract_inverted_index.distributed | 137 |
| abstract_inverted_index.progression | 195 |
| abstract_inverted_index.Conclusions: | 199 |
| abstract_inverted_index.Furthermore, | 83, 184 |
| abstract_inverted_index.deteriorated | 125 |
| abstract_inverted_index.progression. | 215 |
| abstract_inverted_index.quantitative | 57, 122 |
| abstract_inverted_index.significantly | 173 |
| abstract_inverted_index.statistically | 65 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5008263008 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I154387261, https://openalex.org/I4210153126, https://openalex.org/I4387155925 |
| citation_normalized_percentile.value | 0.77039716 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |