Circular RNAs in gynecological cancer: From molecular mechanisms to clinical applications (Review) Article Swipe
Circular RNAs (circRNAs) have emerged as promising biomarkers and therapeutic targets in gynecological cancer. The present review explored developments in circRNA research in ovarian, endometrial and cervical cancer. circRNA biogenesis, functions and roles in cancer pathogenesis have been discussed, focusing on their potential as diagnostic and prognostic markers. Furthermore, circRNAs mechanisms of action, including miRNA sponging, protein scaffolding and peptide encoding were examined, highlighting specific circRNAs implicated in each cancer type and their clinical significance. The unique properties of circRNAs, such as stability and tissue-specific expression, make them ideal candidates for biomarker development. By synthesizing the currently available literature and identifying future research directions, the present review underscored circRNAs potential to improve gynecological cancer management through novel diagnostic tools, prognostic markers and targeted therapies.
Related Topics
Concepts
Molecular medicine
Oncogene
Cancer
Cell cycle
Biology
Computational biology
Medicine
Bioinformatics
Cancer research
Genetics
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3892/ol.2025.15037
- http://www.spandidos-publications.com/10.3892/ol.2025.15037/download
- OA Status
- diamond
- References
- 141
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409376463
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4409376463Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3892/ol.2025.15037Digital Object Identifier
- Title
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Circular RNAs in gynecological cancer: From molecular mechanisms to clinical applications (Review)Work title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
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2025-04-11Full publication date if available
- Authors
-
Ying Liu, Hao AiList of authors in order
- Landing page
-
https://doi.org/10.3892/ol.2025.15037Publisher landing page
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https://www.spandidos-publications.com/10.3892/ol.2025.15037/downloadDirect link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://www.spandidos-publications.com/10.3892/ol.2025.15037/downloadDirect OA link when available
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Molecular medicine, Oncogene, Cancer, Cell cycle, Biology, Computational biology, Medicine, Bioinformatics, Cancer research, GeneticsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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141Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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