Circulating miRNAs are Down-regulated in Asthmatic Patients; Case-control Study Article Swipe
Christian A Trejo-Jasso
,
Héctor Isaac Rocha‐González
,
Eduardo Montes-Martínez
,
Manuel Castillejos‐López
,
Arnoldo Aquíno-Gálvez
,
Dora Patricia Rosete-Olvera
,
José Sullivan López-González
,
Mario Perez-Medina
,
Martha Patricia Sierra-Vargas
,
Ángeles Carlos‐Reyes
,
M.O. Misael O. Garcia-Martin
,
Jazmín García-Machorro
,
Ángel Camarena
,
Vı́ctor Ruiz
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7150/ijms.111022
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7150/ijms.111022
Purpose: Microribonucleic acids (miRNAs) play an important role as non-invasive biomarkers and predictors of inflammatory disease activity. This study aimed to determine differences in expression profiles of miRNAs in patients with asthma compared to healthy controls (HC). Study Design and Methods: In this study, we evaluated a panel of 84 miRNAs in plasma from 3 asthmatic patients and three healthy controls (HC), and we observed decreased levels of miR-17-5p, miR-18a-5p, miR-106b-5p, miR-126-3p, miR-223-3p y miR-374a-5p which were validated in an independent group. Real-time PCR was performed to compare the expression level of each miRNA in a group of 27 asthmatic patients and 27 healthy controls. Results: Correlations between miRNAs and body mass index (BMI) and forced expiratory volume during the first second (FEV1) were also determined. Asthmatic patients had lower levels of miR-17-5p(p=0.026), miR-106-5p (p=0.022), miR-126-3p (p=0.041, and miR-223-3p (p=0.13) than healthy controls. miRNAs did not correlate with BMI and FEV₁. Conclusion: Data suggest that circulating miRNAs described in this study could be employed as biomarkers for asthma prediction.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7150/ijms.111022
- https://www.medsci.org/v22p4003.pdf
- OA Status
- gold
- References
- 2
- OpenAlex ID
- https://openalex.org/W4414204868
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4414204868Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7150/ijms.111022Digital Object Identifier
- Title
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Circulating miRNAs are Down-regulated in Asthmatic Patients; Case-control StudyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-09-08Full publication date if available
- Authors
-
Christian A Trejo-Jasso, Héctor Isaac Rocha‐González, Eduardo Montes-Martínez, Manuel Castillejos‐López, Arnoldo Aquíno-Gálvez, Dora Patricia Rosete-Olvera, José Sullivan López-González, Mario Perez-Medina, Martha Patricia Sierra-Vargas, Ángeles Carlos‐Reyes, M.O. Misael O. Garcia-Martin, Jazmín García-Machorro, Ángel Camarena, Vı́ctor RuizList of authors in order
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https://doi.org/10.7150/ijms.111022Publisher landing page
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https://www.medsci.org/v22p4003.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.medsci.org/v22p4003.pdfDirect OA link when available
- Cited by
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0Total citation count in OpenAlex
- References (count)
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2Number of works referenced by this work
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