Circulating Trimethylamine-N-Oxide Is Elevated in Liver Transplant Recipients Article Swipe
María Camila Trillos-Almanza
,
Mateo Chvatal‐Medina
,
Margery A. Connelly
,
Han Moshage
,
Stephan J. L. Bakker
,
Vincent E. de Meijer
,
Hans Blokzijl
,
Robin P. F. Dullaart
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25116031
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25116031
Liver transplant recipients (LTRs) have lower long-term survival rates compared with the general population. This underscores the necessity for developing biomarkers to assess post-transplantation mortality. Here we compared plasma trimethylamine-N-oxide (TMAO) levels with those in the general population, investigated its determinants, and interrogated its association with all-cause mortality in stable LTRs. Plasma TMAO was measured in 367 stable LTRs from the TransplantLines cohort (NCT03272841) and in 4837 participants from the population-based PREVEND cohort. TMAO levels were 35% higher in LTRs compared with PREVEND participants (4.3 vs. 3.2 µmol/L, p < 0.001). Specifically, TMAO was elevated in LTRs with metabolic dysfunction-associated steatotic liver disease, alcohol-associated liver disease, and polycystic liver disease as underlying etiology (p < 0.001 for each). Among LTRs, TMAO levels were independently associated with eGFR (std. β = −0.43, p < 0.001) and iron supplementation (std. β = 0.13, p = 0.008), and were associated with mortality (29 deaths during 8.6 years follow-up; log-rank test p = 0.017; hazard ratio of highest vs. lowest tertile 4.14, p = 0.007). In conclusion, plasma TMAO is likely elevated in stable LTRs, with impaired eGFR and iron supplementation as potential contributory factors. Our preliminary findings raise the possibility that plasma TMAO could contribute to increased mortality risk in such patients, but this need to be validated through a series of rigorous and methodical studies.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms25116031
- https://www.mdpi.com/1422-0067/25/11/6031/pdf?version=1717077080
- OA Status
- gold
- Cited By
- 4
- References
- 80
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399239606
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4399239606Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms25116031Digital Object Identifier
- Title
-
Circulating Trimethylamine-N-Oxide Is Elevated in Liver Transplant RecipientsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-30Full publication date if available
- Authors
-
María Camila Trillos-Almanza, Mateo Chvatal‐Medina, Margery A. Connelly, Han Moshage, Stephan J. L. Bakker, Vincent E. de Meijer, Hans Blokzijl, Robin P. F. DullaartList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms25116031Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/25/11/6031/pdf?version=1717077080Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/25/11/6031/pdf?version=1717077080Direct OA link when available
- Concepts
-
Medicine, Trimethylamine N-oxide, Hazard ratio, Internal medicine, Cohort, Population, Liver transplantation, Gastroenterology, Transplantation, Endocrinology, Confidence interval, Trimethylamine, Biology, Biochemistry, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4Per-year citation counts (last 5 years)
- References (count)
-
80Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4399239606 |
|---|---|
| doi | https://doi.org/10.3390/ijms25116031 |
| ids.doi | https://doi.org/10.3390/ijms25116031 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38892218 |
| ids.openalex | https://openalex.org/W4399239606 |
| fwci | 3.35614133 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000097 |
| mesh[1].descriptor_ui | D008744 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | blood |
| mesh[1].descriptor_name | Methylamines |
| mesh[2].qualifier_ui | Q000009 |
| mesh[2].descriptor_ui | D016031 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | adverse effects |
| mesh[2].descriptor_name | Liver Transplantation |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D008297 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Male |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D005260 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Female |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D008875 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Middle Aged |
| mesh[6].qualifier_ui | Q000097 |
| mesh[6].descriptor_ui | D015415 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | blood |
| mesh[6].descriptor_name | Biomarkers |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D000328 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Adult |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D000368 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Aged |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D066027 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Transplant Recipients |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D000328 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Adult |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D000368 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Aged |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D005260 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Female |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D006801 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Humans |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D008297 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Male |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D008875 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Middle Aged |
| mesh[16].qualifier_ui | Q000097 |
| mesh[16].descriptor_ui | D015415 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | blood |
| mesh[16].descriptor_name | Biomarkers |
| mesh[17].qualifier_ui | Q000009 |
| mesh[17].descriptor_ui | D016031 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | adverse effects |
| mesh[17].descriptor_name | Liver Transplantation |
| mesh[18].qualifier_ui | Q000097 |
| mesh[18].descriptor_ui | D008744 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | blood |
| mesh[18].descriptor_name | Methylamines |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D066027 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Transplant Recipients |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D000328 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Adult |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D000368 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Aged |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D005260 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Female |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D006801 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Humans |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D008297 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Male |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D008875 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Middle Aged |
| mesh[26].qualifier_ui | Q000097 |
| mesh[26].descriptor_ui | D015415 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | blood |
| mesh[26].descriptor_name | Biomarkers |
| mesh[27].qualifier_ui | Q000009 |
| mesh[27].descriptor_ui | D016031 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | adverse effects |
| mesh[27].descriptor_name | Liver Transplantation |
| mesh[28].qualifier_ui | Q000097 |
| mesh[28].descriptor_ui | D008744 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | blood |
| mesh[28].descriptor_name | Methylamines |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D066027 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Transplant Recipients |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D006801 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Humans |
| mesh[31].qualifier_ui | Q000097 |
| mesh[31].descriptor_ui | D008744 |
| mesh[31].is_major_topic | True |
| mesh[31].qualifier_name | blood |
| mesh[31].descriptor_name | Methylamines |
| mesh[32].qualifier_ui | Q000009 |
| mesh[32].descriptor_ui | D016031 |
| mesh[32].is_major_topic | True |
| mesh[32].qualifier_name | adverse effects |
| mesh[32].descriptor_name | Liver Transplantation |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D008297 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Male |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D005260 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Female |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D008875 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Middle Aged |
| mesh[36].qualifier_ui | Q000097 |
| mesh[36].descriptor_ui | D015415 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | blood |
| mesh[36].descriptor_name | Biomarkers |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D000328 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Adult |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D000368 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Aged |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D066027 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Transplant Recipients |
| type | article |
| title | Circulating Trimethylamine-N-Oxide Is Elevated in Liver Transplant Recipients |
| biblio.issue | 11 |
| biblio.volume | 25 |
| biblio.last_page | 6031 |
| biblio.first_page | 6031 |
| topics[0].id | https://openalex.org/T10337 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9995999932289124 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2721 |
| topics[0].subfield.display_name | Hepatology |
| topics[0].display_name | Liver Disease and Transplantation |
| topics[1].id | https://openalex.org/T10351 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9994000196456909 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2713 |
| topics[1].subfield.display_name | Epidemiology |
| topics[1].display_name | Liver Disease Diagnosis and Treatment |
| topics[2].id | https://openalex.org/T11207 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9993000030517578 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2734 |
| topics[2].subfield.display_name | Pathology and Forensic Medicine |
| topics[2].display_name | Alcohol Consumption and Health Effects |
| is_xpac | False |
| apc_list.value | 2300 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2490 |
| apc_paid.value | 2300 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2490 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.7154280543327332 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C2780924926 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6438560485839844 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q419802 |
| concepts[1].display_name | Trimethylamine N-oxide |
| concepts[2].id | https://openalex.org/C207103383 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6290952563285828 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q3930246 |
| concepts[2].display_name | Hazard ratio |
| concepts[3].id | https://openalex.org/C126322002 |
| concepts[3].level | 1 |
| concepts[3].score | 0.6279545426368713 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[3].display_name | Internal medicine |
| concepts[4].id | https://openalex.org/C72563966 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5879315137863159 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1303415 |
| concepts[4].display_name | Cohort |
| concepts[5].id | https://openalex.org/C2908647359 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5667747855186462 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q2625603 |
| concepts[5].display_name | Population |
| concepts[6].id | https://openalex.org/C2779609443 |
| concepts[6].level | 3 |
| concepts[6].score | 0.5307897329330444 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1368191 |
| concepts[6].display_name | Liver transplantation |
| concepts[7].id | https://openalex.org/C90924648 |
| concepts[7].level | 1 |
| concepts[7].score | 0.518863320350647 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q120569 |
| concepts[7].display_name | Gastroenterology |
| concepts[8].id | https://openalex.org/C2911091166 |
| concepts[8].level | 2 |
| concepts[8].score | 0.3878612816333771 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q106419912 |
| concepts[8].display_name | Transplantation |
| concepts[9].id | https://openalex.org/C134018914 |
| concepts[9].level | 1 |
| concepts[9].score | 0.3433114290237427 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[9].display_name | Endocrinology |
| concepts[10].id | https://openalex.org/C44249647 |
| concepts[10].level | 2 |
| concepts[10].score | 0.16993364691734314 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q208498 |
| concepts[10].display_name | Confidence interval |
| concepts[11].id | https://openalex.org/C2776149385 |
| concepts[11].level | 2 |
| concepts[11].score | 0.13727626204490662 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q423953 |
| concepts[11].display_name | Trimethylamine |
| concepts[12].id | https://openalex.org/C86803240 |
| concepts[12].level | 0 |
| concepts[12].score | 0.13715609908103943 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[12].display_name | Biology |
| concepts[13].id | https://openalex.org/C55493867 |
| concepts[13].level | 1 |
| concepts[13].score | 0.0627724826335907 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[13].display_name | Biochemistry |
| concepts[14].id | https://openalex.org/C99454951 |
| concepts[14].level | 1 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q932068 |
| concepts[14].display_name | Environmental health |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.7154280543327332 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/trimethylamine-n-oxide |
| keywords[1].score | 0.6438560485839844 |
| keywords[1].display_name | Trimethylamine N-oxide |
| keywords[2].id | https://openalex.org/keywords/hazard-ratio |
| keywords[2].score | 0.6290952563285828 |
| keywords[2].display_name | Hazard ratio |
| keywords[3].id | https://openalex.org/keywords/internal-medicine |
| keywords[3].score | 0.6279545426368713 |
| keywords[3].display_name | Internal medicine |
| keywords[4].id | https://openalex.org/keywords/cohort |
| keywords[4].score | 0.5879315137863159 |
| keywords[4].display_name | Cohort |
| keywords[5].id | https://openalex.org/keywords/population |
| keywords[5].score | 0.5667747855186462 |
| keywords[5].display_name | Population |
| keywords[6].id | https://openalex.org/keywords/liver-transplantation |
| keywords[6].score | 0.5307897329330444 |
| keywords[6].display_name | Liver transplantation |
| keywords[7].id | https://openalex.org/keywords/gastroenterology |
| keywords[7].score | 0.518863320350647 |
| keywords[7].display_name | Gastroenterology |
| keywords[8].id | https://openalex.org/keywords/transplantation |
| keywords[8].score | 0.3878612816333771 |
| keywords[8].display_name | Transplantation |
| keywords[9].id | https://openalex.org/keywords/endocrinology |
| keywords[9].score | 0.3433114290237427 |
| keywords[9].display_name | Endocrinology |
| keywords[10].id | https://openalex.org/keywords/confidence-interval |
| keywords[10].score | 0.16993364691734314 |
| keywords[10].display_name | Confidence interval |
| keywords[11].id | https://openalex.org/keywords/trimethylamine |
| keywords[11].score | 0.13727626204490662 |
| keywords[11].display_name | Trimethylamine |
| keywords[12].id | https://openalex.org/keywords/biology |
| keywords[12].score | 0.13715609908103943 |
| keywords[12].display_name | Biology |
| keywords[13].id | https://openalex.org/keywords/biochemistry |
| keywords[13].score | 0.0627724826335907 |
| keywords[13].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.3390/ijms25116031 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S10623703 |
| locations[0].source.issn | 1422-0067, 1661-6596 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1422-0067 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | International Journal of Molecular Sciences |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1422-0067/25/11/6031/pdf?version=1717077080 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | International Journal of Molecular Sciences |
| locations[0].landing_page_url | https://doi.org/10.3390/ijms25116031 |
| locations[1].id | pmid:38892218 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | International journal of molecular sciences |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38892218 |
| locations[2].id | pmh:oai:mdpi.com:/1422-0067/25/11/6031/ |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400947 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | True |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | MDPI (MDPI AG) |
| locations[2].source.host_organization | https://openalex.org/I4210097602 |
| locations[2].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[2].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | International Journal of Molecular Sciences |
| locations[2].landing_page_url | https://dx.doi.org/10.3390/ijms25116031 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:11172608 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Int J Mol Sci |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11172608 |
| locations[4].id | pmh:oai:pure.rug.nl:openaire/8835fa3b-34af-40ed-8a69-56b89edc208c |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306400420 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | University of Groningen research database (University of Groningen / Centre for Information Technology) |
| locations[4].source.host_organization | https://openalex.org/I169381384 |
| locations[4].source.host_organization_name | University of Groningen |
| locations[4].source.host_organization_lineage | https://openalex.org/I169381384 |
| locations[4].license | cc-by |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | https://openalex.org/licenses/cc-by |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | TransplantLines Investigators, Trillos-Almanza, M C, Chvatal-Medina, M, Connelly, M A, Moshage, H, Bakker, S J L, de Meijer, V E, Blokzijl, H & Dullaart, R P F 2024, 'Circulating Trimethylamine-N-Oxide Is Elevated in Liver Transplant Recipients', International Journal of Molecular Sciences, vol. 25, no. 11, 6031. https://doi.org/10.3390/ijms25116031 |
| locations[4].landing_page_url | https://research.rug.nl/en/publications/8835fa3b-34af-40ed-8a69-56b89edc208c |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5071840002 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-9714-5809 |
| authorships[0].author.display_name | María Camila Trillos-Almanza |
| authorships[0].countries | NL |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I1334415907, https://openalex.org/I169381384 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
| authorships[0].institutions[0].id | https://openalex.org/I1334415907 |
| authorships[0].institutions[0].ror | https://ror.org/03cv38k47 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I1334415907 |
| authorships[0].institutions[0].country_code | NL |
| authorships[0].institutions[0].display_name | University Medical Center Groningen |
| authorships[0].institutions[1].id | https://openalex.org/I169381384 |
| authorships[0].institutions[1].ror | https://ror.org/012p63287 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I169381384 |
| authorships[0].institutions[1].country_code | NL |
| authorships[0].institutions[1].display_name | University of Groningen |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Maria Camila Trillos-Almanza |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
| authorships[1].author.id | https://openalex.org/A5024047415 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-4310-5657 |
| authorships[1].author.display_name | Mateo Chvatal‐Medina |
| authorships[1].countries | NL |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1334415907, https://openalex.org/I169381384 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
| authorships[1].institutions[0].id | https://openalex.org/I1334415907 |
| authorships[1].institutions[0].ror | https://ror.org/03cv38k47 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I1334415907 |
| authorships[1].institutions[0].country_code | NL |
| authorships[1].institutions[0].display_name | University Medical Center Groningen |
| authorships[1].institutions[1].id | https://openalex.org/I169381384 |
| authorships[1].institutions[1].ror | https://ror.org/012p63287 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I169381384 |
| authorships[1].institutions[1].country_code | NL |
| authorships[1].institutions[1].display_name | University of Groningen |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Mateo Chvatal-Medina |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
| authorships[2].author.id | https://openalex.org/A5005538765 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-3917-592X |
| authorships[2].author.display_name | Margery A. Connelly |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2801558778 |
| authorships[2].affiliations[0].raw_affiliation_string | Labcorp, 100 Perimeter Park, Morrisville, NC 27560, USA |
| authorships[2].institutions[0].id | https://openalex.org/I2801558778 |
| authorships[2].institutions[0].ror | https://ror.org/03zsdhz84 |
| authorships[2].institutions[0].type | company |
| authorships[2].institutions[0].lineage | https://openalex.org/I2801558778 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | LabCorp (United States) |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Margery A. Connelly |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Labcorp, 100 Perimeter Park, Morrisville, NC 27560, USA |
| authorships[3].author.id | https://openalex.org/A5043968888 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-4764-0246 |
| authorships[3].author.display_name | Han Moshage |
| authorships[3].countries | NL |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1334415907, https://openalex.org/I169381384 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
| authorships[3].institutions[0].id | https://openalex.org/I1334415907 |
| authorships[3].institutions[0].ror | https://ror.org/03cv38k47 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I1334415907 |
| authorships[3].institutions[0].country_code | NL |
| authorships[3].institutions[0].display_name | University Medical Center Groningen |
| authorships[3].institutions[1].id | https://openalex.org/I169381384 |
| authorships[3].institutions[1].ror | https://ror.org/012p63287 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I169381384 |
| authorships[3].institutions[1].country_code | NL |
| authorships[3].institutions[1].display_name | University of Groningen |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Han Moshage |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
| authorships[4].author.id | https://openalex.org/A5038949732 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-3356-6791 |
| authorships[4].author.display_name | Stephan J. L. Bakker |
| authorships[4].countries | NL |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1334415907, https://openalex.org/I169381384 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
| authorships[4].institutions[0].id | https://openalex.org/I1334415907 |
| authorships[4].institutions[0].ror | https://ror.org/03cv38k47 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I1334415907 |
| authorships[4].institutions[0].country_code | NL |
| authorships[4].institutions[0].display_name | University Medical Center Groningen |
| authorships[4].institutions[1].id | https://openalex.org/I169381384 |
| authorships[4].institutions[1].ror | https://ror.org/012p63287 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I169381384 |
| authorships[4].institutions[1].country_code | NL |
| authorships[4].institutions[1].display_name | University of Groningen |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Stephan J. L. Bakker |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
| authorships[5].author.id | https://openalex.org/A5046096257 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-7900-5917 |
| authorships[5].author.display_name | Vincent E. de Meijer |
| authorships[5].countries | NL |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I1334415907, https://openalex.org/I169381384 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Surgery, Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
| authorships[5].institutions[0].id | https://openalex.org/I1334415907 |
| authorships[5].institutions[0].ror | https://ror.org/03cv38k47 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I1334415907 |
| authorships[5].institutions[0].country_code | NL |
| authorships[5].institutions[0].display_name | University Medical Center Groningen |
| authorships[5].institutions[1].id | https://openalex.org/I169381384 |
| authorships[5].institutions[1].ror | https://ror.org/012p63287 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I169381384 |
| authorships[5].institutions[1].country_code | NL |
| authorships[5].institutions[1].display_name | University of Groningen |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Vincent E. de Meijer |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Surgery, Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
| authorships[6].author.id | https://openalex.org/A5006389083 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-4240-7506 |
| authorships[6].author.display_name | Hans Blokzijl |
| authorships[6].countries | NL |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I1334415907, https://openalex.org/I169381384 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
| authorships[6].institutions[0].id | https://openalex.org/I1334415907 |
| authorships[6].institutions[0].ror | https://ror.org/03cv38k47 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I1334415907 |
| authorships[6].institutions[0].country_code | NL |
| authorships[6].institutions[0].display_name | University Medical Center Groningen |
| authorships[6].institutions[1].id | https://openalex.org/I169381384 |
| authorships[6].institutions[1].ror | https://ror.org/012p63287 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I169381384 |
| authorships[6].institutions[1].country_code | NL |
| authorships[6].institutions[1].display_name | University of Groningen |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Hans Blokzijl |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
| authorships[7].author.id | https://openalex.org/A5041851398 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-3844-5254 |
| authorships[7].author.display_name | Robin P. F. Dullaart |
| authorships[7].countries | NL |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I1334415907, https://openalex.org/I169381384 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Internal Medicine, Division of Endocrinology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
| authorships[7].institutions[0].id | https://openalex.org/I1334415907 |
| authorships[7].institutions[0].ror | https://ror.org/03cv38k47 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I1334415907 |
| authorships[7].institutions[0].country_code | NL |
| authorships[7].institutions[0].display_name | University Medical Center Groningen |
| authorships[7].institutions[1].id | https://openalex.org/I169381384 |
| authorships[7].institutions[1].ror | https://ror.org/012p63287 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I169381384 |
| authorships[7].institutions[1].country_code | NL |
| authorships[7].institutions[1].display_name | University of Groningen |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Robin P. F. Dullaart |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Internal Medicine, Division of Endocrinology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1422-0067/25/11/6031/pdf?version=1717077080 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Circulating Trimethylamine-N-Oxide Is Elevated in Liver Transplant Recipients |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10337 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9995999932289124 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2721 |
| primary_topic.subfield.display_name | Hepatology |
| primary_topic.display_name | Liver Disease and Transplantation |
| related_works | https://openalex.org/W2966808768, https://openalex.org/W3196893239, https://openalex.org/W2781109657, https://openalex.org/W2884965035, https://openalex.org/W4392355539, https://openalex.org/W3011950001, https://openalex.org/W3160040649, https://openalex.org/W3135420509, https://openalex.org/W2257321757, https://openalex.org/W2092741754 |
| cited_by_count | 4 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 4 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3390/ijms25116031 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S10623703 |
| best_oa_location.source.issn | 1422-0067, 1661-6596 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1422-0067 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | International Journal of Molecular Sciences |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1422-0067/25/11/6031/pdf?version=1717077080 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | International Journal of Molecular Sciences |
| best_oa_location.landing_page_url | https://doi.org/10.3390/ijms25116031 |
| primary_location.id | doi:10.3390/ijms25116031 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S10623703 |
| primary_location.source.issn | 1422-0067, 1661-6596 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1422-0067 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | International Journal of Molecular Sciences |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1422-0067/25/11/6031/pdf?version=1717077080 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | International Journal of Molecular Sciences |
| primary_location.landing_page_url | https://doi.org/10.3390/ijms25116031 |
| publication_date | 2024-05-30 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W4388688079, https://openalex.org/W4322489648, https://openalex.org/W3026780737, https://openalex.org/W4385294826, https://openalex.org/W4280565344, https://openalex.org/W4386753691, https://openalex.org/W3087520953, https://openalex.org/W2172627233, https://openalex.org/W2980141417, https://openalex.org/W4362660949, https://openalex.org/W2893654943, https://openalex.org/W3108294227, https://openalex.org/W2984669963, https://openalex.org/W2765915044, https://openalex.org/W3216236631, https://openalex.org/W2998218626, https://openalex.org/W3090724377, https://openalex.org/W2551397368, https://openalex.org/W2904124435, https://openalex.org/W3139395802, https://openalex.org/W3185521202, https://openalex.org/W2162078360, https://openalex.org/W3125483240, https://openalex.org/W3165113341, https://openalex.org/W3160171607, https://openalex.org/W4206391509, https://openalex.org/W2397682060, https://openalex.org/W4318053848, https://openalex.org/W3196283962, https://openalex.org/W4280504858, https://openalex.org/W2503203035, https://openalex.org/W2953326458, https://openalex.org/W3171288373, https://openalex.org/W2295039438, https://openalex.org/W2892844483, https://openalex.org/W2791083955, https://openalex.org/W3039902900, https://openalex.org/W2970446816, https://openalex.org/W2582320162, https://openalex.org/W3199420649, https://openalex.org/W1890771959, https://openalex.org/W3097073018, https://openalex.org/W2340365027, https://openalex.org/W6760574531, https://openalex.org/W1971298315, https://openalex.org/W2051678458, https://openalex.org/W1558182028, https://openalex.org/W3130797922, https://openalex.org/W2115944543, https://openalex.org/W4286111143, https://openalex.org/W2917538340, https://openalex.org/W4318922867, https://openalex.org/W3153867501, https://openalex.org/W4283825982, https://openalex.org/W2946264652, https://openalex.org/W4205968612, https://openalex.org/W6842566335, https://openalex.org/W2980944208, https://openalex.org/W4297238111, https://openalex.org/W3154550454, https://openalex.org/W2888970411, https://openalex.org/W3128032316, https://openalex.org/W2916252363, https://openalex.org/W2919947473, https://openalex.org/W1991855600, https://openalex.org/W2150350691, https://openalex.org/W4292229870, https://openalex.org/W2908082263, https://openalex.org/W4292528167, https://openalex.org/W2139930612, https://openalex.org/W2986732587, https://openalex.org/W2898838268, https://openalex.org/W2118625269, https://openalex.org/W2023797086, https://openalex.org/W3083844534, https://openalex.org/W1570622790, https://openalex.org/W2599076725, https://openalex.org/W4292582594, https://openalex.org/W4206993389, https://openalex.org/W2920820971 |
| referenced_works_count | 80 |
| abstract_inverted_index.= | 129, 139, 142, 158, 169 |
| abstract_inverted_index.a | 216 |
| abstract_inverted_index.p | 88, 131, 141, 157, 168 |
| abstract_inverted_index.(p | 113 |
| abstract_inverted_index.In | 171 |
| abstract_inverted_index.as | 110, 187 |
| abstract_inverted_index.be | 213 |
| abstract_inverted_index.in | 34, 48, 55, 65, 78, 95, 178, 206 |
| abstract_inverted_index.is | 175 |
| abstract_inverted_index.of | 162, 218 |
| abstract_inverted_index.to | 21, 202, 212 |
| abstract_inverted_index.we | 26 |
| abstract_inverted_index.β | 128, 138 |
| abstract_inverted_index.(29 | 149 |
| abstract_inverted_index.3.2 | 86 |
| abstract_inverted_index.35% | 76 |
| abstract_inverted_index.367 | 56 |
| abstract_inverted_index.8.6 | 152 |
| abstract_inverted_index.Our | 191 |
| abstract_inverted_index.and | 41, 64, 106, 134, 144, 184, 220 |
| abstract_inverted_index.but | 209 |
| abstract_inverted_index.for | 18, 116 |
| abstract_inverted_index.its | 39, 43 |
| abstract_inverted_index.the | 11, 16, 35, 60, 69, 195 |
| abstract_inverted_index.vs. | 85, 164 |
| abstract_inverted_index.was | 53, 93 |
| abstract_inverted_index.< | 89, 114, 132 |
| abstract_inverted_index.(4.3 | 84 |
| abstract_inverted_index.4837 | 66 |
| abstract_inverted_index.Here | 25 |
| abstract_inverted_index.LTRs | 58, 79, 96 |
| abstract_inverted_index.TMAO | 52, 73, 92, 120, 174, 199 |
| abstract_inverted_index.This | 14 |
| abstract_inverted_index.eGFR | 126, 183 |
| abstract_inverted_index.from | 59, 68 |
| abstract_inverted_index.have | 4 |
| abstract_inverted_index.iron | 135, 185 |
| abstract_inverted_index.need | 211 |
| abstract_inverted_index.risk | 205 |
| abstract_inverted_index.such | 207 |
| abstract_inverted_index.test | 156 |
| abstract_inverted_index.that | 197 |
| abstract_inverted_index.this | 210 |
| abstract_inverted_index.were | 75, 122, 145 |
| abstract_inverted_index.with | 10, 32, 45, 81, 97, 125, 147, 181 |
| abstract_inverted_index.(std. | 127, 137 |
| abstract_inverted_index.0.001 | 115 |
| abstract_inverted_index.0.13, | 140 |
| abstract_inverted_index.4.14, | 167 |
| abstract_inverted_index.Among | 118 |
| abstract_inverted_index.LTRs, | 119, 180 |
| abstract_inverted_index.LTRs. | 50 |
| abstract_inverted_index.Liver | 0 |
| abstract_inverted_index.could | 200 |
| abstract_inverted_index.liver | 101, 104, 108 |
| abstract_inverted_index.lower | 5 |
| abstract_inverted_index.raise | 194 |
| abstract_inverted_index.rates | 8 |
| abstract_inverted_index.ratio | 161 |
| abstract_inverted_index.those | 33 |
| abstract_inverted_index.years | 153 |
| abstract_inverted_index.(LTRs) | 3 |
| abstract_inverted_index.(TMAO) | 30 |
| abstract_inverted_index.0.001) | 133 |
| abstract_inverted_index.0.017; | 159 |
| abstract_inverted_index.Plasma | 51 |
| abstract_inverted_index.assess | 22 |
| abstract_inverted_index.cohort | 62 |
| abstract_inverted_index.deaths | 150 |
| abstract_inverted_index.during | 151 |
| abstract_inverted_index.each). | 117 |
| abstract_inverted_index.hazard | 160 |
| abstract_inverted_index.higher | 77 |
| abstract_inverted_index.levels | 31, 74, 121 |
| abstract_inverted_index.likely | 176 |
| abstract_inverted_index.lowest | 165 |
| abstract_inverted_index.plasma | 28, 173, 198 |
| abstract_inverted_index.series | 217 |
| abstract_inverted_index.stable | 49, 57, 179 |
| abstract_inverted_index.0.001). | 90 |
| abstract_inverted_index.0.007). | 170 |
| abstract_inverted_index.0.008), | 143 |
| abstract_inverted_index.PREVEND | 71, 82 |
| abstract_inverted_index.cohort. | 72 |
| abstract_inverted_index.disease | 109 |
| abstract_inverted_index.general | 12, 36 |
| abstract_inverted_index.highest | 163 |
| abstract_inverted_index.tertile | 166 |
| abstract_inverted_index.through | 215 |
| abstract_inverted_index.compared | 9, 27, 80 |
| abstract_inverted_index.disease, | 102, 105 |
| abstract_inverted_index.elevated | 94, 177 |
| abstract_inverted_index.etiology | 112 |
| abstract_inverted_index.factors. | 190 |
| abstract_inverted_index.findings | 193 |
| abstract_inverted_index.impaired | 182 |
| abstract_inverted_index.log-rank | 155 |
| abstract_inverted_index.measured | 54 |
| abstract_inverted_index.rigorous | 219 |
| abstract_inverted_index.studies. | 222 |
| abstract_inverted_index.survival | 7 |
| abstract_inverted_index.µmol/L, | 87 |
| abstract_inverted_index.−0.43, | 130 |
| abstract_inverted_index.all-cause | 46 |
| abstract_inverted_index.increased | 203 |
| abstract_inverted_index.long-term | 6 |
| abstract_inverted_index.metabolic | 98 |
| abstract_inverted_index.mortality | 47, 148, 204 |
| abstract_inverted_index.necessity | 17 |
| abstract_inverted_index.patients, | 208 |
| abstract_inverted_index.potential | 188 |
| abstract_inverted_index.steatotic | 100 |
| abstract_inverted_index.validated | 214 |
| abstract_inverted_index.associated | 124, 146 |
| abstract_inverted_index.biomarkers | 20 |
| abstract_inverted_index.contribute | 201 |
| abstract_inverted_index.developing | 19 |
| abstract_inverted_index.follow-up; | 154 |
| abstract_inverted_index.methodical | 221 |
| abstract_inverted_index.mortality. | 24 |
| abstract_inverted_index.polycystic | 107 |
| abstract_inverted_index.recipients | 2 |
| abstract_inverted_index.transplant | 1 |
| abstract_inverted_index.underlying | 111 |
| abstract_inverted_index.association | 44 |
| abstract_inverted_index.conclusion, | 172 |
| abstract_inverted_index.population, | 37 |
| abstract_inverted_index.population. | 13 |
| abstract_inverted_index.possibility | 196 |
| abstract_inverted_index.preliminary | 192 |
| abstract_inverted_index.underscores | 15 |
| abstract_inverted_index.contributory | 189 |
| abstract_inverted_index.interrogated | 42 |
| abstract_inverted_index.investigated | 38 |
| abstract_inverted_index.participants | 67, 83 |
| abstract_inverted_index.(NCT03272841) | 63 |
| abstract_inverted_index.Specifically, | 91 |
| abstract_inverted_index.determinants, | 40 |
| abstract_inverted_index.independently | 123 |
| abstract_inverted_index.TransplantLines | 61 |
| abstract_inverted_index.supplementation | 136, 186 |
| abstract_inverted_index.population-based | 70 |
| abstract_inverted_index.alcohol-associated | 103 |
| abstract_inverted_index.post-transplantation | 23 |
| abstract_inverted_index.dysfunction-associated | 99 |
| abstract_inverted_index.trimethylamine-N-oxide | 29 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5071840002 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I1334415907, https://openalex.org/I169381384 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8799999952316284 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.85925299 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |