Circulating MicroRNAs as Biomarkers in Diffuse Large B-cell Lymphoma: A Pilot Prospective Longitudinal Clinical Study Article Swipe
Céline Bouvy
,
Adeline Wannez
,
C Chatelain
,
Jean‐Michel Dogné
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1177/1179299x18781095
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1177/1179299x18781095
Objectives: Diffuse large B-cell lymphoma (DLBCL) is highly heterogeneous in terms of phenotype and treatment response in patients. These characteristics make the prognosis difficult to establish and hinder the use of new personalized treatments in clinical practice. In this context, there is currently a need to define new biomarkers enabling a better definition of DLBCL subtypes, prognosis evaluation, and an overview of the resistance to chemotherapeutics. The aim of this study was to evaluate the use of microRNAs found in plasma from patients with DLBCL as biomarkers of tumor evolution in these patients. Method: For this purpose, a plasma biobank was created with samples from patients with DLBCL. The evolution of the level of selected microRNAs during treatment has been studied. A total of 19 patients with DLBCL were included in this pilot mono-centered study and a total of 68 samples were analyzed. Results: The first step of this study was the selection of the microRNAs to be quantified in all the samples of the biobank and that could potentially be used as biomarkers. To this end, quantification of 377 microRNAs was performed on the plasma samples of 2 selected patients with DLBCL and 1 healthy donor with no history of cancer. Among the 377 microRNAs evaluated, 7 were selected and analyzed in the entire biobank. Conclusions: This study highlighted 5 circulating microRNAs whose plasma levels would be worth further investigating for the characterization of DLBCL evolution in patients. MiR-21 and miR-197 had a significant higher plasmatic level in patients with tumors unresponsive to treatment. With a higher plasma level in patients with complete remission, miR-19b, miR-20a, and miR-451 could enable to differentiate, at the remission review, patients with residual tumor, from patients with complete remission.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/1179299x18781095
- https://journals.sagepub.com/doi/pdf/10.1177/1179299X18781095
- OA Status
- diamond
- Cited By
- 1
- References
- 37
- Related Works
- 20
- OpenAlex ID
- https://openalex.org/W2802042278
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2802042278Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/1179299x18781095Digital Object Identifier
- Title
-
Circulating MicroRNAs as Biomarkers in Diffuse Large B-cell Lymphoma: A Pilot Prospective Longitudinal Clinical StudyWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-01-01Full publication date if available
- Authors
-
Céline Bouvy, Adeline Wannez, C Chatelain, Jean‐Michel DognéList of authors in order
- Landing page
-
https://doi.org/10.1177/1179299x18781095Publisher landing page
- PDF URL
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https://journals.sagepub.com/doi/pdf/10.1177/1179299X18781095Direct link to full text PDF
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YesWhether a free full text is available
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-
diamondOpen access status per OpenAlex
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https://journals.sagepub.com/doi/pdf/10.1177/1179299X18781095Direct OA link when available
- Concepts
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Diffuse large B-cell lymphoma, Medicine, microRNA, Lymphoma, Prospective cohort study, Biomarker, Oncology, Internal medicine, Pathology, Biology, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2022: 1Per-year citation counts (last 5 years)
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37Number of works referenced by this work
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20Other works algorithmically related by OpenAlex
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