Choroidal Thickness in Different Types of Inherited Retinal Dystrophies Article Swipe
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· 2020
· Open Access
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· DOI: https://doi.org/10.18502/jovr.v15i3.7454
Purpose: To compare the choroidal thickness among eyes with retinitis pigmentosa (RP), Stargardt disease, Usher syndrome, cone-rod dystrophy, and healthy eyes of sex- and age-matched individuals. Methods: In this comparative study, 503 eyes with RP (n = 264), cone-rod dystrophy (n = 109), Stargardt disease (n = 76), and Usher syndrome (n = 54) were included. To validate the data, 109 healthy eyes of 56 sex- and age-matched individuals were studied as controls. Choroidal imaging was performed using enhanced depth imaging-optical coherence tomography. Choroidal thickness was measured manually using MATLAB software at 13 points in nasal and temporal directions from the foveal center with the interval of 500 μm and the choroidal area encompassing the measured points was calculated automatically. Results: The mean age was 36.33 ± 13.07 years (range, 5 to 72 years). The mean choroidal thickness at 13 points of the control eyes was statistically significantly higher than that in eyes with RP (P < 0.001) and Usher syndrome (P < 0.05), but not significantly different from that in eyes with Stargardt disease and cone-rod dystrophy. Among different inherited retinal dystrophies (IRDs), the choroidal thickness was the lowest in eyes with RP (P < 0.001). Choroidal thickness in the subfoveal area correlated negatively with best-corrected visual acuity (r = −0.264, P < 0.001) and the duration of ocular symptoms (r = −0.341, P < 0.001) in all studied IRDs. No significant correlation was observed between the subfoveal choroidal thickness and central macular thickness (r = −0.24, P = 0.576). Conclusion: Choroidal thinning in four different types of IRDs does not follow a similar pattern and depends on the type of IRD and the duration of ocular symptoms. A larger cohort is required to verify these findings.
Related Topics
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.18502/jovr.v15i3.7454
- https://knepublishing.com/index.php/JOVR/article/download/7454/13068
- OA Status
- gold
- Cited By
- 12
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3048028236
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3048028236Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.18502/jovr.v15i3.7454Digital Object Identifier
- Title
-
Choroidal Thickness in Different Types of Inherited Retinal DystrophiesWork title
- Type
-
reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-07-29Full publication date if available
- Authors
-
Hamideh Sabbaghi, Hamid Ahmadieh, Jalil Jalili, Nazanin Behnaz, Maryam Fakhri, Fatemeh Suri, Mojtaba Vand Rajabpour, Morteza Entezari, Narsis DaftarianList of authors in order
- Landing page
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https://doi.org/10.18502/jovr.v15i3.7454Publisher landing page
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https://knepublishing.com/index.php/JOVR/article/download/7454/13068Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://knepublishing.com/index.php/JOVR/article/download/7454/13068Direct OA link when available
- Concepts
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Medicine, Ophthalmology, Retinitis pigmentosa, Visual acuity, Retinal, Optical coherence tomography, Choroid, Retina, Optometry, Optics, PhysicsTop concepts (fields/topics) attached by OpenAlex
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12Total citation count in OpenAlex
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2025: 2, 2024: 3, 2023: 4, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
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25Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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