Chronic treatment with corticosterone increases the number of tyrosine hydroxylase-expressing cells within specific nuclei of the brainstem reticular formation Article Swipe
Carla L. Busceti
,
Domenico Bucci
,
Mariarosaria Scioli
,
Paola Di Pietro
,
Ferdinando Nicoletti
,
Stefano Puglisi‐Allegra
,
Michela Ferrucci
,
Francesco Fornai
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fnana.2022.976714
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fnana.2022.976714
Cushing's syndrome is due to increased glucocorticoid levels in the body, and it is characterized by several clinical alterations which concern both vegetative and behavioral functions. The anatomical correlates of these effects remain largely unknown. Apart from peripheral effects induced by corticosteroids as counter-insular hormones, only a few reports are available concerning the neurobiology of glucocorticoid-induced vegetative and behavioral alterations. In the present study, C57 Black mice were administered daily a chronic treatment with corticosterone in drinking water. This treatment produces a significant and selective increase of TH-positive neurons within two nuclei placed in the lateral column of the brainstem reticular formation. These alterations significantly correlate with selective domains of Cushing's syndrome. Specifically, the increase of TH neurons within area postrema significantly correlates with the development of glucose intolerance, which is in line with the selective control by area postrema of vagal neurons innervating the pancreas. The other nucleus corresponds to the retrorubral field, which is involved in the behavioral activity. In detail, the retrorubral field is likely to modulate anxiety and mood disorders, which frequently occur following chronic exposure to glucocorticoids. To our knowledge, this is the first study that provides the neuroanatomical basis underlying specific symptoms occurring in Cushing's syndrome.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnana.2022.976714
- https://www.frontiersin.org/articles/10.3389/fnana.2022.976714/pdf
- OA Status
- gold
- Cited By
- 3
- References
- 62
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4307448875Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fnana.2022.976714Digital Object Identifier
- Title
-
Chronic treatment with corticosterone increases the number of tyrosine hydroxylase-expressing cells within specific nuclei of the brainstem reticular formationWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-10-28Full publication date if available
- Authors
-
Carla L. Busceti, Domenico Bucci, Mariarosaria Scioli, Paola Di Pietro, Ferdinando Nicoletti, Stefano Puglisi‐Allegra, Michela Ferrucci, Francesco FornaiList of authors in order
- Landing page
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https://doi.org/10.3389/fnana.2022.976714Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fnana.2022.976714/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fnana.2022.976714/pdfDirect OA link when available
- Concepts
-
Area postrema, Brainstem, Corticosterone, Endocrinology, Glucocorticoid, Internal medicine, Neuroscience, Neurochemical, Reticular formation, Tyrosine hydroxylase, Medicine, Biology, Psychology, Hormone, Central nervous system, DopamineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2025: 1, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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62Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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