Cicatrização de defeitos periostais na calvária entre dois tipos de membranas produzidas por meio de bioengenharia: estudo em coelhos Article Swipe

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Josemael de Oliveira Ribas-Filho , Elora Sampaio Lourenço , Fernanda Pirajá Figueiredo , Oscar Capistrano dos Santos , Sandra Oliveira de Araújo , Igor Lima Maldonado , Allan Fernando Giovanini ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.55684/2024.82.e.e068

Introdução: Simultaneamente ao desenvolvimento de novos biomateriais, abundantes modalidades cirúrgicas têm sido propostas, com a finalidade de promover adequada regeneração de defeitos ósseos, sem proporcionar fenestrações ou deiscências. Entre as tcnicas regenerativas atualmente aceitas para este propósito, destaca-se a regenerao tecidual guiada. Objetivo: Avaliar o padrão de cicatrização e a resposta histológica do organismo frente à inserção de uma membrana a base de gelatina tipo A (Marquette), e compará-la com membrana comercial. Métodos: Foram selecionadas 15 coelhas adultas. Na região parietal da calvária foram realizados retalhos para criação de uma bolsa supraperiostal e implantação de 2 tipos de membranas reabsorvíveis: membrana Marquette e membrana Bio-Gide®. Após o procedimento cirúrgico os animais foram alocados em 3 grupos randomicamente selecionados (n = 5) para o período de eutanásia, que ocorreu em 2, 4 e 6 semanas pósoperatórias. Posteriormente, as áreas da calvária foram removidas e coradas por H&E e analisadas para averiguar formação de periósteo, infiltrado inflamatório na área de inserção de membrana, degradação/reabsorção da membrana, e fibrose perimembranar. Resultados: Ao redor da membrana Bio-Gide® ocorreu discreta infiltração inflamatória e a membrana sofreu reabsorção ao decorrer do período pós-operatório com reconstrução de periósteo prevalentemente de caráter fibroso. A membrana Marquette também não desencadeou importante reação inflamatória. Contudo, não foi verificada reabsorção significativa durante o período, e também ocorreu significante formação de cápsula fibrosa cerceando toda área membranar. Conclusão: A membrana Marquette produz reação de isolamento tecidual, minimizando a formação periostal ao mesmo tempo que não proporciona sua degradação.

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Type: article
Language: pt
Landing Page: https://doi.org/10.55684/2024.82.e.e068
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DOI: https://doi.org/10.55684/2024.82.e.e068

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Title: Cicatrização de defeitos periostais na calvária entre dois tipos de membranas produzidas por meio de bioengenharia: estudo em coelhos

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Publication year: 2024

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Authors: Josemael de Oliveira Ribas-Filho, Elora Sampaio Lourenço, Fernanda Pirajá Figueiredo, Oscar Capistrano dos Santos, Sandra Oliveira de Araújo, Igor Lima Maldonado, Allan Fernando Giovanini

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