Circulating maternal chimeric cells have an impact on the outcome of biliary atresia Article Swipe
Ryuta Masuya
,
Toshihiro Muraji
,
Sami B. Kanaan
,
Toshio Harumatsu
,
Mitsuru Muto
,
Miki Toma
,
Toshihiro Yanai
,
Anne M. Stevens
,
J. Lee Nelson
,
Kazuhiko Nakame
,
Atsushi Nanashima
,
Satoshi Ieiri
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fped.2022.1007927
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fped.2022.1007927
Introduction We aimed to quantify the DNA of maternal chimeric (MC) cells in the peripheral blood of the BA patients and investigated the impact on the outcome. Methods Patients with progressive jaundice because of no bile flow, which necessitated liver transplantation, or who showed inadequate bile flow with or without episodes of cholangitis and progressive hepatic fibrosis and portal hypertension were classified into the poor group. Those with adequate bile flow with completely normal liver function tests beyond 2 years were classified into the good group. The qPCR were separately carried out in buffy coat samples and plasma samples, targeting the non-inherited maternal HLA alleles in the DNA samples. Results MC-DNA was present in the buffy coat (10–328 gEq per 10 6 host cells) in seven patients. There was no MC-DNA in the remaining five patients. MC-DNA (214–15,331 gEq per 10 6 host cells) was observed in the plasma of five patients. The quantity of MC-DNA in the buffy coat showed a significant difference between the two prognostic groups ( p = 0.018), whereas there was no significant difference in the quantity of MC-DNA in plasma ( p = 0.205). MC-DNA in the buffy coat was significantly associated with the outcome ( p = 0.028), whereas MC-DNA in the plasma did not influence the outcome ( p = 0.56). Conclusions Poor outcomes in BA were correlated with circulating maternal chimeric lymphocytes.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fped.2022.1007927
- https://www.frontiersin.org/articles/10.3389/fped.2022.1007927/pdf
- OA Status
- gold
- Cited By
- 3
- References
- 12
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4297906592
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4297906592Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fped.2022.1007927Digital Object Identifier
- Title
-
Circulating maternal chimeric cells have an impact on the outcome of biliary atresiaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-09-20Full publication date if available
- Authors
-
Ryuta Masuya, Toshihiro Muraji, Sami B. Kanaan, Toshio Harumatsu, Mitsuru Muto, Miki Toma, Toshihiro Yanai, Anne M. Stevens, J. Lee Nelson, Kazuhiko Nakame, Atsushi Nanashima, Satoshi IeiriList of authors in order
- Landing page
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https://doi.org/10.3389/fped.2022.1007927Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fped.2022.1007927/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fped.2022.1007927/pdfDirect OA link when available
- Concepts
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Buffy coat, Biliary atresia, Medicine, Gastroenterology, Internal medicine, DNA, Liver transplantation, Jaundice, Immunology, Transplantation, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2025: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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12Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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