Chronic Stress Leads to Differentiation of Mice by Glucocorticoid Sensitivity into Groups Characterized by Specific Behavioral Phenotype Article Swipe

PDF

Polina Ritter , Rasha Salman , Yuliya Ryabushkina , Natalya Bondar ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.20944/preprints202511.1151.v1

Chronic stress alters hypothalamic-pituitary-adrenal (HPA) axis function, influencing corticosterone regulation and adaptive responses. Identifying distinct response patterns can provide insight into individual variability in stress adaptation. This study is aimed to assess variability in HPA axis sensitivity following chronic social defeat stress. Male C57BL6 mice were exposed to chronic social defeat stress (CSDS) for 30 days. In order to evaluate integrity of negative feedback loop of HPA axis dexamethasone suppression test (DST) was used. Corticosterone levels were measured following saline or low-dose dexamethasone administration at 10 and 30 days. K-means clustering by corticosterone levels after saline and dexamethasone administration was applied to identify distinct response profiles. Behavioral testing (open field, elevated plus maze, social interaction test, partition, social defeat, forced swimming test, sucrose preference test) and qPCR analysis of HPA axis-related genes in hypothalamus (Crh, Crhr1, Crhbp, Fkbp5, Nr3c1), pituitary gland (Pomc, Crhr1, Nr3c1, Nr3c2), and corticosterone synthesis genes in adrenal glands (Cyp11a1, Cyp11b1, Hsd11b1, Mc2r, Star, Fkbp5, Nr3c1) was performed. Cluster analysis identified 3 distinct response profiles differing in baseline and dexamethasone-suppressed corticosterone levels. Clusters also exhibited differences in behavioral phenotypes and HPA axis gene expression. Cluster 1 showed low basal corticosterone and an abnormal dexamethasone suppression response, without significant Crh or Crhbp dysregulation in the hypothalamus. Cluster 2 exhibited elevated basal corticosterone, a blunted dexamethasone response, anhedonia, and reduced immobility in the forced swim test; increased Crh and reduced Fkbp5 suggest enhanced glucocorticoid receptor sensitivity and sustained hypercortisolemia. Cluster 3, characterized by normal basal corticosterone and normal dexamethasone response, showed upregulation of Crh and Crhbp, consistent with balanced and potentially adaptive HPA axis regulation under chronic stress. Corticosterone response heterogeneity reflects distinct adaptive trajectories under chronic stress. Identifying behavioral markers of these strategies may improve understanding of stress vulnerability and resilience mechanisms, with implications for stress-related disorders.

Related Topics

Endocrinology

Internal Medicine

Glucocorticoid

Glucocorticoid Receptor

Hypothalamus

Biology

Saline (Medicine)

Corticotropin-Releasing Hormone

Concepts

Corticosterone Endocrinology Internal medicine Glucocorticoid Dexamethasone Glucocorticoid receptor Basal (medicine) Dexamethasone suppression test Social defeat Social stress Chronic stress Behavioural despair test Hypothalamus FKBP5 Biology Hypothalamic–pituitary–adrenal axis Saline Corticotropin-releasing hormone Corticosteroid Adrenal gland Psychology Downregulation and upregulation Steroid hormone Phenotype Gene expression

Metadata

Type: article
Landing Page: https://doi.org/10.20944/preprints202511.1151.v1
PDF: https://www.preprints.org/frontend/manuscript/31eb4756a03688f4e32a29474b254fd2/download_pub
OA Status: green
OpenAlex ID: https://openalex.org/W7105895290

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W7105895290

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.20944/preprints202511.1151.v1

Digital Object Identifier
Title: Chronic Stress Leads to Differentiation of Mice by Glucocorticoid Sensitivity into Groups Characterized by Specific Behavioral Phenotype

Work title
Type: article

OpenAlex work type
Publication year: 2025

Year of publication
Publication date: 2025-11-17

Full publication date if available
Authors: Polina Ritter, Rasha Salman, Yuliya Ryabushkina, Natalya Bondar

List of authors in order
Landing page: https://doi.org/10.20944/preprints202511.1151.v1

Publisher landing page
PDF URL: https://www.preprints.org/frontend/manuscript/31eb4756a03688f4e32a29474b254fd2/download_pub

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: green

Open access status per OpenAlex
OA URL: https://www.preprints.org/frontend/manuscript/31eb4756a03688f4e32a29474b254fd2/download_pub

Direct OA link when available
Concepts: Corticosterone, Endocrinology, Internal medicine, Glucocorticoid, Dexamethasone, Glucocorticoid receptor, Basal (medicine), Dexamethasone suppression test, Social defeat, Social stress, Chronic stress, Behavioural despair test, Hypothalamus, FKBP5, Biology, Hypothalamic–pituitary–adrenal axis, Saline, Corticotropin-releasing hormone, Corticosteroid, Adrenal gland, Psychology, Downregulation and upregulation, Steroid hormone, Phenotype, Gene expression

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex

Full payload

id	https://openalex.org/W7105895290
doi	https://doi.org/10.20944/preprints202511.1151.v1
ids.doi	https://doi.org/10.20944/preprints202511.1151.v1
ids.openalex	https://openalex.org/W7105895290
fwci	0.0
type	article
title	Chronic Stress Leads to Differentiation of Mice by Glucocorticoid Sensitivity into Groups Characterized by Specific Behavioral Phenotype
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T10529
topics[0].field.id	https://openalex.org/fields/28
topics[0].field.display_name	Neuroscience
topics[0].score	0.9850701093673706
topics[0].domain.id	https://openalex.org/domains/1
topics[0].domain.display_name	Life Sciences
topics[0].subfield.id	https://openalex.org/subfields/2802
topics[0].subfield.display_name	Behavioral Neuroscience
topics[0].display_name	Stress Responses and Cortisol
topics[1].id	https://openalex.org/T10489
topics[1].field.id	https://openalex.org/fields/28
topics[1].field.display_name	Neuroscience
topics[1].score	0.002352578565478325
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/2807
topics[1].subfield.display_name	Endocrine and Autonomic Systems
topics[1].display_name	Regulation of Appetite and Obesity
topics[2].id	https://openalex.org/T10056
topics[2].field.id	https://openalex.org/fields/28
topics[2].field.display_name	Neuroscience
topics[2].score	0.0013077683979645371
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/2804
topics[2].subfield.display_name	Cellular and Molecular Neuroscience
topics[2].display_name	Neurotransmitter Receptor Influence on Behavior
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2780352252
concepts[0].level	3
concepts[0].score	0.926401674747467
concepts[0].wikidata	https://www.wikidata.org/wiki/Q422543
concepts[0].display_name	Corticosterone
concepts[1].id	https://openalex.org/C134018914
concepts[1].level	1
concepts[1].score	0.8591057658195496
concepts[1].wikidata	https://www.wikidata.org/wiki/Q162606
concepts[1].display_name	Endocrinology
concepts[2].id	https://openalex.org/C126322002
concepts[2].level	1
concepts[2].score	0.8465462923049927
concepts[2].wikidata	https://www.wikidata.org/wiki/Q11180
concepts[2].display_name	Internal medicine
concepts[3].id	https://openalex.org/C2780841215
concepts[3].level	2
concepts[3].score	0.7828363180160522
concepts[3].wikidata	https://www.wikidata.org/wiki/Q422549
concepts[3].display_name	Glucocorticoid
concepts[4].id	https://openalex.org/C2780401358
concepts[4].level	2
concepts[4].score	0.671406090259552
concepts[4].wikidata	https://www.wikidata.org/wiki/Q422252
concepts[4].display_name	Dexamethasone
concepts[5].id	https://openalex.org/C59493245
concepts[5].level	3
concepts[5].score	0.6685402393341064
concepts[5].wikidata	https://www.wikidata.org/wiki/Q14877410
concepts[5].display_name	Glucocorticoid receptor
concepts[6].id	https://openalex.org/C2778024521
concepts[6].level	3
concepts[6].score	0.6088860630989075
concepts[6].wikidata	https://www.wikidata.org/wiki/Q55639806
concepts[6].display_name	Basal (medicine)
concepts[7].id	https://openalex.org/C2780455818
concepts[7].level	3
concepts[7].score	0.5269500017166138
concepts[7].wikidata	https://www.wikidata.org/wiki/Q1207196
concepts[7].display_name	Dexamethasone suppression test
concepts[8].id	https://openalex.org/C2779760398
concepts[8].level	2
concepts[8].score	0.49613049626350403
concepts[8].wikidata	https://www.wikidata.org/wiki/Q7551043
concepts[8].display_name	Social defeat
concepts[9].id	https://openalex.org/C16634123
concepts[9].level	2
concepts[9].score	0.42763254046440125
concepts[9].wikidata	https://www.wikidata.org/wiki/Q7551393
concepts[9].display_name	Social stress
concepts[10].id	https://openalex.org/C2778654844
concepts[10].level	2
concepts[10].score	0.420025110244751
concepts[10].wikidata	https://www.wikidata.org/wiki/Q3305232
concepts[10].display_name	Chronic stress
concepts[11].id	https://openalex.org/C136569192
concepts[11].level	4
concepts[11].score	0.4177194833755493
concepts[11].wikidata	https://www.wikidata.org/wiki/Q4880745
concepts[11].display_name	Behavioural despair test
concepts[12].id	https://openalex.org/C2777003273
concepts[12].level	2
concepts[12].score	0.4110535681247711
concepts[12].wikidata	https://www.wikidata.org/wiki/Q164386
concepts[12].display_name	Hypothalamus
concepts[13].id	https://openalex.org/C78150878
concepts[13].level	4
concepts[13].score	0.3909536898136139
concepts[13].wikidata	https://www.wikidata.org/wiki/Q17928600
concepts[13].display_name	FKBP5
concepts[14].id	https://openalex.org/C86803240
concepts[14].level	0
concepts[14].score	0.38325560092926025
concepts[14].wikidata	https://www.wikidata.org/wiki/Q420
concepts[14].display_name	Biology
concepts[15].id	https://openalex.org/C2779146795
concepts[15].level	3
concepts[15].score	0.38156309723854065
concepts[15].wikidata	https://www.wikidata.org/wiki/Q1369123
concepts[15].display_name	Hypothalamic–pituitary–adrenal axis
concepts[16].id	https://openalex.org/C2777397205
concepts[16].level	2
concepts[16].score	0.3752385079860687
concepts[16].wikidata	https://www.wikidata.org/wiki/Q275792
concepts[16].display_name	Saline
concepts[17].id	https://openalex.org/C2778458438
concepts[17].level	3
concepts[17].score	0.3544153869152069
concepts[17].wikidata	https://www.wikidata.org/wiki/Q386664
concepts[17].display_name	Corticotropin-releasing hormone
concepts[18].id	https://openalex.org/C2776804153
concepts[18].level	2
concepts[18].score	0.33684200048446655
concepts[18].wikidata	https://www.wikidata.org/wiki/Q210420
concepts[18].display_name	Corticosteroid
concepts[19].id	https://openalex.org/C2780694816
concepts[19].level	2
concepts[19].score	0.3323180079460144
concepts[19].wikidata	https://www.wikidata.org/wiki/Q712294
concepts[19].display_name	Adrenal gland
concepts[20].id	https://openalex.org/C15744967
concepts[20].level	0
concepts[20].score	0.3031335473060608
concepts[20].wikidata	https://www.wikidata.org/wiki/Q9418
concepts[20].display_name	Psychology
concepts[21].id	https://openalex.org/C127561419
concepts[21].level	3
concepts[21].score	0.284144788980484
concepts[21].wikidata	https://www.wikidata.org/wiki/Q224527
concepts[21].display_name	Downregulation and upregulation
concepts[22].id	https://openalex.org/C2776888042
concepts[22].level	3
concepts[22].score	0.2805403769016266
concepts[22].wikidata	https://www.wikidata.org/wiki/Q422137
concepts[22].display_name	Steroid hormone
concepts[23].id	https://openalex.org/C127716648
concepts[23].level	3
concepts[23].score	0.27062806487083435
concepts[23].wikidata	https://www.wikidata.org/wiki/Q104053
concepts[23].display_name	Phenotype
concepts[24].id	https://openalex.org/C150194340
concepts[24].level	3
concepts[24].score	0.25985586643218994
concepts[24].wikidata	https://www.wikidata.org/wiki/Q26972
concepts[24].display_name	Gene expression
keywords[0].id	https://openalex.org/keywords/corticosterone
keywords[0].score	0.926401674747467
keywords[0].display_name	Corticosterone
keywords[1].id	https://openalex.org/keywords/glucocorticoid
keywords[1].score	0.7828363180160522
keywords[1].display_name	Glucocorticoid
keywords[2].id	https://openalex.org/keywords/dexamethasone
keywords[2].score	0.671406090259552
keywords[2].display_name	Dexamethasone
keywords[3].id	https://openalex.org/keywords/glucocorticoid-receptor
keywords[3].score	0.6685402393341064
keywords[3].display_name	Glucocorticoid receptor
keywords[4].id	https://openalex.org/keywords/basal
keywords[4].score	0.6088860630989075
keywords[4].display_name	Basal (medicine)
keywords[5].id	https://openalex.org/keywords/dexamethasone-suppression-test
keywords[5].score	0.5269500017166138
keywords[5].display_name	Dexamethasone suppression test
keywords[6].id	https://openalex.org/keywords/social-defeat
keywords[6].score	0.49613049626350403
keywords[6].display_name	Social defeat
keywords[7].id	https://openalex.org/keywords/social-stress
keywords[7].score	0.42763254046440125
keywords[7].display_name	Social stress
keywords[8].id	https://openalex.org/keywords/chronic-stress
keywords[8].score	0.420025110244751
keywords[8].display_name	Chronic stress
language
locations[0].id	doi:10.20944/preprints202511.1151.v1
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S6309402219
locations[0].source.issn
locations[0].source.type	repository
locations[0].source.is_oa	True
locations[0].source.issn_l
locations[0].source.is_core	False
locations[0].source.is_in_doaj	False
locations[0].source.display_name	Preprints.org
locations[0].source.host_organization
locations[0].source.host_organization_name
locations[0].source.host_organization_lineage	https://openalex.org/P4310310987
locations[0].license	cc-by
locations[0].pdf_url	https://www.preprints.org/frontend/manuscript/31eb4756a03688f4e32a29474b254fd2/download_pub
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.20944/preprints202511.1151.v1
indexed_in	crossref
authorships[0].author.id
authorships[0].author.orcid
authorships[0].author.display_name	Polina Ritter
authorships[0].author_position	first
authorships[0].raw_author_name	Polina Ritter
authorships[0].is_corresponding	True
authorships[1].author.id	https://openalex.org/A2222281924
authorships[1].author.orcid
authorships[1].author.display_name	Rasha Salman
authorships[1].author_position	middle
authorships[1].raw_author_name	Rasha Salman
authorships[1].is_corresponding	False
authorships[2].author.id
authorships[2].author.orcid
authorships[2].author.display_name	Yuliya Ryabushkina
authorships[2].author_position	middle
authorships[2].raw_author_name	Yuliya Ryabushkina
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A2186237188
authorships[3].author.orcid
authorships[3].author.display_name	Natalya Bondar
authorships[3].author_position	last
authorships[3].raw_author_name	Natalya Bondar
authorships[3].is_corresponding	False
has_content.pdf	True
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://www.preprints.org/frontend/manuscript/31eb4756a03688f4e32a29474b254fd2/download_pub
open_access.oa_status	green
open_access.any_repository_has_fulltext	False
created_date	2025-11-18T00:00:00
display_name	Chronic Stress Leads to Differentiation of Mice by Glucocorticoid Sensitivity into Groups Characterized by Specific Behavioral Phenotype
has_fulltext	False
is_retracted	False
updated_date	2025-11-19T23:35:23.961156
primary_topic.id	https://openalex.org/T10529
primary_topic.field.id	https://openalex.org/fields/28
primary_topic.field.display_name	Neuroscience
primary_topic.score	0.9850701093673706
primary_topic.domain.id	https://openalex.org/domains/1
primary_topic.domain.display_name	Life Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2802
primary_topic.subfield.display_name	Behavioral Neuroscience
primary_topic.display_name	Stress Responses and Cortisol
cited_by_count	0
locations_count	1
best_oa_location.id	doi:10.20944/preprints202511.1151.v1
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S6309402219
best_oa_location.source.issn
best_oa_location.source.type	repository
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	Preprints.org
best_oa_location.source.host_organization
best_oa_location.source.host_organization_name
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310310987
best_oa_location.license	cc-by
best_oa_location.pdf_url	https://www.preprints.org/frontend/manuscript/31eb4756a03688f4e32a29474b254fd2/download_pub
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.20944/preprints202511.1151.v1
primary_location.id	doi:10.20944/preprints202511.1151.v1
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S6309402219
primary_location.source.issn
primary_location.source.type	repository
primary_location.source.is_oa	True
primary_location.source.issn_l
primary_location.source.is_core	False
primary_location.source.is_in_doaj	False
primary_location.source.display_name	Preprints.org
primary_location.source.host_organization
primary_location.source.host_organization_name
primary_location.source.host_organization_lineage	https://openalex.org/P4310310987
primary_location.license	cc-by
primary_location.pdf_url	https://www.preprints.org/frontend/manuscript/31eb4756a03688f4e32a29474b254fd2/download_pub
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.20944/preprints202511.1151.v1
publication_date	2025-11-17
publication_year	2025
referenced_works_count	0
abstract_inverted_index.1	188
abstract_inverted_index.2	209
abstract_inverted_index.3	164
abstract_inverted_index.a	214
abstract_inverted_index.10	85
abstract_inverted_index.3,	241
abstract_inverted_index.30	54, 87
abstract_inverted_index.In	56
abstract_inverted_index.an	194
abstract_inverted_index.at	84
abstract_inverted_index.by	91, 243
abstract_inverted_index.in	23, 33, 132, 149, 169, 179, 205, 222
abstract_inverted_index.is	28
abstract_inverted_index.of	61, 65, 128, 253, 282, 288
abstract_inverted_index.or	80, 202
abstract_inverted_index.to	30, 47, 58, 101
abstract_inverted_index.Crh	201, 228, 254
abstract_inverted_index.HPA	34, 66, 129, 183, 263
abstract_inverted_index.and	10, 86, 96, 125, 145, 171, 182, 193, 219, 229, 237, 247, 255, 260, 291
abstract_inverted_index.can	17
abstract_inverted_index.for	53, 296
abstract_inverted_index.low	190
abstract_inverted_index.may	285
abstract_inverted_index.the	206, 223
abstract_inverted_index.was	72, 99, 159
abstract_inverted_index.Male	42
abstract_inverted_index.This	26
abstract_inverted_index.also	176
abstract_inverted_index.axis	5, 35, 67, 184, 264
abstract_inverted_index.gene	185
abstract_inverted_index.into	20
abstract_inverted_index.loop	64
abstract_inverted_index.mice	44
abstract_inverted_index.plus	111
abstract_inverted_index.qPCR	126
abstract_inverted_index.swim	225
abstract_inverted_index.test	70
abstract_inverted_index.were	45, 76
abstract_inverted_index.with	258, 294
abstract_inverted_index.(Crh,	134
abstract_inverted_index.(DST)	71
abstract_inverted_index.(HPA)	4
abstract_inverted_index.(open	108
abstract_inverted_index.Crhbp	203
abstract_inverted_index.Fkbp5	231
abstract_inverted_index.Mc2r,	155
abstract_inverted_index.Star,	156
abstract_inverted_index.after	94
abstract_inverted_index.aimed	29
abstract_inverted_index.basal	191, 212, 245
abstract_inverted_index.days.	55, 88
abstract_inverted_index.genes	131, 148
abstract_inverted_index.gland	140
abstract_inverted_index.maze,	112
abstract_inverted_index.order	57
abstract_inverted_index.study	27
abstract_inverted_index.test)	124
abstract_inverted_index.test,	115, 121
abstract_inverted_index.test;	226
abstract_inverted_index.these	283
abstract_inverted_index.under	266, 276
abstract_inverted_index.used.	73
abstract_inverted_index.(CSDS)	52
abstract_inverted_index.(Pomc,	141
abstract_inverted_index.C57BL6	43
abstract_inverted_index.Crhbp,	136, 256
abstract_inverted_index.Crhr1,	135, 142
abstract_inverted_index.Fkbp5,	137, 157
abstract_inverted_index.Nr3c1)	158
abstract_inverted_index.Nr3c1,	143
abstract_inverted_index.alters	2
abstract_inverted_index.assess	31
abstract_inverted_index.defeat	40, 50
abstract_inverted_index.field,	109
abstract_inverted_index.forced	119, 224
abstract_inverted_index.glands	151
abstract_inverted_index.levels	75, 93
abstract_inverted_index.normal	244, 248
abstract_inverted_index.saline	79, 95
abstract_inverted_index.showed	189, 251
abstract_inverted_index.social	39, 49, 113, 117
abstract_inverted_index.stress	1, 24, 51, 289
abstract_inverted_index.Chronic	0
abstract_inverted_index.Cluster	161, 187, 208, 240
abstract_inverted_index.K-means	89
abstract_inverted_index.Nr3c1),	138
abstract_inverted_index.Nr3c2),	144
abstract_inverted_index.adrenal	150
abstract_inverted_index.applied	100
abstract_inverted_index.blunted	215
abstract_inverted_index.chronic	38, 48, 267, 277
abstract_inverted_index.defeat,	118
abstract_inverted_index.exposed	46
abstract_inverted_index.improve	286
abstract_inverted_index.insight	19
abstract_inverted_index.levels.	174
abstract_inverted_index.markers	281
abstract_inverted_index.provide	18
abstract_inverted_index.reduced	220, 230
abstract_inverted_index.stress.	41, 268, 278
abstract_inverted_index.sucrose	122
abstract_inverted_index.suggest	232
abstract_inverted_index.testing	107
abstract_inverted_index.without	199
abstract_inverted_index.Clusters	175
abstract_inverted_index.Cyp11b1,	153
abstract_inverted_index.Hsd11b1,	154
abstract_inverted_index.abnormal	195
abstract_inverted_index.adaptive	11, 262, 274
abstract_inverted_index.analysis	127, 162
abstract_inverted_index.balanced	259
abstract_inverted_index.baseline	170
abstract_inverted_index.distinct	14, 103, 165, 273
abstract_inverted_index.elevated	110, 211
abstract_inverted_index.enhanced	233
abstract_inverted_index.evaluate	59
abstract_inverted_index.feedback	63
abstract_inverted_index.identify	102
abstract_inverted_index.low-dose	81
abstract_inverted_index.measured	77
abstract_inverted_index.negative	62
abstract_inverted_index.patterns	16
abstract_inverted_index.profiles	167
abstract_inverted_index.receptor	235
abstract_inverted_index.reflects	272
abstract_inverted_index.response	15, 104, 166, 270
abstract_inverted_index.swimming	120
abstract_inverted_index.(Cyp11a1,	152
abstract_inverted_index.differing	168
abstract_inverted_index.exhibited	177, 210
abstract_inverted_index.following	37, 78
abstract_inverted_index.function,	6
abstract_inverted_index.increased	227
abstract_inverted_index.integrity	60
abstract_inverted_index.pituitary	139
abstract_inverted_index.profiles.	105
abstract_inverted_index.response,	198, 217, 250
abstract_inverted_index.sustained	238
abstract_inverted_index.synthesis	147
abstract_inverted_index.Behavioral	106
abstract_inverted_index.anhedonia,	218
abstract_inverted_index.behavioral	180, 280
abstract_inverted_index.clustering	90
abstract_inverted_index.consistent	257
abstract_inverted_index.disorders.	298
abstract_inverted_index.identified	163
abstract_inverted_index.immobility	221
abstract_inverted_index.individual	21
abstract_inverted_index.partition,	116
abstract_inverted_index.performed.	160
abstract_inverted_index.phenotypes	181
abstract_inverted_index.preference	123
abstract_inverted_index.regulation	9, 265
abstract_inverted_index.resilience	292
abstract_inverted_index.responses.	12
abstract_inverted_index.strategies	284
abstract_inverted_index.Identifying	13, 279
abstract_inverted_index.adaptation.	25
abstract_inverted_index.differences	178
abstract_inverted_index.expression.	186
abstract_inverted_index.influencing	7
abstract_inverted_index.interaction	114
abstract_inverted_index.mechanisms,	293
abstract_inverted_index.potentially	261
abstract_inverted_index.sensitivity	36, 236
abstract_inverted_index.significant	200
abstract_inverted_index.suppression	69, 197
abstract_inverted_index.variability	22, 32
abstract_inverted_index.axis-related	130
abstract_inverted_index.hypothalamus	133
abstract_inverted_index.implications	295
abstract_inverted_index.trajectories	275
abstract_inverted_index.upregulation	252
abstract_inverted_index.characterized	242
abstract_inverted_index.dexamethasone	68, 82, 97, 196, 216, 249
abstract_inverted_index.dysregulation	204
abstract_inverted_index.heterogeneity	271
abstract_inverted_index.hypothalamus.	207
abstract_inverted_index.understanding	287
abstract_inverted_index.vulnerability	290
abstract_inverted_index.Corticosterone	74, 269
abstract_inverted_index.administration	83, 98
abstract_inverted_index.corticosterone	8, 92, 146, 173, 192, 246
abstract_inverted_index.glucocorticoid	234
abstract_inverted_index.stress-related	297
abstract_inverted_index.corticosterone,	213
abstract_inverted_index.hypercortisolemia.	239
abstract_inverted_index.dexamethasone-suppressed	172
abstract_inverted_index.hypothalamic-pituitary-adrenal	3
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	4
citation_normalized_percentile.value	0.77051527
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False