Circulating FABP5 released by dying macrophages function as a DAMP to exacerbate septic inflammation Article Swipe
Rong Wu
,
Yunong Zeng
,
Jiaochan Han
,
Lei Li
,
Qingming Xiong
,
Shuyu Li
,
Shanshan Fu
,
Ping Qin
,
Ze Wang
,
Yi He
,
Zhengzheng Yan
,
Weidong Xiao
,
Zhenhua Zeng
,
Zhe‐Xiong Lian
,
Zhi-Bin Zhao
,
Wei Xiao
,
Yong Jiang
,
Shenhai Gong
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2025.116497
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2025.116497
Damage-associated molecular patterns (DAMPs) often cause an exaggerated immune response. Fatty acid-binding protein 5 (FABP5) is traditionally considered a cytosolic protein responsible for the transport of fatty acids. However, little is known about the role of FABP5 in sepsis. Herein, we found that circulating FABP5 levels were higher in patients with sepsis and were associated with adverse outcomes. The circulating FABP5 originated mainly from macrophage pyroptosis in the later stages of sepsis despite a decrease in cytoplasm-resident FABP5 expression. Functionally, circulating FABP5 penetrated the living macrophage membrane and bound to the intracellular domain of TLR4, ultimately inducing secondary inflammation through the NF-κB and MAPK pathways. Unlike circulating oxidized FABP5, cytoplasm-resident FABP5 was present in its reduced form and suppressed macrophage pyroptosis. Clearance of circulating DAMP FABP5 by preventing the passive release from dying macrophages or using a specific blocking antibody can improve survival in mice with sepsis.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.celrep.2025.116497
- OA Status
- gold
- Cited By
- 1
- References
- 55
- OpenAlex ID
- https://openalex.org/W4415773217
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Raw OpenAlex JSON
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https://openalex.org/W4415773217Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.celrep.2025.116497Digital Object Identifier
- Title
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Circulating FABP5 released by dying macrophages function as a DAMP to exacerbate septic inflammationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-10-30Full publication date if available
- Authors
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Rong Wu, Yunong Zeng, Jiaochan Han, Lei Li, Qingming Xiong, Shuyu Li, Shanshan Fu, Ping Qin, Ze Wang, Yi He, Zhengzheng Yan, Weidong Xiao, Zhenhua Zeng, Zhe‐Xiong Lian, Zhi-Bin Zhao, Wei Xiao, Yong Jiang, Shenhai GongList of authors in order
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https://doi.org/10.1016/j.celrep.2025.116497Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.celrep.2025.116497Direct OA link when available
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1Total citation count in OpenAlex
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