CircPAPPA binds to PAPPA and promotes trophoblast proliferation in spontaneous abortion through the formation of circPAPPA-PAPPA complexes Article Swipe

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Shengtao Zhou , Liang Yu , Xiaojing Hou , Siqi Chen , Bo Liu , Shan Lü , Hong-Wei Zhou , Aihua Wu ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1016/j.gene.2025.149538

Altogether, our study shows that circPAPPA binds to PAPPA, enhancing trophoblast proliferation in vitro, and suggests that targeting the circPAPPA-PAPPA interaction might be a novel therapeutic strategy for addressing spontaneous abortion.

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Concepts

Biology Trophoblast Abortion Cell biology Molecular biology Genetics Pregnancy Fetus Placenta

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Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.gene.2025.149538
OA Status: hybrid
References: 50
Related Works: 10
OpenAlex ID: https://openalex.org/W4409999232

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OpenAlex ID: https://openalex.org/W4409999232

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DOI: https://doi.org/10.1016/j.gene.2025.149538

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Title: CircPAPPA binds to PAPPA and promotes trophoblast proliferation in spontaneous abortion through the formation of circPAPPA-PAPPA complexes

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Type: article

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Language: en

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Publication year: 2025

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Publication date: 2025-05-01

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Authors: Shengtao Zhou, Liang Yu, Xiaojing Hou, Siqi Chen, Bo Liu, Shan Lü, Hong-Wei Zhou, Aihua Wu

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Landing page: https://doi.org/10.1016/j.gene.2025.149538

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Open access: Yes

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OA status: hybrid

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OA URL: https://doi.org/10.1016/j.gene.2025.149538

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Concepts: Biology, Trophoblast, Abortion, Cell biology, Molecular biology, Genetics, Pregnancy, Fetus, Placenta

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Cited by: 0

Total citation count in OpenAlex
References (count): 50

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Related works (count): 10

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