Cigarette Smoking Is Related to Endothelial Dysfunction of Resistance, but Not Conduit Arteries in the General Population—Results From the Gutenberg Health Study Article Swipe
Omar Hahad
,
Natalie Arnold
,
Jürgen H. Prochaska
,
Marina Panova‐Noeva
,
Andreas Schulz
,
Karl J. Lackner
,
Norbert Pfeiffer
,
Irene Schmidtmann
,
Matthias Michal
,
Manfred E. Beutel
,
Philipp S. Wild
,
John F. Keaney
,
Andreas Daiber
,
Thomas Münzel
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fcvm.2021.674622
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fcvm.2021.674622
Aims: Cigarette smoking is one of the most complex and least understood cardiovascular risk factors. Importantly, differences in the tobacco-related pathophysiology of endothelial dysfunction, an early event in atherogenesis, between circulatory beds remain elusive. Therefore, this study evaluated how smoking impacts endothelial function of conduit and resistance arteries in a large population-based cohort. Methods and results: 15,010 participants (aged 35–74 years) of the Gutenberg Health Study were examined at baseline from 2007 to 2012. Smoking status, pack-years of smoking, and years since quitting smoking were assessed by a computer-assisted interview. Endothelial function of conduit and resistance arteries was determined by flow-mediated dilation (FMD) of the brachial artery, reactive hyperemia index (RHI) using peripheral arterial tonometry, as well as by reflection index (RI) derived from digital photoplethysmography, respectively. Among all subjects, 45.8% had never smoked, 34.7% were former smokers, and 19.4% were current smokers. Mean cumulative smoking exposure was 22.1 ± 18.1 pack-years in current smokers and mean years since quitting was 18.9 ± 12.7 in former smokers. In multivariable linear regression models adjusted for typical confounders, smoking status, pack-years of smoking, and years since quitting smoking were independently associated with RHI and RI, while no association was found for FMD. Overall, no clear dose-dependent associations were observed between variables, whereby higher exposure tended to be associated with pronounced resistance artery endothelial dysfunction. Conclusions: Cigarette smoking is associated with altered endothelial function of resistance, but not conduit arteries. The present results suggest that smoking-induced endothelial dysfunction in different circulatory beds may exhibit a differential picture.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fcvm.2021.674622
- https://www.frontiersin.org/articles/10.3389/fcvm.2021.674622/pdf
- OA Status
- gold
- Cited By
- 41
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3161274758
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3161274758Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fcvm.2021.674622Digital Object Identifier
- Title
-
Cigarette Smoking Is Related to Endothelial Dysfunction of Resistance, but Not Conduit Arteries in the General Population—Results From the Gutenberg Health StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-05-19Full publication date if available
- Authors
-
Omar Hahad, Natalie Arnold, Jürgen H. Prochaska, Marina Panova‐Noeva, Andreas Schulz, Karl J. Lackner, Norbert Pfeiffer, Irene Schmidtmann, Matthias Michal, Manfred E. Beutel, Philipp S. Wild, John F. Keaney, Andreas Daiber, Thomas MünzelList of authors in order
- Landing page
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https://doi.org/10.3389/fcvm.2021.674622Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fcvm.2021.674622/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fcvm.2021.674622/pdfDirect OA link when available
- Concepts
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Medicine, Reactive hyperemia, Endothelial dysfunction, Brachial artery, Confounding, Cardiology, Population, Internal medicine, Cigarette smoking, Endothelium, Cohort, Vascular resistance, Hemodynamics, Vasodilation, Blood pressure, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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41Total citation count in OpenAlex
- Citations by year (recent)
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2025: 9, 2024: 16, 2023: 8, 2022: 7, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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61Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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