Chronic Mild Stress Modulates Activity-Dependent Transcription of BDNF in Rat Hippocampal Slices Article Swipe
Raffaella Molteni
,
A.C. Rossetti
,
Elisa Savino
,
Giorgio Racagni
,
Francesca Calabrese
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1155/2016/2592319
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1155/2016/2592319
Although activity-dependent transcription represents a crucial mechanism for long-lasting experience-dependent changes in the hippocampus, limited data exist on its contribution to pathological conditions. We aim to investigate the influence of chronic stress on the activity-dependent transcription of brain-derived neurotrophic factor (BDNF). The ex vivo methodology of acute stimulation of hippocampal slices obtained from rats exposed to chronic mild stress (CMS) was used to evaluate whether the adverse experience may alter activity-dependent BDNF gene expression. CMS reduces BDNF expression and that acute depolarization significantly upregulates total BDNF mRNA levels only in control animals, showing that CMS exposure may alter BDNF transcription under basal conditions and during neuronal activation. Moreover, while the basal effect of CMS on total BDNF reflects parallel modulations of all the transcripts examined, isoform-specific changes were found after depolarization. This different effect was also observed in the activation of intracellular signaling pathways related to the neurotrophin. In conclusion, our study discloses a functional alteration of BDNF transcription as a consequence of stress. Being the activity-regulated transcription a critical process in synaptic and neuronal plasticity, the different regulation of individual BDNF promoters may contribute to long-lasting changes, which are fundamental for the vulnerability of the hippocampus to stress-related diseases.
Related Topics
Concepts
Hippocampal formation
Transcription factor
Premovement neuronal activity
Neurotrophic factors
Brain-derived neurotrophic factor
Neuroscience
Neurotrophin
Neuroplasticity
Biology
Transcription (linguistics)
Internal medicine
Endocrinology
Cell biology
Chemistry
Medicine
Receptor
Gene
Genetics
Linguistics
Philosophy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2016/2592319
- http://downloads.hindawi.com/journals/np/2016/2592319.pdf
- OA Status
- gold
- Cited By
- 22
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2287370869
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2287370869Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1155/2016/2592319Digital Object Identifier
- Title
-
Chronic Mild Stress Modulates Activity-Dependent Transcription of BDNF in Rat Hippocampal SlicesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-12-31Full publication date if available
- Authors
-
Raffaella Molteni, A.C. Rossetti, Elisa Savino, Giorgio Racagni, Francesca CalabreseList of authors in order
- Landing page
-
https://doi.org/10.1155/2016/2592319Publisher landing page
- PDF URL
-
https://downloads.hindawi.com/journals/np/2016/2592319.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://downloads.hindawi.com/journals/np/2016/2592319.pdfDirect OA link when available
- Concepts
-
Hippocampal formation, Transcription factor, Premovement neuronal activity, Neurotrophic factors, Brain-derived neurotrophic factor, Neuroscience, Neurotrophin, Neuroplasticity, Biology, Transcription (linguistics), Internal medicine, Endocrinology, Cell biology, Chemistry, Medicine, Receptor, Gene, Genetics, Linguistics, PhilosophyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
22Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 3, 2022: 1, 2021: 1, 2020: 4Per-year citation counts (last 5 years)
- References (count)
-
39Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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